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M8 B hydrochloride

Catalog #: 5324 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5324/10
5324/50
M8 B hydrochloride | CAS No. 883976-12-3 | TRPM Blockers
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Description: Potent and selective TRPM8 channel blocker

Chemical Name: N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride

Purity: ≥99%

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Biological Activity

M8 B hydrochloride is a potent and selective TRPM8 channel blocker. Blocks cold- and icilin-induced TRPM8 activation in vitro (IC50 values are 7.8 and 26.9 nM respectively). Exhibits no effect at other TRP channels (IC50 > 20 μM). Reduces body temperature in vivo.

Technical Data

M.Wt:
432.96
Formula:
C22H24N2O3S.HCl
Solubility:
Soluble to 10 mM in water with sonication and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
883976-12-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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