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M871

Catalog #: 2698
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2698/1
M871
1 Image
Description: Selective GAL2 antagonist
Alternative Names: Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide

Purity: ≥95%

Product Details
Citations (6)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

M871 is a selective galanin GAL2 receptor antagonist (Ki values are 13.1 and 420 nM for GAL2 and GAL1 receptors respectively). Blocks the pro-nociceptive effect of GAL2 receptor agonists.

Technical Data

M.Wt:
2287.64
Formula:
C108H163N27O28
Sequence:
WTLNSAGYLLGPEHPPPALALA

(Modification: Ala-22 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
908844-75-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Activation of peripheral galanin receptors: differential effects on nociception.
    Jimenez-Andrade et al.
    Pharmacol.Biochem.Behav., 2006;85:273
  2. M871 - a novel peptide antagonist selectively recognizing the galanin receptor type 2.
    Sollenburg et al.
    Int.J.Pept.Res.Ther., 2006;12:115

Product Datasheets

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Citations for M871

The citations listed below are publications that use Tocris products. Selected citations for M871 include:

6 Citations: Showing 1 - 6

  1. Dorsal hippocampal galanin modulates anxiety-like behaviours in rats.
    Authors: Funck
    Brain Res  2018;1688:75
  2. Central galanin receptor 2 mediates galanin action to promote systemic glucose metabolism of type 2 diabetic rats.
    Authors: Fang
    Biochem Pharmacol  2018;156:241
  3. Involvement of galanin and galanin receptor 2 in nociceptive modulation in anterior cingulatecortex of normal rats and rats with mononeuropathy
    Authors: Zhang
    Sci Rep  2017;7:45930
  4. Galanin modulates the neural niche to favour perineural invasion in head and neck cancer.
    Authors: Scanlon Et al.
    Int J Neuropsychopharmacol  2015;6:6885
  5. A role for galanin N-terminal fragment (1-15) in anxiety- and depression-related behaviors in rats.
    Authors: Millón Et al.
    Immun Inflamm Dis  2015;18
  6. A role for galanin N-terminal fragment (1-15) in anxiety- and depression-related behaviors in rats.
    Authors: Millòn Et al.
    Int.J.Neuropsychopharmacol.  2014;18

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