MC 1742
Chemical Name: 5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide
Purity: ≥98%
Biological Activity
MC 1742 is a potent class I and IIb HDAC inhibitor (IC50 values are 7, 20, 40, 100, 110 and 610 nM for HDAC6, HDAC3, HDAC10, HDAC1, HDAC2 and HDAC8, respectively). Suppresses proliferation and induces apoptosis of sarcoma cancer stem cells (CSCs) at concentrations >500 nM. Also induces osteogenesis in sarcoma CSCs at concentrations of 25 - 500 nM.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells.
Di Pompo et al.
J.Med.Chem., 2015;58:4073 -
Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities.
Mai et al.
Bioorg.Med.Chem.Lett., 2008;18:2530 -
Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors.
Mai et al.
J.Med.Chem., 2006;49:6046
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