Metyrapone
Chemical Name: 2-Methyl-1,2-di-3-pyridinyl-1-propanone
Purity: ≥98%
Biological Activity
Metyrapone is a cytochrome P450 inhibitor. Blocks glucocorticoid synthesis via inhibition of steroid 11-β hydroxylase (CYP11B1) activity (IC50 = 7.83 μM). Also inhibits CYP3A4 and cytochrome P450-mediated ω/ω-1 hydroxylase activity.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Cytochrome P450-mediated prostaglandin omega/omega-1 hydroxylase activities in porcine ciliary body epithelial cells.
Asakura and Shichi
Exp.Eye Res., 1992;55:377 -
Structural and dynamic basis of broad substrate specificity, catalytic mechanism and inhibition of cytochrome P450 3A4.
Park et al.
J.Am.Chem.Soc., 2005;127:13634 -
Structure-activity relationship study of the inhibition of adrenal cortical 11β-hydroxylase by new metyr. analogues.
Hays et al.
J.Med.Chem., 1984;27:15
Product Datasheets
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Citations for Metyrapone
The citations listed below are publications that use Tocris products. Selected citations for Metyrapone include:
3 Citations: Showing 1 - 3
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Lymphoid organs of neonatal and adult mice preferentially produce active glucocorticoids from metabolites, not precursors.
Authors: Taves Et al.
Brain Behav.Immun. 2016;57:271
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Enduring good memories of infant trauma: rescue of adult neurobehavioral deficits via amygdala serotonin and corticosterone interaction.
Authors: Rincón-Cortés Et al.
Brain Res 2015;112:881
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Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents.
Authors: Liu Et al.
Mol Brain 2014;7:32
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