Miglustat hydrochloride
Chemical Name: (2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)-3,4,5-piperidinetriol hydrochloride
Biological Activity
Miglustat hydrochloride is an orally active α-glucosidase I and II and ceramide-specific glycosyltransferase inhibitor. Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of ER α-glucosidases I and II. Also has broad spectrum antiviral activity.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
- Deuterated analog also available
Background References
-
N-Butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis.
Platt et al.
J.Biol.Chem., 1994;269:8362 -
Targeting glycosylation as a therapeutic approach.
Dwek et al.
Nat.Rev.Drug Disc., 2002;1:65 -
Parallel improvements of sodium and chloride transport defects by migl. (n-butyldeoxynojyrimicin) in cystic fibrosis epithelial cells.
Noel et al.
J.Pharmacol.Exp.Ther., 2008;325:1016
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