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MK6-83

Catalog #: 5547
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5547/10
5547/50
MK6-83 | CAS No. 1062271-24-2 | TRPML Channel Activators
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Description: TRPML channel activator

Chemical Name: 5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

MK6-83 is a TRPML channel activator (EC50 = 110 nM). Also activates F408Δ and F465L TRPML mutants (EC50 values are 0.1 and 1.23 μM respectively). Restores endolysosomal trafficking and zinc homeostasis in lysosomes of mucolipidosis type IV (MLIV) mutant fibroblasts.

Technical Data

M.Wt:
336.47
Formula:
C16H20N2O2S2
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1062271-24-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for MK6-83

The citations listed below are publications that use Tocris products. Selected citations for MK6-83 include:

2 Citations: Showing 1 - 2

  1. RagD auto-activating mutations impair MiT/TFE activity in kidney tubulopathy and cardiomyopathy syndrome.
    Authors: Giancarlo Et al.
    Nat Commun  2023;14:2775
  2. Robust lysosomal calcium signaling through channel TRPML1 is impaired by lysosomal lipid accumulation.
    Authors: Steven J Et al.
    FASEB J  2018;32:782-794

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