Home / Additional Lysine Methyltransferase Compounds / MM 102

MM 102

Catalog #: 5307
2 Citations Datasheet / COA / SDS
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5307/10
MM 102 | CAS No. 1883545-52-5 | Additional Lysine Methyltransferase Compounds
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Description: Potent WDR5/MLL interaction inhibitor

Chemical Name: 1-[[(2S)-5-[(Aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]-cyclopentanecarboxamide trifluoroacetate

Purity: ≥95%

Product Details
Citations (2)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

MM 102 is a potent WDR5/MLL interaction inhibitor (IC50 = 2.4 nM). Inhibits MLL1 methyltransferase activity and MLL-1-induced HoxA9 and Meis-1 gene expression in leukemia cells expressing the MLL1-AF9 fusion gene. Also inhibits cell growth and induces apoptosis in leukemia cells harbouring MLL1 fusion proteins.

Technical Data

M.Wt:
783.83
Formula:
C35H49F2N7O4.CF3CO2H
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
1883545-52-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction.
    Karatas et al.
    J.Am.Chem.Soc., 2013;135:669

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Citations for MM 102

The citations listed below are publications that use Tocris products. Selected citations for MM 102 include:

2 Citations: Showing 1 - 2

  1. Inhibition of the H3K4 methyltransferase MLL1/WDR5 complex attenuates renal senescence in ischemia reperfusion mice by reduction of p16INK4a.
    Authors: Ayumu Et al.
    Kidney Int  2019;96:1162-1175
  2. Epigenetic stabilization of DC and DC precursor classical activation by TNFα contributes to protective T cell polarization.
    Authors: Ilona Et al.
    Sci Adv  2019;5:eaaw9051

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