Mouse DCAR/CLEC4B Alexa Fluor® 350-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: DCAR/CLEC4B

Dendritic Cell immuno-Activating Receptor alpha isoform (DCAR) is a type II membrane protein belonging to the C-type lectin domain family and is designated CLEC4B. Two isoforms of DCAR exist, a 209 amino acid (aa) residue alpha isoform and a 176 aa form with a 33 aa deletion at the membrane proximal region of the extracellular domain. The DCAR extracellular domain contains a carbohydrate-recognition domain (CRD) that shares 91% amino acid sequence identity with the CRD of DCIR/CLEC4A. The DCAR intracellular domain is very short and lacks the ITIM motif found in DCIR. DCAR and DCIR are considered paired immunoregulatory receptors where DCAR activates through the ITAM of its associated adaptor molecule FcR gamma.

Product Datasheets

Product Specific Notices

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Related Research Areas

• C-type Lectin Family
• C-type Lectin Receptors
• Dendritic Cell ITIM/ITAM Immunoreceptors
• Dendritic Cell Pathogen Recognition/Uptake
• ITIM/ITAM Immunoreceptors and Related Molecules