Mouse F4/80 PE-conjugated Antibody Summary
Gln28-Gly931
Accession # Q61549
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of F4/80/EMR1 in RAW 264.7 Mouse Cell Line by Flow Cytometry. RAW 264.7 mouse monocyte/macrophage cell line was stained with Rat Anti-Mouse F4/80/EMR1 PE-conjugated Monoclonal Antibody (Catalog # FAB5580P, filled histogram) or isotype control antibody (Catalog # IC006P, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
Background: F4/80
F4/80, also known as EMR1 in humans, is a 160 kDa glycosylated protein that belongs to the EGF-TM7 family of adhesion molecules. It is expressed on splenic red pulp and bone marrow, macrophages, microglia, Langerhans cells, monocytes, eosinophils, and CD116+ dendritic cells in mouse, but is restricted to eosinophils in human. F4/80 plays a role in the development of peripheral tolerance, being necessary for the development of CD8+ T regs. It also serves as a marker for IL-1 beta + proinflammatory macrophages.
Product Datasheets
Citations for Mouse F4/80 PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 6
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Gamma-tocotrienol inhibits lipopolysaccharide-induced interlukin-6 and granulocyte-colony stimulating factor by suppressing C/EBP-beta and NF-kappa B in macrophages
Authors: Yun Wang, Qing Jiang
The Journal of Nutritional Biochemistry
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Tumor-Released Products Promote Bone Marrow-Derived Macrophage Survival and Proliferation
Authors: JM Motta, VM Rumjanek, A Mantovani, M Locati
Biomedicines, 2021-10-04;9(10):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Functional loss of inactive rhomboid-like protein�2 mitigates obesity by suppressing pro-inflammatory macrophage activation-triggered adipose inflammation
Authors: M Xu, C Ge, Y Qin, D Lou, Q Li, J Feng, Y Wu, L Hu, B Wang, J Tan
Mol Metab, 2020-01-22;34(0):112-123.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC -
Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK-NF-?B signaling mediated inflammation
Authors: J Ben, B Jiang, D Wang, Q Liu, Y Zhang, Y Qi, X Tong, L Chen, X Liu, Y Zhang, X Zhu, X Li, H Zhang, H Bai, Q Yang, J Ma, EAC Wiemer, Y Xu, Q Chen
Nat Commun, 2019-04-17;10(1):1801.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
IL-12 promotes myeloid-derived suppressor cell recruitment and bacterial persistence during Staphylococcus aureus orthopedic implant infection.
Authors: Heim C, Vidlak D, Scherr T, Hartman C, Garvin K, Kielian T
J Immunol, 2015-03-11;194(8):3861-72.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Galectin-3 negatively regulates the frequency and function of CD4(+) CD25(+) Foxp3(+) regulatory T cells and influences the course of Leishmania major infection.
Authors: Fermino M, Dias F, Lopes C, Souza M, Cruz A, Liu F, Chammas R, Roque-Barreira M, Rabinovich G, Bernardes E
Eur J Immunol, 2013-05-17;43(7):1806-17.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
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