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Mouse IL-17/IL-17A Antibody

Catalog #: MAB421
90 Citations 2 Reviews Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB421-SP
MAB421-100
MAB421-500
Detection of Recombinant Mouse IL‑17/IL‑17A by Western Blot.
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Citations (90)
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Reviews (2)
Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Mouse IL-17/IL-17A Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse IL-17 in direct ELISAs and Western blots. In direct ELISAs, 100% reactivity with recombinant rat IL-17A and approximately 40% reactivity with recombinant mouse
(rm) IL-17A/IL-17F heterodimer is observed. No cross-reactivity with recombinant human IL-17, recombinant canine IL-17, rmIL-17B,
rmIL‑17C, rmIL-17D, rmIL-17E, or rmIL-17F is observed.
Source
Monoclonal Rat IgG2A Clone # 50104
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
E. coli-derived recombinant mouse IL‑17
Thr22-Ala158
Accession # Q62386
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Endotoxin Level
<0.10 EU per 1 μg of the antibody by the LAL method.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
See below
Neutralization
Measured by its ability to neutralize IL‑17-induced IL‑6 secretion in the NIH‑3T3 mouse embryonic fibroblast cell line. Yao, Z. et al. (1995) Immunity 3:811. The Neutralization Dose (ND50) is typically 0.05-0.15 µg/mL in the presence of 10 ng/mL Recombinant Mouse IL‑17.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Recombinant Mouse IL-17/IL-17A antibody by Western Blot. View Larger

Detection of Recombinant Mouse IL‑17/IL‑17A by Western Blot. Western blot shows 25 ng of Recombinant Mouse IL-17/ IL-17A (Catalog # 421-ML), Recombinant Human IL-17/IL-17A (Catalog # 317-ILB), Recombinant Rat IL-17/IL-17A (Catalog # 8410-IL), and Recombinant Mouse IL-17F (Catalog # 2057-IL). PVDF Membrane was probed with 1 µg/mL of Rat Anti-Mouse IL-17/ IL-17A Monoclonal Antibody (Catalog # MAB421) followed by HRP-conjugated Anti-Rat IgG Secondary Antibody (Catalog # HAF005). A specific band was detected for IL-17/IL-17A at approximately 15 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 3.

Neutralization IL‑6 Secretion Induced by IL‑17 and Neutralization by Mouse IL‑17 Antibody. View Larger

IL‑6 Secretion Induced by IL‑17 and Neutralization by Mouse IL‑17 Antibody. Recombinant Mouse IL-17 (Catalog # 421-ML) stimulates IL-6 secretion in the NIH-3T3 mouse embryonic fibroblast cell line in a dose-dependent manner (orange line), as measured by the Mouse IL-6 Quantikine ELISA Kit (Catalog # M6000B). IL-6 secretion elicited by Recombinant Mouse IL-17 (10 ng/mL) is neutralized (green line) by increasing concentrations of Rat Anti-Mouse IL-17 Monoclonal Antibody (Catalog # MAB421). The ND50 is typically 0.05-0.15 µg/mL.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: IL-17/IL-17A

Interleukin 17 (also known as CTLA-8) is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. cDNA clones encoding IL-17 have been isolated from activated rat, mouse and human T cells. Mouse IL-17 cDNA encodes a 158 amino acid (aa) residue precursor protein with a 21 amino acid residue signal peptide that is cleaved to yield the 137 aa residue mature  IL-17. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. At the amino acid level, mIL-17 shows 57% and 87% sequence identity with herpesvirus and rat IL-17, respectively. An IL-17 specific mouse cell surface receptor (IL-17 R) has been cloned. While the expression of IL-17 mRNA is restricted to activated alpha beta TCR+CD4-CD8-T cells, the expression of mIL-17 R mRNA has been detected in virtually all cells and tissues tested. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts; the enhancement of surface expression of ICAM-1 in fibroblasts; activation of NF-kappa B and costimulation of T cell proliferation.

References
  1. Kennedy, J. et al. (1996) J. Interferon Cytokine Res. 16:611.
  2. Yao, Z. et al. (1995) J. Immunol. 155:5483.
  3. Yao, Z. et al. (1995) Immunity 3:811.
  4. Rouvier, E. et al. (1993) J. Immunol. 150:5445.
Long Name
Interleukin 17
Entrez Gene IDs
3605 (Human); 16171 (Mouse); 301289 (Rat); 449530 (Porcine); 481837 (Canine); 102119976 (Cynomolgus Monkey)
Alternate Names
CTLA8; CTLA-8; CTLA8cytotoxic T-lymphocyte-associated serine esterase 8; Cytotoxic T-lymphocyte-associated antigen 8; IL17; IL-17; IL17A; IL-17A; IL-17Acytotoxic T-lymphocyte-associated protein 8; IL-17CTLA-8; IL17interleukin-17A; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17A

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Citations for Mouse IL-17/IL-17A Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

90 Citations: Showing 1 - 10
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  1. High glucose intake exacerbates experimental autoimmune prostatitis through mitochondrial reactive oxygen species-dependent TGF-? activation-mediated Th17 differentiation
    Authors: Niu, D;Yue, SY;Wang, X;Li, WY;Zhang, L;Du, HX;Liang, CZ;
    International immunopharmacology
    Species: Murine polyomavirus strain A3
    Sample Types: In Vivo
    Applications: In vivo assay
  2. Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer's disease
    Authors: BJ Choi, MH Park, KH Park, WH Han, HJ Yoon, HY Jung, JY Hong, MR Chowdhury, KY Kim, J Lee, IS Song, M Pang, MK Choi, E Gulbins, M Reichel, J Kornhuber, CW Hong, C Kim, SH Kim, EH Schuchman, HK Jin, JS Bae
    Nature Communications, 2023-03-24;14(1):1631.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  3. Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits
    Authors: D Yu, T Li, JC Delpech, B Zhu, P Kishore, T Koshi, R Luo, KJB Pratt, G Popova, TJ Nowakowski, SA Villeda, X Piao
    Science Advances, 2022-05-06;8(18):eabm2545.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  4. Blocking the interaction between interleukin-17A and endoplasmic reticulum stress in macrophage attenuates retinal neovascularization in oxygen-induced retinopathy
    Authors: Y Wang, S Gao, S Gao, N Li, B Xie, X Shen
    Cell & bioscience, 2021-05-01;11(1):82.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  5. T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis
    Authors: RJ Napier, EJ Lee, MP Davey, EE Vance, JM Furtado, PE Snow, KA Samson, SJ Lashley, BR Brown, R Horai, MJ Mattapalli, B Xu, MC Callegan, LS Uebelhoer, CL Lancioni, RK Vehe, BA Binstadt, JR Smith, RR Caspi, HL Rosenzweig
    Nat Commun, 2020-10-26;11(1):5406.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  6. Sex differences in IL-17 contribute to chronicity in male versus female urinary tract infection
    Authors: A Zychlinsky, M Rousseau, L Lacerda Ma, T Canton, CR Consiglio, ML Albert, M Fontes, D Duffy, MA Ingersoll
    JCI Insight, 2019-05-30;5(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  7. Endogenous IL-17A mediated neutrophil infiltration by promoting chemokines expression during chlamydial lung infection
    Authors: S Qiao, H Zhang, X Zha, W Niu, J Liang, G Pang, Y Tang, T Liu, H Zhao, Y Wang, H Bai
    Microb. Pathog., 2019-01-28;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  8. B Cells Produce the Tissue-Protective Protein RELM? during Helminth Infection, which Inhibits IL-17�Expression and Limits Emphysema
    Authors: F Chen, W Wu, L Jin, A Millman, M Palma, DW El-Naccach, KE Lothstein, C Dong, KL Edelblum, WC Gause
    Cell Rep, 2018-12-04;25(10):2775-2783.e3.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Flow Cytometry, Neutralization
  9. Interferon induced protein 35 exacerbates H5N1 influenza disease through the expression of IL-12p40 homodimer
    Authors: AP Gounder, CC Yokoyama, NN Jarjour, TL Bricker, BT Edelson, ACM Boon
    PLoS Pathog., 2018-04-26;14(4):e1007001.
    Species: Mouse
    Sample Types: BALF
    Applications: Western Blot
  10. Estrogen Deficiency Promotes Cerebral Aneurysm Rupture by Upregulation of Th17 Cells and Interleukin-17A Which Downregulates E-Cadherin
    Authors: BL Hoh, K Rojas, L Lin, HZ Fazal, S Hourani, KW Nowicki, MB Schneider, K Hosaka
    J Am Heart Assoc, 2018-04-13;7(8):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  11. Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis
    Authors: CJ Lee, SJ Moon, JH Jeong, S Lee, MH Lee, SM Yoo, HS Lee, HC Kang, JY Lee, WS Lee, HJ Lee, EK Kim, JY Jhun, ML Cho, JK Min, YY Cho
    Cell Death Dis, 2018-03-14;9(3):401.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development (Capture)
  12. Galectin-9 is Critical for Mucosal Adaptive Immunity through the TH17-IgA Axis
    Authors: CC Liang, CS Li, IC Weng, HY Chen, HH Lu, CC Huang, FT Liu
    Am. J. Pathol., 2018-02-17;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  13. IL-17A Produced by Innate Lymphoid Cells Is Essential for Intestinal Ischemia-Reperfusion Injury
    Authors: M Geha, MG Tsokos, RE Bosse, T Sannikova, Y Iwakura, JJ Dalle Lucc, R De Waal Ma, GC Tsokos
    J. Immunol., 2017-09-06;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  14. IL-33 Signaling Regulates Innate IL-17A and IL-22 Production via Suppression of Prostaglandin E2 during Lung Fungal Infection
    Authors: JM Garth, KM Reeder, MS Godwin, JJ Mackel, CW Dunaway, JP Blackburn, C Steele
    J. Immunol., 2017-08-07;199(6):2140-2148.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  15. Galectin-1-Driven Tolerogenic Programs Aggravate Yersinia enterocolitica Infection by Repressing Antibacterial Immunity
    Authors: RC Davicino, SP Méndez-Hue, RJ Eliçabe, JC Stupirski, I Autenrieth, MS Di Genaro, GA Rabinovich
    J. Immunol., 2017-07-17;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  16. IL-35 induces N2 phenotype of neutrophils to promote tumor growth
    Authors: JM Zou, J Qin, YC Li, Y Wang, D Li, Y Shu, C Luo, SS Wang, G Chi, F Guo, GM Zhang, ZH Feng
    Oncotarget, 2017-05-16;8(20):33501-33514.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  17. Spirulina lipopolysaccharides inhibit tumor growth in a Toll-like receptor 4-dependent manner by altering the cytokine milieu from interleukin-17/interleukin-23 to interferon-?
    Authors: H Okuyama, A Tominaga, S Fukuoka, T Taguchi, Y Kusumoto, S Ono
    Oncol. Rep, 2017-01-02;37(2):684-694.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  18. IL-17A exacerbates diabetic retinopathy by impairing M�ller cell function via Act1 signaling
    Authors: Ao-Wang Qiu
    Exp. Mol. Med, 2016-12-16;48(12):e280.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  19. IL-17 Augments B Cell Activation in Ocular Surface Autoimmunity
    J Immunol, 2016-09-21;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  20. Interleukin-27 Mediates Susceptibility to Visceral Leishmaniasis by Suppressing the IL-17-Neutrophil Response
    Authors: Gustavo F S Quirino
    Infect Immun, 2016-07-21;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  21. Seminal plasma induces inflammation in the uterus through the ?? T/IL-17 pathway
    Authors: ZH Song, ZY Li, DD Li, WN Fang, HY Liu, DD Yang, CY Meng, Y Yang, JP Peng
    Sci Rep, 2016-04-25;6(0):25118.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  22. IL-17A Is an Important Effector of the Immune Response of the Mammary Gland to Escherichia coli Infection.
    Authors: Porcherie A, Gilbert F, Germon P, Cunha P, Trotereau A, Rossignol C, Winter N, Berthon P, Rainard P
    J Immunol, 2015-12-18;196(2):803-12.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Neutralization
  23. Interleukin-17A and Neutrophils in a Murine Model of Bird-Related Hypersensitivity Pneumonitis.
    Authors: Ishizuka M, Miyazaki Y, Masuo M, Suhara K, Tateishi T, Yasui M, Inase N
    PLoS ONE, 2015-09-14;10(9):e0137978.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  24. Dendritic Cells Regulate Treg-Th17 Axis in Obstructive Phase of Bile Duct Injury in Murine Biliary Atresia.
    Authors: Liu Y, Li K, Yang L, Tang S, Wang X, Cao G, Li S, Lei H, Zhang X
    PLoS ONE, 2015-09-01;10(9):e0136214.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  25. IL17 Mediates Pelvic Pain in Experimental Autoimmune Prostatitis (EAP).
    Authors: Murphy S, Schaeffer A, Done J, Wong L, Bell-Cohn A, Roman K, Cashy J, Ohlhausen M, Thumbikat P
    PLoS ONE, 2015-05-01;10(5):e0125623.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  26. Critical role for IL-18 in spontaneous lung inflammation caused by autophagy deficiency.
    Authors: Abdel Fattah E, Bhattacharya A, Herron A, Safdar Z, Eissa N
    J Immunol, 2015-04-17;194(11):5407-16.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  27. Neonatal Streptococcus pneumoniae infection may aggravate adulthood allergic airways disease in association with IL-17A.
    Authors: Yang B, Liu R, Yang T, Jiang X, Zhang L, Wang L, Wang Q, Luo Z, Liu E, Fu Z
    PLoS ONE, 2015-03-27;10(3):e0123010.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  28. Regulation of autoimmune germinal center reactions in lupus-prone BXD2 mice by follicular helper T cells.
    Authors: Kim Y, Lim H, Jung H, Wetsel R, Chung Y
    PLoS ONE, 2015-03-13;10(3):e0120294.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  29. Therapeutic efficacy of IL-17A antibody injection in preventing the development of colitis associated carcinogenesis in mice.
    Authors: Qi H, Yang H, Xu G, Ren J, Hua W, Shi Y, Torsvik M, Florholmen J, Cui G
    Immunobiology, 2014-09-08;220(1):54-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Blocking
  30. Systemic inflammatory response elicited by superantigen destabilizes T regulatory cells, rendering them ineffective during toxic shock syndrome.
    Authors: Tilahun A, Chowdhary V, David C, Rajagopalan G
    J Immunol, 2014-08-04;193(6):2919-30.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  31. gammadelta T cells are required for pulmonary IL-17A expression after ozone exposure in mice: role of TNFalpha.
    Authors: Mathews J, Williams A, Brand J, Wurmbrand A, Chen L, Ninin F, Si H, Kasahara D, Shore S
    PLoS ONE, 2014-05-13;9(5):e97707.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  32. Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor-alpha and interleukin-1beta but suppresses that by interleukin-17A: importance of proteolytic degradation of osteoprotegerin by lysine gingipain.
    Authors: Akiyama T, Miyamoto Y, Yoshimura K, Yamada A, Takami M, Suzawa T, Hoshino M, Imamura T, Akiyama C, Yasuhara R, Mishima K, Maruyama T, Kohda C, Tanaka K, Potempa J, Yasuda H, Baba K, Kamijo R
    J Biol Chem, 2014-04-22;289(22):15621-30.
    Species: Bacteria - Porphyromonas gingivalis
    Sample Types: Recombinant Protein
    Applications: Western Blot
  33. Leukocyte attraction by CCL20 and its receptor CCR6 in humans and mice with pneumococcal meningitis.
    Authors: Klein M, Brouwer M, Angele B, Geldhoff M, Marquez G, Varona R, Hacker G, Schmetzer H, Hacker H, Hammerschmidt S, van der Ende A, Pfister H, van de Beek D, Koedel U
    PLoS ONE, 2014-04-03;9(4):e93057.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  34. Interleukin-17A modulates circulating tumor cells in tumor draining vein of colorectal cancers and affects metastases.
    Authors: Tseng J, Yang C, Liang S, Liu R, Yang S, Lin J, Chen Y, Wu Y, Jiang J, Lin C
    Clin Cancer Res, 2014-03-27;20(11):2885-97.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  35. IL-17A produced by neutrophils protects against pneumonic plague through orchestrating IFN-gamma-activated macrophage programming.
    Authors: Bi Y, Zhou J, Yang H, Wang X, Zhang X, Wang Q, Wu X, Han Y, Song Y, Tan Y, Du Z, Yang H, Zhou D, Cui Y, Zhou L, Yan Y, Zhang P, Guo Z, Wang X, Liu G, Yang R
    J Immunol, 2013-12-13;192(2):704-13.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  36. CD8 T cells regulate allergic contact dermatitis by modulating CCR2-dependent TNF/iNOS-expressing Ly6C+ CD11b+ monocytic cells.
    Authors: Chong S, Tan K, Wong F, Chua Y, Tang Y, Ng L, Angeli V, Kemeny D
    J Invest Dermatol, 2013-09-23;134(3):666-76.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  37. IKKbeta in intestinal epithelial cells regulates allergen-specific IgA and allergic inflammation at distant mucosal sites.
    Authors: Bonnegarde-Bernard A, Jee J, Fial M, Aeffner F, Cormet-Boyaka E, Davis I, Lin M, Tome D, Karin M, Sun Y, Boyaka P
    Mucosal Immunol, 2013-07-10;7(2):257-67.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Functional Assay
  38. Galectin-3 negatively regulates dendritic cell production of IL-23/IL-17-axis cytokines in infection by Histoplasma capsulatum.
    Authors: Wu S, Yu J, Liu F, Miaw S, Wu-Hsieh B
    J Immunol, 2013-03-01;190(7):3427-37.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  39. Involvement of IL-9 in Th17-associated inflammation and angiogenesis of psoriasis.
    Authors: Singh T, Schon M, Wallbrecht K, Gruber-Wackernagel A, Wang X, Wolf P
    PLoS ONE, 2013-01-15;8(1):e51752.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  40. Transcription factors GATA-3 and RORgammat are important for determining the phenotype of allergic airway inflammation in a murine model of asthma.
    Authors: Ano S, Morishima Y, Ishii Y, Yoh K, Yageta Y, Ohtsuka S, Matsuyama M, Kawaguchi M, Takahashi S, Hizawa N
    J Immunol, 2013-01-04;190(3):1056-65.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  41. Early IL-17 production by intrahepatic T cells is important for adaptive immune responses in viral hepatitis.
    Authors: Hou L, Jie Z, Desai M, Liang Y, Soong L, Wang T, Sun J
    J Immunol, 2012-12-10;190(2):621-9.
    Species: Mouse
    Sample Types: In Vivo, Tissue Homogenates
    Applications: Neutralization, Western Blot
  42. Salmonella enterica induces joint inflammation and expression of interleukin-17 in draining lymph nodes early after onset of enterocolitis in mice.
    Authors: Noto Llana M, Sarnacki SH, Vazquez MV, Gartner AS, Giacomodonato MN, Cerquetti MC
    Infect. Immun., 2012-04-09;80(6):2231-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  43. IL-23 is required for long-term control of Mycobacterium tuberculosis and B cell follicle formation in the infected lung.
    Authors: Khader SA, Guglani L, Rangel-Moreno J
    J. Immunol., 2011-10-14;187(10):5402-7.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  44. TLR2-mediated production of IL-27 and chemokines by respiratory epithelial cells promotes bleomycin-induced pulmonary fibrosis in mice.
    Authors: Kim HS, Go H, Akira S, Chung DH
    J. Immunol., 2011-09-19;187(8):4007-17.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  45. Differential effects of peptidoglycan recognition proteins on experimental atopic and contact dermatitis mediated by Treg and Th17 cells.
    Authors: Park SY, Gupta D, Kim CH
    PLoS ONE, 2011-09-16;6(9):e24961.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  46. Innate immune responses to systemic Acinetobacter baumannii infection in mice: neutrophils, but not interleukin-17, mediate host resistance.
    Authors: Breslow JM, Meissler JJ, Hartzell RR
    Infect. Immun., 2011-05-16;79(8):3317-27.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  47. Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy.
    Authors: Ma Y, Aymeric L, Locher C, Mattarollo SR, Delahaye NF, Pereira P, Boucontet L, Apetoh L, Ghiringhelli F, Casares N, Lasarte JJ, Matsuzaki G, Ikuta K, Ryffel B, Benlagha K, Tesniere A, Ibrahim N, Dechanet-Merville J, Chaput N, Smyth MJ, Kroemer G, Zitvogel L
    J. Exp. Med., 2011-03-07;208(3):491-503.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  48. A critical function of Th17 proinflammatory cells in the development of atherosclerotic plaque in mice.
    Authors: Gao Q, Jiang Y, Ma T, Zhu F, Gao F, Zhang P, Guo C, Wang Q, Wang X, Ma C, Zhang Y, Chen W, Zhang L
    J. Immunol., 2010-10-15;185(10):5820-7.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  49. Molecular immune responses to aerosol challenge with Francisella tularensis in mice inoculated with live vaccine candidates of varying efficacy.
    Authors: Shen H, Harris G, Chen W, Sjostedt A, Ryden P, Conlan W
    PLoS ONE, 2010-10-12;5(10):e13349.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  50. Protective role of interleukin-17 in murine NKT cell-driven acute experimental hepatitis.
    Authors: Wondimu Z, Santodomingo-Garzon T, Le T, Swain MG
    Am. J. Pathol., 2010-09-16;177(5):2334-46.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  51. Lack of TNFR p55 results in heightened expression of IFN-gamma and IL-17 during the development of reactive arthritis.
    Authors: Elicabe RJ, Cargnelutti E, Serer MI, Stege PW, Valdez SR, Toscano MA, Rabinovich GA, Di Genaro MS
    J. Immunol., 2010-09-01;185(7):4485-95.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  52. Th17 immune responses contribute to the pathophysiology of aplastic anemia.
    Authors: de Latour RP, Visconte V, Takaku T
    Blood, 2010-08-23;116(20):4175-84.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  53. Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung.
    Authors: Redford PS, Boonstra A, Read S, Pitt J, Graham C, Stavropoulos E, Bancroft GJ, O'Garra A
    Eur. J. Immunol., 2010-08-01;40(8):2200-10.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  54. Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis.
    Authors: Cruz A, Fraga AG, Fountain JJ, Rangel-Moreno J, Torrado E, Saraiva M, Pereira DR, Randall TD, Pedrosa J, Cooper AM, Castro AG
    J. Exp. Med., 2010-07-12;207(8):1609-16.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  55. IL-22 defines a novel immune pathway of antifungal resistance.
    Authors: De Luca A, Zelante T, D'Angelo C
    Mucosal Immunol, 2010-05-05;3(4):361-73.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  56. IL-17A-producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis.
    Authors: Lo Re S, Dumoutier L, Couillin I, Van Vyve C, Yakoub Y, Uwambayinema F, Marien B, van den Brule S, Van Snick J, Uyttenhove C, Ryffel B, Renauld JC, Lison D, Huaux F
    J. Immunol., 2010-04-26;184(11):6367-77.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  57. Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease.
    Authors: Horvat JC, Starkey MR, Kim RY, Beagley KW, Preston JA, Gibson PG, Foster PS, Hansbro PM
    J. Immunol., 2010-03-12;184(8):4159-69.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  58. IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury.
    Authors: Li L, Huang L, Vergis AL, Ye H, Bajwa A, Narayan V, Strieter RM, Rosin DL, Okusa MD
    J. Clin. Invest., 2009-12-14;120(1):331-42.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  59. Encephalitogenicity of complete Freund's adjuvant relative to CpG is linked to induction of Th17 cells.
    Authors: Tigno-Aranjuez JT, Jaini R, Tuohy VK, Lehmann PV, Tary-Lehmann M
    J. Immunol., 2009-10-07;183(9):5654-61.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  60. IL-17/Th17 promotes type 1 T cell immunity against pulmonary intracellular bacterial infection through modulating dendritic cell function.
    Authors: Bai H, Cheng J, Gao X, Joyee AG, Fan Y, Wang S, Jiao L, Yao Z, Yang X
    J. Immunol., 2009-10-07;183(9):5886-95.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  61. Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13.
    Authors: He R, Kim HY, Yoon J, Oyoshi MK, MacGinnitie A, Goya S, Freyschmidt EJ, Bryce P, McKenzie AN, Umetsu DT, Oettgen HC, Geha RS
    J. Allergy Clin. Immunol., 2009-10-01;124(4):761-70.e1.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  62. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses.
    Authors: Wu S, Rhee KJ, Albesiano E, Rabizadeh S, Wu X, Yen HR, Huso DL, Brancati FL, Wick E, McAllister F, Housseau F, Pardoll DM, Sears CL
    Nat. Med., 2009-08-23;15(9):1016-22.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  63. Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response.
    Authors: Oyoshi MK, Elkhal A, Kumar L, Scott JE, Koduru S, He R, Leung DY, Howell MD, Oettgen HC, Murphy GF, Geha RS
    Proc. Natl. Acad. Sci. U.S.A., 2009-08-17;106(35):14954-9.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Neutralization
  64. Interleukin-17-producing gammadelta+ T cells protect NOD mice from type 1 diabetes through a mechanism involving transforming growth factor-beta.
    Authors: Han G, Wang R, Chen G
    Immunology, 2009-08-04;129(2):197-206.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  65. Peroxisome proliferator-activated receptor gamma agonist down-regulates IL-17 expression in a murine model of allergic airway inflammation.
    Authors: Park SJ, Lee KS, Kim SR, Min KH, Choe YH, Moon H, Chae HJ, Yoo WH, Lee YC
    J. Immunol., 2009-07-29;183(5):3259-67.
    Species: Mouse
    Sample Types: In Vivo, Tissue Homogenates
    Applications: Neutralization, Western Blot
  66. A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum.
    Authors: Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton MT, Arulanandam B, Zhang J, Zhong G
    J. Immunol., 2009-06-19;183(2):1291-300.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  67. Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells.
    Authors: Yuan X, Ansari MJ, D'Addio F, Paez-Cortez J, Schmitt I, Donnarumma M, Boenisch O, Zhao X, Popoola J, Clarkson MR, Yagita H, Akiba H, Freeman GJ, Iacomini J, Turka LA, Glimcher LH, Sayegh MH
    Proc. Natl. Acad. Sci. U.S.A., 2009-06-15;106(26):10734-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  68. Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge.
    Authors: Hamada H, Garcia-Hernandez Mde L, Reome JB, Misra SK, Strutt TM, McKinstry KK, Cooper AM, Swain SL, Dutton RW
    J. Immunol., 2009-03-15;182(6):3469-81.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  69. Interleukin-17 causes neutrophil mediated inflammation in ovalbumin-induced uveitis in DO11.10 mice.
    Authors: Zhang Z, Zhong W, Spencer D, Chen H, Lu H, Kawaguchi T, Rosenbaum JT
    Cytokine, 2009-02-28;46(1):79-91.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  70. Anti-inflammatory effects of IL-17A on Helicobacter pylori-induced gastritis.
    Authors: Otani K, Watanabe T, Tanigawa T, Okazaki H, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Oshitani N, Arakawa T
    Biochem. Biophys. Res. Commun., 2009-02-26;382(2):252-8.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  71. Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression.
    Authors: Chauhan SK, El Annan J, Ecoiffier T, Goyal S, Zhang Q, Saban DR, Dana R
    J. Immunol., 2009-02-01;182(3):1247-52.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  72. Promotion of the local differentiation of murine Th17 cells by synovial macrophages during acute inflammatory arthritis.
    Authors: Egan PJ, van Nieuwenhuijze A, Campbell IK, Wicks IP
    Arthritis Rheum., 2008-12-01;58(12):3720-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  73. Interleukin-1 drives pathogenic Th17 cells during spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice.
    Authors: Koenders MI, Devesa I, Marijnissen RJ, Abdollahi-Roodsaz S, Boots AM, Walgreen B, di Padova FE, Nicklin MJ, Joosten LA, van den Berg WB
    Arthritis Rheum., 2008-11-01;58(11):3461-70.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  74. CD8+ Th17 mediate costimulation blockade-resistant allograft rejection in T-bet-deficient mice.
    Authors: Burrell BE, Csencsits K, Lu G, Grabauskiene S, Bishop DK
    J. Immunol., 2008-09-15;181(6):3906-14.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  75. Interferon-gamma regulates idiopathic pneumonia syndrome, a Th17+CD4+ T-cell-mediated graft-versus-host disease.
    Authors: Mauermann N, Burian J, von Garnier C, Dirnhofer S, Germano D, Schuett C, Tamm M, Bingisser R, Eriksson U, Hunziker L
    Am. J. Respir. Crit. Care Med., 2008-05-29;178(4):379-88.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  76. A distinct subset of natural killer T cells produces IL-17, contributing to airway infiltration of neutrophils but not to airway hyperreactivity.
    Authors: Lee KA, Kang MH, Lee YS, Kim YJ, Kim DH, Ko HJ, Kang CY
    Cell. Immunol., 2008-04-18;251(1):50-5.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  77. Lack of Toll IL-1R8 exacerbates Th17 cell responses in fungal infection.
    Authors: Bozza S, Zelante T, Moretti S, Bonifazi P, DeLuca A, D'Angelo C, Giovannini G, Garlanda C, Boon L, Bistoni F, Puccetti P, Mantovani A, Romani L
    J. Immunol., 2008-03-15;180(6):4022-31.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  78. Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase.
    Authors: Iwanami K, Matsumoto I, Tanaka-Watanabe Y, Inoue A, Mihara M, Ohsugi Y, Mamura M, Goto D, Ito S, Tsutsumi A, Kishimoto T, Sumida T
    Arthritis Rheum., 2008-03-01;58(3):754-63.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  79. Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease.
    Authors: D'Angelo C, Segal BH
    Nature, 2008-01-10;451(7175):211-5.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  80. Exacerbation of antigen-induced arthritis in IFN-gamma-deficient mice as a result of unrestricted IL-17 response.
    Authors: Irmler IM, Gajda M, Brauer R
    J. Immunol., 2007-11-01;179(9):6228-36.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  81. IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance.
    Authors: Zelante T, De Luca A, Bonifazi P, Montagnoli C, Bozza S, Moretti S, Belladonna ML, Vacca C, Conte C, Mosci P, Bistoni F, Puccetti P, Kastelein RA, Kopf M, Romani L
    Eur. J. Immunol., 2007-10-01;37(10):2695-706.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  82. Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity.
    Authors: Harris TJ, Grosso JF, Yen HR, Xin H, Kortylewski M, Albesiano E, Hipkiss EL, Getnet D, Goldberg MV, Maris CH, Housseau F, Yu H, Pardoll DM, Drake CG
    J. Immunol., 2007-10-01;179(7):4313-7.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  83. Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge.
    Authors: He R, Oyoshi MK, Jin H, Geha RS
    Proc. Natl. Acad. Sci. U.S.A., 2007-09-24;104(40):15817-22.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  84. IL-23 enhances host defense against vaccinia virus infection via a mechanism partly involving IL-17.
    Authors: Kohyama S, Ohno S, Isoda A, Moriya O, Belladonna ML, Hayashi H, Iwakura Y, Yoshimoto T, Akatsuka T, Matsui M
    J. Immunol., 2007-09-15;179(6):3917-25.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  85. Resident Vdelta1+ gammadelta T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production.
    Authors: Shibata K, Yamada H, Hara H, Kishihara K, Yoshikai Y
    J. Immunol., 2007-04-01;178(7):4466-72.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  86. T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways.
    Authors: Fujiwara M, Hirose K, Kagami S, Takatori H, Wakashin H, Tamachi T, Watanabe N, Saito Y, Iwamoto I, Nakajima H
    J. Allergy Clin. Immunol., 2007-03-01;119(3):662-70.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  87. Functional relevance of the IL-23-IL-17 axis in lungs in vivo.
    Authors: Ivanov S, Bozinovski S, Bossios A, Valadi H, Vlahos R, Malmhall C, Sjostrand M, Kolls JK, Anderson GP, Linden A
    Am. J. Respir. Cell Mol. Biol., 2006-12-01;36(4):442-51.
    Species: Mouse
    Sample Types:
    Applications: Neutralization
  88. Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation.
    Authors: Sergejeva S, Ivanov S, Lotvall J, Linden A
    Am. J. Respir. Cell Mol. Biol., 2005-05-18;33(3):248-53.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  89. Inhibition of interleukin-17 prevents the development of arthritis in vaccinated mice challenged with Borrelia burgdorferi.
    Authors: Burchill MA, Nardelli DT, England DM, DeCoster DJ, Christopherson JA, Callister SM, Schell RF
    Infect. Immun., 2003-06-01;71(6):3437-42.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  90. Endogenous IL-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways.
    Authors: Miyamoto M, Prause O, Sjostrand M, Laan M, Lotvall J, Linden A
    J. Immunol., 2003-05-01;170(9):4665-72.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: ELISpot Development, ICC, Neutralization

FAQs

  1. Does Mouse IL-17/IL-17A antibody (catalog # MAB421) cross-react with Rat IL-17A?

    • Mouse IL-17/IL-17A antibody, catalog # MAB421, was tested against recombinant Rat IL-17A (catalog # 8410-IL ) in a Direct ELISA assay. 100% cross-rectivity was observed to recombinant Rat IL-17A.

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Mouse IL-17/IL-17A Antibody
By Anonymous on 08/09/2021
Application: WB Sample Tested: Fibroblast-like synoviocytes,fibroblasts Species: Mouse
Western Blot Mouse IL-17/IL-17A Antibody MAB421
Mouse IL-17/IL-17A Antibody
By Leslie Priddy on 04/13/2018
Application: IHC Sample Tested: Tumor cell lyastes Species: Mouse