Mouse Neprilysin/CD10 Antibody Summary
Tyr52-Trp750
Accession # AAA37386
Applications
Mouse Neprilysin/CD10 Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Neprilysin/CD10 in Mouse Brain. Neprilysin/CD10 was detected in perfusion fixed frozen sections of mouse brain (glial cell in hippocampus) using 15 µg/mL Goat Anti-Mouse Neprilysin/CD10 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1126) overnight at 4 °C. Tissue was stained (red) and counterstained (green). View our protocol for Fluorescent IHC Staining of Frozen Tissue Sections.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Neprilysin/CD10
Neprilysin (NEP, neutral endopeptidase 24.11, EC 3.4.24.11) is a zinc metallopeptidase expressed at the cell surface of a variety of cells. The enzyme functions both as an endopeptidase with a thermolysin-like specificity and as a dipeptidylcarboxypeptidase. NEP has been shown to be involved in the degradation of enkephalins in the mammalian brain and the inactivation of circulating atrial natriuretic peptide (1, 2). NEP has also been identified as the common acute lymphoblastic leukemia antigen (CALLA), and to be expressed on the surface of lymphocytes in some disease states (3). These and other observations have resulted in considerable clinical interest in NEP as a potential target for analgesics and antihypertensive drugs. NEP is also a major degrading enzyme of amyloid beta peptide (A beta ) in the brain, indicating that down-regulation of NEP activity, which could be caused by aging, can contribute to the development of Alzheimer’s disease by promoting A beta accumulation (4).
- Malfroy, B. et al. (1978) Nature 276:523.
- Kenny, A.J. and S.L. Stephenson (1988) FEBS Lett. 232:1.
- LeTarte, M. et al. (1988) J. Exp. Med. 168:1247.
- Itwata, N. et al. (2001) Science 292:1550.
Product Datasheets
Citations for Mouse Neprilysin/CD10 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Tianma-Gouteng pair ameliorates the cognitive deficits on two transgenic mouse models of Alzheimer's disease
Authors: Zhong, M;Xu, QQ;Hu, Z;Yang, W;Lin, ZX;Xian, YF;
Journal of ethnopharmacology
Species: Transgenic Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
Somatostatin slows Abeta plaque deposition in aged APPNL-F/NL-F mice by blocking Abeta aggregation
Authors: D Williams, BQ Yan, H Wang, L Negm, C Sackmann, C Verkuyl, V Rezai-Stev, S Eid, N Vediya, C Sato, JC Watts, H Wille, G Schmitt-Ul
Scientific Reports, 2023-02-09;13(1):2337.
Species: Mouse
Sample Types: Tissue Homogenates, Whole Tissue
Applications: IHC, Western Blot -
Anti-malaria drug artesunate prevents development of amyloid-beta pathology in mice by upregulating PICALM at the blood-brain barrier
Authors: K Kisler, AP Sagare, D Lazic, S Bazzi, E Lawson, CJ Hsu, Y Wang, A Ramanathan, AR Nelson, Z Zhao, BV Zlokovic
Molecular Neurodegeneration, 2023-01-27;18(1):7.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
Blockade of the natriuretic peptide clearance receptor attenuates proteinuria in a mouse model of focal segmental glomerulosclerosis
Authors: L Wang, Y Tang, AF Buckley, RF Spurney
Physiological Reports, 2021-11-01;9(21):e15095.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot -
Nano-Honokiol ameliorates the cognitive deficits in TgCRND8 mice of Alzheimer's disease via inhibiting neuropathology and modulating gut microbiota
Authors: C Qu, QP Li, ZR Su, SP Ip, QJ Yuan, YL Xie, QQ Xu, W Yang, YF Huang, YF Xian, ZX Lin
Journal of advanced research, 2021-03-31;35(0):231-243.
Species: Rat
Sample Types: Tissue Homogenates
Applications: Western Blot -
PD-L1+ neutrophils contribute to injury-induced infection susceptibility
Authors: A Thanabalas, AJ Chiang, C Morehouse, M Camara, S Hawkins, AE Keller, AC Koksal, CS Caceres, AA Berlin, N Holoweckyj, VN Takahashi, L Cheng, M de Los Rey, M Pelletier, AC Patera, B Sellman, S Hess, M Marelli, CC Boo, TS Cohen, A DiGiandome
Science Advances, 2021-03-05;7(10):.
Species: Mouse
Sample Types: Serum
Applications: ELISA Capture -
Phytohormone Abscisic Acid Improves Memory Impairment and Reduces Neuroinflammation in 5xFAD Mice by Upregulation of LanC-Like Protein 2
Authors: SH Jeon, N Kim, YJ Ju, MS Gee, D Lee, JK Lee
Int J Mol Sci, 2020-11-10;21(22):.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice
Authors: K Kidana, T Tatebe, K Ito, N Hara, A Kakita, T Saito, S Takatori, Y Ouchi, T Ikeuchi, M Makino, TC Saido, M Akishita, T Iwatsubo, Y Hori, T Tomita
EMBO Mol Med, 2018-03-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: IHC-Fr -
Pericyte loss influences Alzheimer-like neurodegeneration in mice.
Authors: Sagare A, Bell R, Zhao Z, Ma Q, Winkler E, Ramanathan A, Zlokovic B
Nat Commun, 2013-01-01;4(0):2932.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
Expression of neprilysin in skeletal muscle reduces amyloid burden in a transgenic mouse model of Alzheimer disease.
Authors: Liu Y, Studzinski C, Beckett T, Guan H, Hersh MA, Murphy MP, Klein R, Hersh LB
Mol. Ther., 2009-05-26;17(8):1381-6.
Species: Mouse
Sample Types: Tissue Homogenates, Whole Tissue
Applications: IHC-P, Western Blot
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