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Mouse/Rat FGF-21 Quantikine ELISA Kit

Catalog #: MF2100
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Mouse/Rat FGF-21 ELISA Cell Culture Supernate Standard Curve
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Summary Precision Recovery Linearity Data Examples Product Datasheets Preparation and Storage Background Related Research Areas

Mouse/Rat FGF-21 Quantikine ELISA Kit Summary

Assay Type
Solid Phase Sandwich ELISA
Format
96-well strip plate
Assay Length
4.5 hours
Sample Type & Volume Required Per Well
Cell Culture Supernates (50 uL), Serum (25 uL), EDTA Plasma (25 uL), Heparin Plasma (25 uL)
Sensitivity
13.4 pg/mL
Assay Range
31.3 - 2,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma)
Specificity
Natural and recombinant mouse and rat FGF-21
Cross-reactivity
< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
Interference
No significant interference observed with available related molecules.

Product Summary

The Quantikine Mouse/Rat FGF-21 immunoassay is a 4.5 hour solid-phase ELISA designed to measure FGF-21 in mouse or rat cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant mouse FGF-21 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant mouse FGF-21. Results obtained using natural mouse or rat FGF-21 showed dose response curves that were parallel to the standard curves obtained using the Quantikine mouse kit standards. These results indicate that this kit can be used to determine relative mass values for natural FGF-21.

Precision

Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision
Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision

Cell Culture Supernates

Intra-Assay Precision Inter-Assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 40 40 40
Mean (pg/mL) 84.4 226 754 94.5 231 745
Standard Deviation 5.24 9.6 19.7 6.61 10.8 31
CV% 6.2 4.2 2.6 7 4.7 4.2

Serum, EDTA Plasma, Heparin Plasma

Intra-Assay Precision Inter-Assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 40 40 40
Mean (pg/mL) 118 317 1032 120 302 977
Standard Deviation 7.35 13.5 25.2 8.91 18 65.9
CV% 6.2 4.3 2.4 7.4 6 6.7

Recovery

The recovery of FGF-21 spiked to levels throughout the range of the assay in various matrices was evaluated.

Sample Type Average % Recovery Range %
Mouse Cell Culture Samples (n=6) 96 88-101
Mouse EDTA Plasma (n=4) 97 86-104
Mouse Heparin Plasma (n=4) 93 83-101
Mouse Serum (n=4) 95 83-103
Rat Cell Culture Samples (n=2) 91 87-95
Rat EDTA Plasma (n=4) 101 93-119
Rat Heparin Plasma (n=4) 97 94-104
Rat Serum (n=4) 100 93-108

Linearity

To assess the linearity of the assay, samples spiked with high concentrations of FGF-21 in each matrix were diluted with the appropriate Calibrator Diluent and assayed.
Mouse/Rat FGF-21 ELISA Linearity
Mouse/Rat FGF-21 ELISA Linearity

Scientific Data

N/A Mouse/Rat FGF-21 ELISA Cell Culture Supernate Standard Curve View Larger

Mouse/Rat FGF-21 ELISA Cell Culture Supernate Standard Curve

N/A Mouse/Rat FGF-21 ELISA Serum/Plasma Standard Curve View Larger

Mouse/Rat FGF-21 ELISA Serum/Plasma Standard Curve

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Preparation and Storage

Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: FGF-21

FGF-21 (Fibroblast Growth Factor 21) is a member of an FGF subfamily that also includes FGF-19 and FGF-23. FGF-19 subfamily members lack a heparin binding domain, enabling them to freely circulate as endocrine factors and diffuse within tissues. FGF-21 signals through Klotho beta in complex with FGF receptors. It regulates cellular metabolism including glucose uptake in adipocytes and cellular sensitivity to insulin. It is basally expressed in the pancreas, thymus, liver, and adipose tissue and is upregulated in liver, muscle, and fat in obesity and diabetes. FGF-21 also plays a role in cell survival and proliferation, mesenchymal stem cell differentiation, circadian rhythm, and controlling reproductive capacity.

Long Name:
Fibroblast Growth Factor 21
Entrez Gene IDs:
26291 (Human); 56636 (Mouse)
Alternate Names:
FGF21; FGF-21; fibroblast growth factor 21
⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Assay Procedure

Refer to the product for complete assay procedure.

Bring all reagents and samples to room temperature before use. It is recommended that all samples, standards, and controls be assayed in duplicate.
  1.   Prepare all reagents, standard dilutions, and samples as directed in the product insert.
  2.   Remove excess microplate strips from the plate frame, return them to the foil pouch containing the desiccant pack, and reseal.
    3. 50 µL Assay Diluent
  3.   Add 50 µL of Assay Diluent to each well.
    4. 50 µL Standard, Control, or Sample
  4.   Add 50 µL of Standard, Control, or sample to each well. Cover with a plate sealer, and incubate at room temperature for 2 hours.
  5.   Aspirate each well and wash, repeating the process 4 times for a total of 5 washes.
    6. 100 µL Conjugate
  6.   Add 100 µL of Conjugate to each well. Cover with a new plate sealer, and incubate at room temperature for 2 hours.
  7.   Aspirate and wash 5 times.
    8. 100 µL Substrate Solution
  8.   Add 100 µL Substrate Solution to each well. Incubate at room temperature for 30 minutes. PROTECT FROM LIGHT.
    9. 100 µL Stop Solution
  9.   Add 100 µL of Stop Solution to each well. Read at 450 nm within 30 minutes. Set wavelength correction to 540 nm or 570 nm.

Citations for Mouse/Rat FGF-21 Quantikine ELISA Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

108 Citations: Showing 1 - 10
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  1. FGF21 and autophagy coordinately counteract kidney disease progression during aging and obesity
    Authors: Minami, S;Sakai, S;Yamamoto, T;Takabatake, Y;Namba-Hamano, T;Takahashi, A;Matsuda, J;Yonishi, H;Nakamura, J;Maeda, S;Matsui, S;Matsui, I;Isaka, Y;
    Autophagy
    Species: Mouse
    Sample Types: Plasma
  2. Development of muscle weakness in a mouse model of critical illness: does fibroblast growth factor 21 play a role?
    Authors: Vankrunkelsven, W;Thiessen, S;Derde, S;Vervoort, E;Derese, I;Pintelon, I;Matheussen, H;Jans, A;Goossens, C;Langouche, L;Van den Berghe, G;Vanhorebeek, I;
    Skeletal muscle
    Species: Mouse
    Sample Types: Plasma
  3. A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy
    Authors: Southwell, N;Primiano, G;Nadkarni, V;Attarwala, N;Beattie, E;Miller, D;Alam, S;Liparulo, I;Shurubor, YI;Valentino, ML;Carelli, V;Servidei, S;Gross, SS;Manfredi, G;Chen, Q;D'Aurelio, M;
    EMBO molecular medicine
    Species: Mouse
    Sample Types: Plasma
  4. Mapping the metabolic reprogramming induced by sodium-glucose cotransporter 2 inhibition
    Authors: A Kogot-Levi, Y Riahi, I Abramovich, O Mosenzon, B Agranovich, L Kadosh, R Ben-Harous, D Kleiman, L Hinden, E Cerasi, D Ben-Zvi, E Bernal-Miz, J Tam, E Gottlieb, G Leibowitz
    JCI Insight, 2023-04-10;0(0):.
    Species: Mouse
    Sample Types: Serum
  5. Activation of brown adipose tissue by a low-protein diet ameliorates hyperglycemia in a diabetic lipodystrophy mouse model
    Authors: M Munoz, A Zamudio, M McCann, V Gil, P Xu, CW Liew
    Research square, 2023-03-31;0(0):.
    Species: Mouse
    Sample Types: Plasma
  6. Reduced insulin signaling in neurons induces sex-specific health benefits
    Authors: M Baghdadi, T Nespital, A Mesaros, S Buschbaum, DJ Withers, S Grönke, L Partridge
    Science Advances, 2023-02-22;9(8):eade8137.
    Species: Mouse
    Sample Types: Plasma
  7. Restricting dietary protein or dietary isoleucine improves metabolic health in aged mice
    Authors: CY Yeh, LCS Chini, MS Gallagher, JW Davidson, IT Freichels, MF Calubag, AC Rodgers, CL Green, R Babygirija, MM Sonsalla, HH Pak, M Trautman, TA Hacker, J Simcox, DW Lamming
    bioRxiv : the preprint server for biology, 2023-02-07;0(0):.
    Species: Mouse
    Sample Types: Plasma
  8. Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups
    Authors: T Hirabayash, M Kawaguchi, S Harada, M Mouri, R Takamiya, Y Miki, H Sato, Y Taketomi, K Yokoyama, T Kobayashi, SM Tokuoka, Y Kita, E Yoda, S Hara, K Mikami, Y Nishito, N Kikuchi, R Nakata, M Kaneko, H Kiyonari, K Kasahara, T Aiba, K Ikeda, T Soga, M Kurano, Y Yatomi, M Murakami
    Cell Reports, 2023-01-30;42(2):111940.
    Species: Mouse
    Sample Types: Serum
  9. MRL/MpJ Mice Resist to Age-Related and Long-Term Ovariectomy-Induced Bone Loss: Implications for Bone Regeneration and Repair
    Authors: X Gao, X Sun, H Cheng, JJ Ruzbarsky, M Mullen, M Huard, J Huard
    International Journal of Molecular Sciences, 2023-01-25;24(3):.
    Species: Mouse
    Sample Types: Serum
  10. MRL/MpJ Mice Resist to Age-Related and Long-Term Ovariectomy-Induced Bone Loss: Implications for Bone Regeneration and Repair
    Authors: X Gao, X Sun, H Cheng, JJ Ruzbarsky, M Mullen, M Huard, J Huard
    International Journal of Molecular Sciences, 2023;24(3):.
    Species: Mouse
    Sample Types: Serum
  11. SMP30-mediated synthesis of vitamin C activates the liver PPARalpha/FGF21 axis to regulate thermogenesis in mice
    Authors: B Lee, HJ An, DH Kim, MK Lee, HH Jeong, KW Chung, Y Go, AY Seo, IY Kim, JK Seong, BP Yu, J Lee, E Im, IK Lee, MS Lee, KI Yamada, HY Chung
    Experimental & Molecular Medicine, 2022-11-25;0(0):.
    Species: Transgenic Mouse
    Sample Types: Serum
  12. SIRT7 Deficiency Protects against Aging-Associated Glucose Intolerance and Extends Lifespan in Male Mice
    Authors: T Mizumoto, T Yoshizawa, Y Sato, T Ito, T Tsuyama, A Satoh, S Araki, K Tsujita, M Tamura, Y Oike, K Yamagata
    Cells, 2022-11-15;11(22):.
    Species: Mouse
    Sample Types: Serum
  13. Social stress alters sleep in FGF21-deficient mice
    Authors: S Hokari, S Chikahisa, T Shiuchi, Y Nakayama, M Konishi, S Nishino, N Itoh, H Séi
    Brain research bulletin, 2022-10-13;0(0):.
    Species: Mouse
    Sample Types: Plasma
  14. Combined genetic deletion of GDF15 and FGF21 has modest effects on body weight, hepatic steatosis and insulin resistance in high fat fed mice
    Authors: S Patel, A Haider, A Alvarez-Gu, G Bidault, JS El-Sayed M, E Guiu-Jurad, JA Tadross, J Warner, J Harrison, S Virtue, F Scurria, I Zvetkova, M Blüher, KS Small, S O'Rahilly, DB Savage
    Molecular Metabolism, 2022-09-02;65(0):101589.
    Species: Mouse
    Sample Types: Plasma
  15. Multiomics assessment of dietary protein titration reveals altered hepatic glucose utilization
    Authors: MR MacArthur, SJ Mitchell, KS Chadaideh, JH Treviño-Vi, J Jung, KC Kalafut, JS Reynolds, CG Mann, KM Trocha, M Tao, TZ Aye Cho, A Koontanate, V Yeliseyev, L Bry, A Longchamp, CK Ozaki, CA Lewis, RN Carmody, JR Mitchell
    Cell Reports, 2022-08-16;40(7):111187.
    Species: Mouse
    Sample Types: Serum
  16. Clinically Relevant Dose of Pemafibrate, a Novel Selective Peroxisome Proliferator-Activated Receptor alpha Modulator (SPPARMalpha), Lowers Serum Triglyceride Levels by Targeting Hepatic PPARalpha in Mice
    Authors: Z Zhang, P Diao, X Zhang, T Nakajima, T Kimura, N Tanaka
    Oncogene, 2022-07-11;10(7):.
    Species: Mouse
    Sample Types: Serum
  17. FGF21-FGFR4 signaling in cardiac myocytes promotes concentric cardiac hypertrophy in mouse models of diabetes
    Authors: C Yanucil, D Kentrup, X Li, A Grabner, K Schramm, EC Martinez, J Li, I Campos, B Czaya, K Heitman, D Westbrook, AR Wende, A Sloan, JM Roche, A Fornoni, MS Kapiloff, C Faul
    Scientific Reports, 2022-05-05;12(1):7326.
    Species: Mouse
    Sample Types: Serum
  18. FGF21 modulates mitochondrial stress response in cardiomyocytes only under mild mitochondrial dysfunction
    Authors: M Croon, K Szczepanow, M Popovic, C Lienkamp, K Senft, CP Brandschei, T Bock, L Gnatzy-Fei, A Ashurov, RJ Acton, H Kaul, C Pujol, S Rosenkranz, M Krüger, A Trifunovic
    Science Advances, 2022-04-06;8(14):eabn7105.
    Species: Transgenic Mouse
    Sample Types: Serum
  19. eNAMPT actions through nucleus accumbens NAD+/SIRT1 link increased adiposity with sociability deficits programmed by peripuberty stress
    Authors: L Morató, S Astori, I Zalachoras, J Rodrigues, S Ghosal, W Huang, I Guillot de, J Grosse, O Zanoletti, L Cao, J Auwerx, C Sandi
    Science Advances, 2022-03-02;8(9):eabj9109.
    Species: Mouse
    Sample Types: Plasma
  20. Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis
    Authors: D Sáenz de U, X Buqué, B Porteiro, C Folgueira, A Mora, TC Delgado, E Prieto-Fer, P Olaizola, B Gómez-Sant, M Apodaka-Bi, F González-R, A Nieva-Zulu, M Ruiz de Ga, N Goikoetxea, JL García-Rod, V Gutierrez, I Aurrekoetx, V Montalvo-R, EM Novoa, I Martín-Gue, M Varela-Rey, S Bhanot, R Lee, JM Banales, WK Syn, G Sabio, ML Martínez-C, R Nogueiras, P Aspichueta
    Nature Communications, 2022-03-01;13(1):1096.
    Species: Mouse
    Sample Types: Serum
  21. Long-Term Dietary Taurine Lowers Plasma Levels of Cholesterol and Bile Acids
    Authors: R Tagawa, M Kobayashi, M Sakurai, M Yoshida, H Kaneko, Y Mizunoe, Y Nozaki, N Okita, Y Sudo, Y Higami
    International Journal of Molecular Sciences, 2022-02-04;23(3):.
    Species: Mouse
    Sample Types: Plasma
  22. Plant and marine N3-PUFA regulation of fatty acid trafficking along the adipose tissue-liver axis varies according to nutritional state
    Authors: A Rajna, LH Brown, SM Frangos, M Gonzalez-S, B Hucik, C Wang, DC Wright, DM Mutch
    The Journal of nutritional biochemistry, 2022-01-10;102(0):108940.
    Species: Mouse
    Sample Types: Plasma
  23. BAd-CRISPR: inducible gene knockout in interscapular brown adipose tissue of adult mice
    Authors: SM Romanelli, KT Lewis, A Nishii, AC Rupp, Z Li, H Mori, RL Schill, BS Learman, CJ Rhodes, OA MacDougald
    The Journal of Biological Chemistry, 2021-11-11;0(0):101402.
    Species: Mouse
    Sample Types: Serum
  24. Low glycaemic diets alter lipid metabolism to influence tumour growth
    Authors: EC Lien, AM Westermark, Y Zhang, C Yuan, Z Li, AN Lau, KM Sapp, BM Wolpin, MG Vander Hei
    Nature, 2021-10-20;0(0):.
    Species: Human
    Sample Types: Plasma
  25. A Systems Approach Dissociates Fructose-Induced Liver Triglyceride from Hypertriglyceridemia and Hyperinsulinemia in Male Mice
    Authors: L Doridot, SA Hannou, SA Krawczyk, W Tong, MS Kim, GS McElroy, AJ Fowler, II Astapova, MA Herman
    Nutrients, 2021-10-18;13(10):.
    Species: Mouse
    Sample Types: Serum
  26. Litter expansion alters metabolic homeostasis in a sex specific manner
    Authors: K Kurup, SN Mann, J Jackson, S Matyi, M Ranjo-Bish, WM Freeman, MB Stout, A Richardson, A Unnikrishn
    PLoS ONE, 2021-09-29;16(9):e0237199.
    Species: Mouse
    Sample Types: Tissue Homogenate
  27. Effects of Combined Oxytocin and Beta-3 Receptor Agonist (CL 316243) Treatment on Body Weight and Adiposity in Male Diet-Induced Obese Rats
    Authors: MM Edwards, HK Nguyen, AD Dodson, AJ Herbertson, TA Wietecha, T Wolden-Han, JL Graham, MK Honeycutt, JD Slattery, KD O'Brien, PJ Havel, JE Blevins
    Frontiers in Physiology, 2021-09-08;12(0):725912.
    Species: Rat
    Sample Types: Plasma
  28. Dietary Essential Amino Acid Restriction Promotes Hyperdipsia via Hepatic FGF21
    Authors: PM Rusu, AY Chan, M Heikenwald, OJ Müller, AJ Rose
    Nutrients, 2021-04-26;13(5):.
    Species: Mouse
    Sample Types: Serum
  29. Rat Milk and Plasma Immunological Profile throughout Lactation
    Authors: B Grases-Pin, M Abril-Gil, P Torres-Cas, M Castell, MJ Rodríguez-, FJ Pérez-Cano, À Franch
    Nutrients, 2021-04-11;13(4):.
    Species: Rat
    Sample Types: Serum
  30. Ube2i deletion in adipocytes causes lipoatrophy in mice
    Authors: AR Cox, N Chernis, KH Kim, PM Masschelin, PK Saha, SM Briley, R Sharp, X Li, JB Felix, Z Sun, DD Moore, SA Pangas, SM Hartig
    Molecular Metabolism, 2021-03-24;0(0):101221.
    Species: Mouse
    Sample Types: Serum
  31. FoxO1 suppresses Fgf21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance
    Authors: O Stöhr, R Tao, J Miao, KD Copps, MF White
    Cell Reports, 2021-03-23;34(12):108893.
    Species: Mouse
    Sample Types: Serum
  32. Distinct roles of UVRAG and EGFR signaling in skeletal muscle homeostasis
    Authors: MJ Kim, D Febbraro, S Farkona, T Gillmore, JE Son, R Regeenes, HH Chang, E Pollock-Ta, J Yang, YJ Park, T Sivasubram, SJ Oh, P Saraon, I Stagljar, JV Rocheleau, CC Hui, I Caniggia, Z Hao, TW Mak, A Konvalinka, M Woo
    Molecular Metabolism, 2021-02-06;47(0):101185.
    Species: Mouse
    Sample Types: Serum
  33. Discordant hepatic fatty acid oxidation and triglyceride hydrolysis leads to liver disease
    Authors: ES Selen, J Choi, MJ Wolfgang
    JCI Insight, 2021-01-25;6(2):.
    Species: Transgenic Mouse
    Sample Types: Serum
  34. The Ubiquitin Ligase SIAH2 Negatively Regulates Glucocorticoid Receptor Activity and Abundance
    Authors: SJ Burke, JL Taylor, HM Batdorf, RC Noland, DH Burk, Y Yu, ZE Floyd, JJ Collier
    Biomedicines, 2020-12-30;9(1):.
    Species: Mouse
    Sample Types: Serum
  35. The Role of Stress and Genital Immunity in Sexual Trauma and HIV Susceptibility Among Adolescent Girls and Adult Women (The THRIVE Study): Protocol for a Longitudinal Case-Control Study
    Authors: JK Stockman, KM Anderson, MY Karris, CA Benson, K Tsuyuki, DA Granger, A Weber, M Ghosh
    JMIR research protocols, 2020-12-07;9(12):e18190.
    Species: Mouse
    Sample Types: Plasma
  36. Discovery of a novel fibroblast activation protein (FAP) inhibitor, BR103354, with anti-diabetic and anti-steatotic effects
    Authors: JM Cho, EH Yang, W Quan, EH Nam, HG Cheon
    Scientific Reports, 2020-12-04;10(1):21280.
    Species: Mouse
    Sample Types: Serum
  37. Enterohepatic transcription factor CREB3L3 protects atherosclerosis via SREBP competitive inhibition
    Authors: Y Nakagawa, Y Wang, SI Han, K Okuda, A Oishi, Y Yagishita, K Kumagai, H Ohno, Y Osaki, Y Mizunoe, M Araki, Y Murayama, H Iwasaki, M Konishi, N Itoh, T Matsuzaka, H Sone, N Yamada, H Shimano
    Cell Mol Gastroenterol Hepatol, 2020-11-24;0(0):.
    Species: Mouse
    Sample Types: Plasma
  38. Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease
    Authors: MF Yueh, F He, C Chen, C Vu, A Tripathi, R Knight, M Karin, S Chen, RH Tukey
    Proc Natl Acad Sci U S A, 2020-11-23;0(0):.
    Species: Mouse
    Sample Types: Serum
  39. Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution
    Authors: YW Yap, PM Rusu, AY Chan, BC Fam, A Jungmann, SM Solon-Biet, CK Barlow, DJ Creek, C Huang, RB Schittenhe, B Morgan, D Schmoll, B Kiens, MDW Piper, M Heikenwäld, SJ Simpson, S Bröer, S Andrikopou, OJ Müller, AJ Rose
    Nat Commun, 2020-06-09;11(1):2894.
    Species: Mouse
    Sample Types: Serum
  40. Targeted DNA demethylation of the Fgf21 promoter by CRISPR/dCas9-mediated epigenome editing
    Authors: N Hanzawa, K Hashimoto, X Yuan, K Kawahori, K Tsujimoto, M Hamaguchi, T Tanaka, Y Nagaoka, H Nishina, S Morita, I Hatada, T Yamada, Y Ogawa
    Sci Rep, 2020-03-20;10(1):5181.
    Species: Mouse
    Sample Types: Serum
  41. Sex-specific brain erythropoietin regulation of mouse metabolism and hypothalamic inflammation
    Authors: S Dey, Z Cui, O Gavrilova, X Zhang, M Gassmann, CT Noguchi
    JCI Insight, 2020-03-12;5(5):.
    Species: Mouse
    Sample Types: Serum
  42. A Genetic Model to Study the Contribution of Brown and Brite Adipocytes to Metabolism
    Authors: TD Challa, DH Dapito, E Kulenkampf, E Kiehlmann, C Moser, L Straub, W Sun, C Wolfrum
    Cell Rep, 2020-03-10;30(10):3424-3433.e4.
    Species: Mouse
    Sample Types: Serum
  43. PPAR&gamma and PPAR&alpha synergize to induce robust browning of white fat in�vivo
    Authors: T Kroon, M Harms, S Maurer, L Bonnet, I Alexanders, A Lindblom, A Ahnmark, D Nilsson, P Gennemark, G O'Mahony, V Osinski, C McNamara, J Boucher
    Mol Metab, 2020-02-18;36(0):100964.
    Species: Mouse
    Sample Types: Plasma
  44. Liver governs adipose remodelling via extracellular vesicles in response to lipid overload
    Authors: Y Zhao, MF Zhao, S Jiang, J Wu, J Liu, XW Yuan, D Shen, JZ Zhang, N Zhou, J He, L Fang, XT Sun, B Xue, CJ Li
    Nat Commun, 2020-02-05;11(1):719.
    Species: Mouse
    Sample Types: Plasma
  45. Therapeutic effect of dichloroacetate against atherosclerosis via hepatic FGF21 induction mediated by acute AMPK activation
    Authors: BK Min, CJ Oh, S Park, JM Lee, Y Go, BY Park, HJ Kang, DW Kim, JE Kim, EK Yoo, HE Kim, MJ Kim, YH Jeon, YH Kim, CH Lee, JH Jeon, IK Lee
    Exp. Mol. Med., 2019-09-30;51(10):114.
    Species: Mouse
    Sample Types: Serum
  46. Exploring the In�Vivo Role of the Mitochondrial Calcium Uniporter in Brown Fat Bioenergetics
    Authors: D Flicker, Y Sancak, E Mick, O Goldberger, VK Mootha
    Cell Rep, 2019-04-30;27(5):1364-1375.e5.
    Species: Mouse
    Sample Types: Plasma
  47. Transcriptional profiling of PPAR?-/- and CREB3L3-/- livers reveals disparate regulation of hepatoproliferative and metabolic functions of PPAR?
    Authors: PMM Ruppert, JG Park, X Xu, KY Hur, AH Lee, S Kersten
    BMC Genomics, 2019-03-11;20(1):199.
    Species: Mouse
    Sample Types: Plasma
  48. B-cell translocation gene 2 enhances fibroblast growth factor 21 production by inducing Kruppel-like factor 15
    Authors: YD Kim, SL Hwang, HJ Jeon, YH Jeon, B Nedumaran, K Kim, SE Lee
    Sci Rep, 2019-03-06;9(1):3730.
    Species: Mouse
    Sample Types: Serum
  49. Liver-derived fibroblast growth factor 21 mediates effects of glucagon-like peptide-1 in attenuating hepatic glucose output
    Authors: J Liu, K Yang, J Yang, W Xiao, Y Le, F Yu, L Gu, S Lang, Q Tian, T Jin, R Wei, T Hong
    EBioMedicine, 2019-03-01;0(0):.
    Species: Mouse
    Sample Types: Plasma
  50. Fibroblast growth factor 21 coordinates adiponectin to mediate the beneficial effects of low-protein diet on primordial follicle reserve
    Authors: Y Zhuo, L Hua, B Feng, X Jiang, J Li, D Jiang, X Huang, Y Zhu, Z Li, L Yan, C Jin, L Che, Z Fang, Y Lin, S Xu, J Li, Wu
    EBioMedicine, 2019-02-13;41(0):623-635.
    Species: Mouse
    Sample Types: Serum
  51. Repeated cold exposures protect a mouse model of Alzheimer's disease against cold-induced tau phosphorylation
    Authors: M Tournissac, P Bourassa, RD Martinez-C, TM Vu, SS Hébert, E Planel, F Calon
    Mol Metab, 2019-01-26;22(0):110-120.
    Species: Mouse
    Sample Types: Plasma
  52. Impact of aging and caloric restriction on fibroblast growth factor 21 signaling in rat white adipose tissue
    Authors: N Fujii, S Uta, M Kobayashi, T Sato, N Okita, Y Higami
    Exp. Gerontol., 2019-01-05;118(0):55-64.
    Species: Rat
    Sample Types: Plasma
  53. CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance
    Authors: SM Turpin-Nol, P Hammerschm, W Chen, A Jais, K Timper, M Awazawa, S Brodesser, JC Brüning
    Cell Rep, 2019-01-02;26(1):1-10.e7.
    Species: Mouse
    Sample Types: Serum
  54. A Wars2 Mutant Mouse Model Displays OXPHOS Deficiencies and Activation of Tissue-Specific Stress Response Pathways
    Authors: T Agnew, M Goldsworth, C Aguilar, A Morgan, M Simon, H Hilton, C Esapa, Y Wu, H Cater, L Bentley, C Scudamore, J Poulton, KJ Morten, K Thompson, L He, SDM Brown, RW Taylor, MR Bowl, RD Cox
    Cell Rep, 2018-12-18;25(12):3315-3328.e6.
    Species: Mouse
    Sample Types: Plasma
  55. Adipocyte OGT governs diet-induced hyperphagia and obesity
    Authors: MD Li, NB Vera, Y Yang, B Zhang, W Ni, E Ziso-Qejva, S Ding, K Zhang, R Yin, S Wang, X Zhou, EX Fang, T Xu, DM Erion, X Yang
    Nat Commun, 2018-11-30;9(1):5103.
    Species: Mouse
    Sample Types: Serum
  56. VCE-004.8, A Multitarget Cannabinoquinone, Attenuates Adipogenesis and Prevents Diet-Induced Obesity
    Authors: B Palomares, F Ruiz-Pino, C Navarrete, I Velasco, MA Sánchez-Ga, C Jimenez-Ji, C Pavicic, MJ Vazquez, G Appendino, ML Bellido, MA Calzado, M Tena-Sempe, E Muñoz
    Sci Rep, 2018-10-31;8(1):16092.
    Species: Mouse
    Sample Types: Serum
  57. Activin E Controls Energy Homeostasis in Both Brown and White Adipose Tissues as a Hepatokine
    Authors: O Hashimoto, M Funaba, K Sekiyama, S Doi, D Shindo, R Satoh, H Itoi, H Oiwa, M Morita, C Suzuki, M Sugiyama, N Yamakawa, H Takada, S Matsumura, K Inoue, S Oyadomari, H Sugino, A Kurisaki
    Cell Rep, 2018-10-30;25(5):1193-1203.
    Species: Mouse
    Sample Types: Serum
  58. FGF21 gene therapy as treatment for obesity and insulin resistance
    Authors: V Jimenez, C Jambrina, E Casana, V Sacristan, S Muñoz, S Darriba, J Rodó, C Mallol, M Garcia, X León, S Marcó, A Ribera, I Elias, A Casellas, I Grass, G Elias, T Ferré, S Motas, S Franckhaus, F Mulero, M Navarro, V Haurigot, J Ruberte, F Bosch
    EMBO Mol Med, 2018-08-01;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
  59. Curcumin supplementation mitigates NASH development and progression in female Wistar rats
    Authors: RP Cunningham, MP Moore, AN Moore, JC Healy, MD Roberts, RS Rector, JS Martin
    Physiol Rep, 2018-07-01;6(14):e13789.
    Species: Mouse
    Sample Types: Tissue Homogenates
  60. Retinoic Acid Increases Fatty Acid Oxidation and Irisin Expression in Skeletal Muscle Cells and Impacts Irisin In Vivo
    Authors: J Amengual, FJ García-Car, A Arreguín, H Mušinovi?, N Granados, A Palou, ML Bonet, J Ribot
    Cell. Physiol. Biochem., 2018-03-21;46(1):187-202.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  61. Deficiency of fibroblast growth factor 21 (FGF21) promotes hepatocellular carcinoma (HCC) in mice on a long term obesogenic diet
    Authors: G Singhal, G Kumar, S Chan, FM Fisher, Y Ma, HG Vardeh, IA Nasser, JS Flier, E Maratos-Fl
    Mol Metab, 2018-03-08;0(0):.
    Species: Mouse
    Sample Types: Serum
  62. Nrf2 prevents Notch-induced insulin resistance and tumorigenesis in mice
    Authors: DV Chartoumpe, Y Yagishita, M Fazzari, DL Palliyagur, UN Rao, A Zaravinos, NK Khoo, FJ Schopfer, KR Weiss, GK Michalopou, I Sipula, RM O'Doherty, TW Kensler, N Wakabayash
    JCI Insight, 2018-03-08;3(5):.
    Species: Mouse
    Sample Types: Plasma
  63. GSK3 is a negative regulator of the thermogenic program in brown adipocytes
    Authors: LK Markussen, S Winther, B Wicksteed, JB Hansen
    Sci Rep, 2018-02-22;8(1):3469.
    Species: Mouse
    Sample Types: Plasma
  64. Fibroblast growth factor-21 prevents diabetic cardiomyopathy via AMPK-mediated antioxidation and lipid-lowering effects in the heart
    Authors: H Yang, A Feng, S Lin, L Yu, X Lin, X Yan, X Lu, C Zhang
    Cell Death Dis, 2018-02-14;9(2):227.
    Species: Mouse
    Sample Types: Plasma
  65. Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood
    Authors: X Yuan, K Tsujimoto, K Hashimoto, K Kawahori, N Hanzawa, M Hamaguchi, T Seki, M Nawa, T Ehara, Y Kitamura, I Hatada, M Konishi, N Itoh, Y Nakagawa, H Shimano, T Takai-Igar, Y Kamei, Y Ogawa
    Nat Commun, 2018-02-12;9(1):636.
    Species: Mouse
    Sample Types: Serum
  66. Partial involvement of Nrf2 in skeletal muscle mitohormesis as an adaptive response to mitochondrial uncoupling
    Authors: V Coleman, P Sa-Nguanmo, J Koenig, TJ Schulz, T Grune, S Klaus, AP Kipp, M Ost
    Sci Rep, 2018-02-05;8(1):2446.
    Species: Mouse
    Sample Types: Plasma
  67. Perilipin 5 Deletion Unmasks an Endoplasmic Reticulum Stress - Fibroblast Growth Factor 21 Axis in Skeletal Muscle
    Authors: MK Montgomery, R Mokhtar, J Bayliss, HC Parkington, VM Suturin, CR Bruce, MJ Watt
    Diabetes, 2018-01-29;0(0):.
    Species: Mouse
    Sample Types: Plasma
  68. Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation
    Authors: RJ Perry, Y Wang, GW Cline, A Rabin-Cour, JD Song, S Dufour, XM Zhang, KF Petersen, GI Shulman
    Cell, 2018-01-04;172(1):234-248.e17.
    Species: Rat
    Sample Types: Plasma
  69. A PPAR Pan Agonist, MHY2013 Alleviates Age-Related Hepatic Lipid Accumulation by Promoting Fatty Acid Oxidation and Suppressing Inflammation
    Authors: HJ An, B Lee, SM Kim, DH Kim, KW Chung, SG Ha, KC Park, YJ Park, SJ Kim, HY Yun, P Chun, BP Yu, HR Moon, HY Chung
    Biol. Pharm. Bull., 2018-01-01;41(1):29-35.
    Species: Rat
    Sample Types: Serum
  70. The Role of Autophagy in Critical Illness-induced Liver Damage.
    Authors: Steven E Thiessen, Inge Derese, Sarah Derde, Thomas Dufour, Lies Pauwels, Youri Bekhuis, Isabel Pintelon, Wim Martinet, Greet Van Den B, Ilse Vanhorebe
    Scientific Reports, 2017-10-26;0(0):2045-2322.
    Species: Mouse
    Sample Types: Plasma
  71. Peripherally derived FGF21 promotes remyelination in the central nervous system
    Authors: M Kuroda, R Muramatsu, N Maedera, Y Koyama, M Hamaguchi, H Fujimura, M Yoshida, M Konishi, N Itoh, H Mochizuki, T Yamashita
    J. Clin. Invest., 2017-08-21;0(0):.
    Species: Mouse
    Sample Types: Serum
  72. Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury
    Authors: BN Desai, G Singhal, M Watanabe, D Stevanovic, T Lundasen, FM Fisher, ML Mather, HG Vardeh, N Douris, AC Adams, IA Nasser, GA FitzGerald, JS Flier, C Skarke, E Maratos-Fl
    Mol Metab, 2017-08-19;6(11):1395-1406.
    Species: Mouse
    Sample Types: Serum
  73. Lipophagy maintains energy homeostasis in the kidney proximal tubule during prolonged starvation
    Authors: S Minami, T Yamamoto, Y Takabatake, A Takahashi, T Namba, J Matsuda, T Kimura, JY Kaimori, I Matsui, T Hamano, H Takeda, M Takahashi, Y Izumi, T Bamba, T Matsusaka, F Niimura, Y Isaka
    Autophagy, 2017-08-16;0(0):0.
    Species: Mouse
    Sample Types: Plasma
  74. Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes
    Authors: SK Chang, AC Kohlgruber, F Mizoguchi, X Michelet, BJ Wolf, K Wei, PY Lee, L Lynch, D Duquette, V Ceperuelo-, AS Banks, MB Brenner
    J. Clin. Invest., 2017-07-31;0(0):.
    Species: Mouse
    Sample Types: Serum
  75. Loss of Hepatic Mitochondrial Long-Chain Fatty Acid Oxidation Confers Resistance to Diet-Induced Obesity and Glucose Intolerance
    Authors: J Lee, J Choi, ES Selen Alpe, L Zhao, T Hartung, S Scafidi, RC Riddle, MJ Wolfgang
    Cell Rep, 2017-07-18;20(3):655-667.
    Species: Mouse
    Sample Types: Serum
  76. Repletion of branched chain amino acids reverses mTORC1 signaling but not improved metabolism during dietary protein dilution
    Authors: A Maida, JSK Chan, KA Sjøberg, A Zota, D Schmoll, B Kiens, S Herzig, AJ Rose
    Mol Metab, 2017-06-24;6(8):873-881.
    Species: Mouse
    Sample Types: Serum
  77. Fgf21 regulates T-cell development in the neonatal and juvenile thymus
    Authors: Y Nakayama, Y Masuda, H Ohta, T Tanaka, M Washida, YI Nabeshima, A Miyake, N Itoh, M Konishi
    Sci Rep, 2017-03-23;7(1):330.
    Species: Mouse
    Sample Types: Serum
  78. Erythropoietin (EPO) ameliorates obesity and glucose homeostasis by promoting thermogenesis and endocrine function of classical brown adipose tissue (BAT) in diet-induced obese mice
    Authors: K Kodo, S Sugimoto, H Nakajima, J Mori, I Itoh, S Fukuhara, K Shigehara, T Nishikawa, K Kosaka, H Hosoi
    PLoS ONE, 2017-03-13;12(3):e0173661.
    Species: Mouse
    Sample Types: Plasma
  79. Loss of hepatic DEPTOR alters the metabolic transition to fasting
    Authors: A Caron, M Mouchiroud, N Gautier, SM Labbé, R Villot, L Turcotte, B Secco, G Lamoureux, M Shum, Y Gélinas, A Marette, D Richard, DM Sabatini, M Laplante
    Mol Metab, 2017-02-17;6(5):447-458.
    Species: Mouse
    Sample Types: Plasma
  80. CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPAR?
    Sci Rep, 2016-12-16;6(0):39182.
    Species: Mouse
    Sample Types: Plasma
  81. ?1-Adrenergic receptor downregulates hepatic FGF21 production and circulating FGF21 levels in mice
    Authors: Katsunori Nonogaki
    Neurosci. Lett, 2016-12-06;638(0):35-38.
    Species: Mouse
    Sample Types: Plasma
  82. Treatment with FGFR2-IIIc monoclonal antibody suppresses weight gain and adiposity in KKA(y) mice
    Authors: K Nonogaki
    Nutr Diabetes, 2016-11-28;6(11):e233.
    Species: Mouse
    Sample Types: Plasma
  83. mTORC1 is Required for Brown Adipose Tissue Recruitment and Metabolic Adaptation to Cold
    Sci Rep, 2016-11-23;6(0):37223.
    Species: Mouse
    Sample Types: Plasma
  84. Vildagliptin and caloric restriction for cardioprotection in pre-diabetic rats
    Authors: Nipon Chattipako
    J. Endocrinol., 2016-11-14;232(2):189-204.
    Species: Rat
    Sample Types: Plasma
  85. Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3? Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) ?
    Authors: David E Stec
    J. Biol. Chem., 2016-10-10;291(48):25179-25191.
    Species: Mouse
    Sample Types: Plasma
  86. Preserving of Postnatal Leptin Signaling in Obesity-Resistant Lou/C Rats following a Perinatal High-Fat Diet
    PLoS ONE, 2016-09-12;11(9):e0162517.
    Species: Rat
    Sample Types: Plasma
  87. The Orphan Nuclear Receptor ERR? Regulates Hepatic CB1 Receptor-Mediated Fibroblast Growth Factor 21 Gene Expression
    PLoS ONE, 2016-07-25;11(7):e0159425.
    Species: Mouse
    Sample Types: Serum
  88. Intramyocardial Adipose-Derived Stem Cell Transplantation Increases Pericardial Fat with Recovery of Myocardial Function after Acute Myocardial Infarction
    Authors: Jong-Ho Kim
    PLoS ONE, 2016-06-23;11(6):e0158067.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  89. Single ingestion of soy ?-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects
    Authors: Tsutomu Hashidume
    Sci Rep, 2016-06-17;6(0):28183.
    Species: Mouse
    Sample Types: Serum
  90. CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysis
    Authors: Jong-Gil Park
    Sci Rep, 2016-06-15;6(0):27938.
    Species: Mouse
    Sample Types: Plasma
  91. Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system
    Authors: Yoshimi Nakagawa
    Sci Rep, 2016-06-13;6(0):27857.
    Species: Mouse
    Sample Types: Plasma
  92. A muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling.
    Authors: Shimizu N, Maruyama T, Yoshikawa N, Matsumiya R, Ma Y, Ito N, Tasaka Y, Kuribara-Souta A, Miyata K, Oike Y, Berger S, Schutz G, Takeda S, Tanaka H
    Nat Commun, 2015-04-01;6(0):6693.
    Species: Mouse
    Sample Types: Plasma
  93. Hepatic mitogen-activated protein kinase phosphatase 1 selectively regulates glucose metabolism and energy homeostasis.
    Authors: Lawan A, Zhang L, Gatzke F, Min K, Jurczak M, Al-Mutairi M, Richter P, Camporez J, Couvillon A, Pesta D, Roth Flach R, Shulman G, Bennett A
    Mol Cell Biol, 2014-10-13;35(1):26-40.
    Species: Mouse
    Sample Types: Serum
  94. Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes.
    Authors: Lim, Yu-Mi, Lim, Hyejin, Hur, Kyu Yeon, Quan, Wenying, Lee, Hae-Youn, Cheon, Hwanju, Ryu, Dongryeo, Koo, Seung-Ho, Kim, Hong Lim, Kim, Jin, Komatsu, Masaaki, Lee, Myung-Sh
    Nat Commun, 2014-09-26;5(0):4934.
    Species: Mouse
    Sample Types: Serum
  95. Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes.
    Authors: Nakagawa Y, Satoh A, Yabe S, Furusawa M, Tokushige N, Tezuka H, Mikami M, Iwata W, Shingyouchi A, Matsuzaka T, Kiwata S, Fujimoto Y, Shimizu H, Danno H, Yamamoto T, Ishii K, Karasawa T, Takeuchi Y, Iwasaki H, Shimada M, Kawakami Y, Urayama O, Sone H, Takekoshi K, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Suzuki H, Yamada N, Shimano H
    Endocrinology, 2014-09-18;155(12):4706-19.
    Species: Mouse
    Sample Types: Plasma
  96. Long-term low carbohydrate diet leads to deleterious metabolic manifestations in diabetic mice.
    Authors: Handa K, Inukai K, Onuma H, Kudo A, Nakagawa F, Tsugawa K, Kitahara A, Moriya R, Takahashi K, Sumitani Y, Hosaka T, Kawakami H, Oyadomari S, Ishida H
    PLoS ONE, 2014-08-29;9(8):e104948.
    Species: Mouse
    Sample Types: Serum
  97. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on hormones of energy balance in a TCDD-sensitive and a TCDD-resistant rat strain.
    Authors: Linden J, Lensu S, Pohjanvirta R
    Int J Mol Sci, 2014-08-12;15(8):13938-66.
    Species: Rat
    Sample Types: Serum
  98. Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3.
    Authors: Khan N, Auranen M, Paetau I, Pirinen E, Euro L, Forsstrom S, Pasila L, Velagapudi V, Carroll C, Auwerx J, Suomalainen A
    EMBO Mol Med, 2014-06-01;6(6):721-31.
    Species: Mouse
    Sample Types: Serum
  99. Activation of AMPKalpha2 is not crucial for mitochondrial uncoupling-induced metabolic effects but required to maintain skeletal muscle integrity.
    Authors: Ost M, Werner F, Dokas J, Klaus S, Voigt A
    PLoS ONE, 2014-04-14;9(4):e94689.
    Species: Mouse
    Sample Types: Plasma
  100. Tissue-specific loss of DARS2 activates stress responses independently of respiratory chain deficiency in the heart.
    Authors: Dogan S, Pujol C, Maiti P, Kukat A, Wang S, Hermans S, Senft K, Wibom R, Rugarli E, Trifunovic A
    Cell Metab, 2014-03-04;19(3):458-69.
    Species: Mouse
    Sample Types: Serum
  101. Fibroblast growth factor 21 and thyroid hormone show mutual regulatory dependency but have independent actions in vivo.
    Authors: Domouzoglou, Eleni M, Fisher, Ffolliot, Astapova, Inna, Fox, Elliott, Kharitonenkov, Alexei, Flier, Jeffrey, Hollenberg, Anthony, Maratos-Flier, Elefther
    Endocrinology, 2014-02-24;155(5):2031-40.
    Species: Mouse
    Sample Types: Serum
  102. A serum component mediates food restriction-induced growth attenuation.
    Authors: Pando, Rakefet, Shtaif, Biana, Phillip, Moshe, Gat-Yablonski, Galia
    Endocrinology, 2014-01-23;155(3):932-40.
    Species: Rat
    Sample Types: Serum
  103. Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine.
    Authors: Keipert S, Ost M, Johann K, Imber F, Jastroch M, van Schothorst E, Keijer J, Klaus S
    Am J Physiol Endocrinol Metab, 2013-12-17;306(5):E469-82.
    Species: Mouse
    Sample Types: Plasma
  104. Retinoic acid receptor beta stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice.
    Authors: Li Y, Wong K, Walsh K, Gao B, Zang M
    J Biol Chem, 2013-02-19;288(15):10490-504.
    Species: Mouse
    Sample Types: Plasma
  105. Fasting-induced FGF21 is repressed by LXR activation via recruitment of an HDAC3 corepressor complex in mice.
    Authors: Archer A, Venteclef N, Mode A, Pedrelli M, Gabbi C, Clement K, Parini P, Gustafsson J, Korach-Andre M
    Mol Endocrinol, 2012-10-16;26(12):1980-90.
    Species: Mouse
    Sample Types: Serum
  106. Activation of the farnesoid x receptor induces hepatic expression and secretion of fibroblast growth factor 21.
    Authors: Cyphert HA, Ge X, Kohan AB, Salati LM, Zhang Y, Hillgartner FB
    J. Biol. Chem., 2012-06-01;287(30):25123-38.
    Species: Rat
    Sample Types: Plasma
  107. Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice.
    Authors: Ahlqvist KJ, Hamalainen RH, Yatsuga S, Uutela M, Terzioglu M, Gotz A, Forsstrom S, Salven P, Angers-Loustau A, Kopra OH, Tyynismaa H, Larsson NG, Wartiovaara K, Prolla T, Trifunovic A, Suomalainen A
    Cell Metab., 2012-01-04;15(1):100-9.
    Species: Mouse
    Sample Types: Serum
  108. Paradoxical regulation of human FGF21 by both fasting and feeding signals: is FGF21 a nutritional adaptation factor?
    Authors: Uebanso T, Taketani Y, Yamamoto H, Amo K, Ominami H, Arai H, Takei Y, Masuda M, Tanimura A, Harada N, Yamanaka-Okumura H, Takeda E
    PLoS ONE, 2011-08-01;6(8):e22976.
    Species: Human
    Sample Types: Cell Culture Supernates

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