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MS 4322

Catalog #: 8080 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8080/2
MS 4322 | CAS No. 2375432-47-4 | Active Degraders
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Description: Selective PRMT5 Degrader (PROTAC®)

Chemical Name: N-((S)-3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-((1-((S)-19-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidine-1-carbonyl)-20,20-dimethyl-17-oxo-3,6,9,12,15-pentaoxa-18-azahenicosanoyl)azetidin-3-yl)amino)pyrimidine-4-carboxamide

Purity: ≥98%

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Biological Activity

MS 4322 is a protein arginine methyltransferase 5 (PRMT5) Degrader (PROTAC®) (DC50 = 1.1 μM, Dmax = 74% in MCF-7 cells). Also inhibits PRMT5 methyltransferase activity (IC50 = 18 nM) and dose-dependently inhibits proliferation of HeLa, A549, A172 and Jurkat cancer cell lines. Comprises a PRMT5 inhibitor linked to an E3 ligase ligand.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
1101.33
Formula:
C55H76N10O12S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2375432-47-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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