MSOP

Biological Activity

MSOP is a selective group III metabotropic glutamate receptor antagonist. Displays an apparent K_D of 51 μM for the L-AP4-sensitive presynaptic mGluR on primary afferent terminals in spinal cord compared to > 700 μM for the (1S,3S)-ACPD-sensitive presynaptic mGlu in the same system. Has no activity on postsynaptic mGlu receptors or on ionotropic glutamate receptors on neonatal rat motoneurons.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
   Tollefson and Taylor
   CNS Drug Reviews, 2000;6:303
2. Phosphono substituted amino acids as selective metabotropic glutamate receptor antagonists.
   Jane et al.
   Phosphorous, Sulphur and Silicon, 1996;109-110:313
3. α-Methyl derivatives of serine-O-phosphate as novel, selective competitive metabotropic glutamate receptor antagonists.
   Thomas et al.
   Neuropharmacology, 1996;35:637
4. Serine-O-phosphate derivatives as novel, potent and selective metabotropic glutamate receptor (mGluR) antagonists.
   Thomas et al.
   Soc.Neurosci.Abstr., 1995;21:P616

Product Datasheets