Home / Casein Kinase 1 Inhibitors / MU 1742

MU 1742

Catalog #: 7979 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7979/2
MU 1742 | Casein Kinase 1 Inhibitors
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Description: Potent and selective CK1α, CK1δ and CK1ε inhibitor

Chemical Name: 4-(1-((4-Fluoro-1-methylpiperidin-4-yl)methyl)-4-(5-fluoropyridin-2-yl)-1H-imidazol-5-yl)-1H-pyrrolo[2,3-b]pyridine

Purity: ≥98%

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Biological Activity

MU 1742 is a potent and selective casein kinase 1α (CK1α), CK1δ and CK1ε inhibitor (IC50 values are 6, 7 and 28 nM for CK1δ, CK1α and CK1ε respectively). In vivo, MU 1742 inhibits CK1δ/ε-dependent DVL3 phosphorylation in mouse lung tissue. MU 1742 is orally bioavailable.

Technical Data

M.Wt:
408.46
Formula:
C22H22F2N6
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MU 1742 probe summary on the SGC website.

Product Datasheets

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