NAN-190 hydrobromide

Catalog #: 0553
3 Citations Datasheet / COA / SDS

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NAN-190 hydrobromide | CAS No. 115338-32-4 | 5-HT1A Receptor Antagonists

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Description: 5-HT1A antagonist

Chemical Name: 1-(2-Methoxyphenyl)-4-(4-phthalimidobutyl)piperazine hydrobromide

Purity: ≥98%

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Product Details

Citations (3)

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Biological Activity

NAN-190 hydrobromide is a 5-HT_1A antagonist.

Technical Data

M.Wt:

474.4

Formula:

C₂₃H₂₇N₃O₃.HBr

Solubility:

Soluble to 10 mM in DMSO

Purity:

≥98%

Storage:

Store at RT

CAS No:

115338-32-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Effects of the putative 5-HT_1A receptor antagonist NAN-190 on free feeding and on feeding induced by the 5-HT_1A receptor agonist 8-OH-DPAT in the rat.
Douris
Eur.J.Pharmacol., 1992;219:105
Arylpiperazine derivatives as high affinity 5-HT_1A serotonin ligands.
Glennon et al.
J.Med.Chem., 1988;31:1968
NAN-190: an arylpiperazine analog that antagonizes the stimulus effects of the 5-HT_1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT).
Williams and Glennon
Eur.J.Pharmacol., 1988;154:339

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Citations for NAN-190 hydrobromide

The citations listed below are publications that use Tocris products. Selected citations for NAN-190 hydrobromide include:

3 Citations: Showing 1 - 3

Activity-dependent expression of Lmx1b regulates specification of serotonergic neurons modulating swimming behavior.
Authors: Demarque and
Neuron 2010;67:321
Gαo/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways.
Authors: Pagano Et al.
Physiol Behav 2008;20:1190
Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery.
Authors: Geerts Et al.
Br J Pharmacol 1999;127:1327

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