NBQX

Catalog # Availability Size / Price Qty
0373/10
0373/50
NBQX | CAS No. 118876-58-7 | AMPA Receptor Antagonists
1 Image
Description: Potent AMPA antagonist; more selective than CNQX (Cat. No. 0190)

Chemical Name: 2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide

Purity: ≥98%

Product Details
Citations (180)
Supplemental Products
Reviews

Biological Activity

NBQX is a selective and competitive AMPA and kainate receptor antagonist (IC50 = 0.15 μM and 4.8 μM, respectively). NBQX blocks the antidepressant effects of 8-Hydroxy-DPAT hydrobromide (Cat. No. 0529), decreases mTOR and BDNF levels. NBQX is neuroprotective, anticonvulsant, antinociceptive and active in vivo.

NBQX disodium salt, a more water-soluble form of NBQX, also available.

Technical Data

M.Wt:
336.28
Formula:
C12H8N4O6S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
118876-58-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Novo Nordisk A/S
Other Product-Specific Information:

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. Expression of cocaine-evoked synaptic plasticity by GluN3A-containing NMDA receptors.
    Yuan T, Mameli M, O' Connor E, Dey P, Verpelli C, Sala C, Perez-Otano I, Luscher C, Bellone C
    Neuron, 2013;80(4):1025-38.
  3. Re-silencing of silent synapses unmasks anti-relapse effects of environmental enrichment
    YY Ma, X Wang, Y Huang, H Marie, EJ Nestler, OM Schlüter, Y Dong
    Proc Natl Acad Sci USA, 2016;0(0):.
  4. Intersectin 1 is a component of the Reelin pathway to regulate neuronal migration and synaptic plasticity in the hippocampus
    B Jakob, G Kochlamaza, M Jäpel, A Gauhar, HH Bock, T Maritzen, V Haucke
    Proc. Natl. Acad. Sci. U.S.A., 2017;114(21):5533-5538.
  5. The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline (NBQX) in a rat focal ischaemia model.
    Gill et al.
    Brain Res., 1992;580:35
  6. Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy.
    Namba et al.
    Brain Res., 1994;638:36
  7. The pharmacology of AMPA receptors and their antagonists.
    Sheardown et al.
    Stroke, 1993;24:146
  8. Pharmacological characterization of non-NMDA subtypes of glutamate receptors in the neonatal rat hemisected spinal cord in vitro.
    Zeman and Lodg
    Br.J.Pharmacol., 1992;106:367

Product Datasheets

Or select another batch:
View Batch
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for NBQX

The citations listed below are publications that use Tocris products. Selected citations for NBQX include:

180 Citations: Showing 1 - 10

  1. Pharmacological analysis of ionotropic glutamate receptor function in neuronal circuits of the zebrafish olfactory bulb.
    Authors: Tabor and Friedrich
    PLoS One  ;3:e1416
  2. Voltage-gated potassium channels ensure action potential shape fidelity in distal axons.
    Authors: Sabater Et al.
    J Neurosci  2021;41:5372
  3. Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner
    Authors: Dorst Et al.
    Nat Comms  2020;11:5113
  4. Homeostatic Intrinsic Plasticity Is Functionally Altered in Fmr1 KO Cortical Neurons.
    Authors: Bülow Et al.
    Cell Rep  2019;26:1378
  5. Kilohertz frame-rate two-photon tomography.
    Authors: Kazemipour Et al.
    Nature Methods  2019;16:778
  6. Simultaneous voltage and calcium imaging and optogenetic stimulation with high sensitivity and a wide field of view.
    Authors: Nguyen Et al.
    Biomed Opt Express  2019;10:789
  7. AMP-Activated Protein Kinase Is Essential for the Maintenance of Energy Levels during Synaptic Activation.
    Authors: Marinangeli Et al.
    iScience  2018;9:1
  8. Drd3 Signaling in the Lateral Septum Mediates Early Life Stress-Induced Social Dysfunction.
    Authors: Shin Et al.
    Neuron  2018;97:195
  9. Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin.
    Authors: Matsui and Alvarez Et al.
    Cell Rep  2018;23(13):3852
  10. DA D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice.
    Authors: Guo
    Aging Cell  2017;16(6):1323
  11. Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism.
    Authors: Wang Et al.
    J Clin Invest  2017;127:1978
  12. Using c-kit to genetically target cerebellar molecular layer interneurons in adult mice.
    Authors: Amat
    PLoS One  2017;12(6):e0179347
  13. Toll-like receptor 4 deficiency alters nucleus accumbens synaptic physiology and drug reward behavior.
    Authors: Kashima and Grueter
    Proc Natl Acad Sci U S A.  2017;114(33):8865
  14. Presynaptic GABAB receptors reduce transmission at parabrachial synapses in the lateral central amygdala by inhibiting N-type calcium channels.
    Authors: Delaney and Crane
    Sci Rep  2016;6:19255
  15. Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus.
    Authors: Dennis Et al.
    J Neurosci  2016;26:414
  16. NE Modulates Pyramidal Cell Synaptic Properties in the Anterior Piriform Cortex of Mice: Age-Dependent Effects of β-adrenoceptors.
    Authors: Ghosh Et al.
    Proc Natl Acad Sci U S A  2015;9:450
  17. AMPA Receptor-mTOR Activation is Required for the Antidepressant-Like Effects of Sarcosine during the Forced Swim Test in Rats: Insertion of AMPA Receptor may Play a Role.
    Authors: Chen Et al.
    Front Behav Neurosci  2015;9:162
  18. Calcium current homeostasis and synaptic deficits in hippocampal neurons from Kelch-like 1 knockout mice.
    Authors: Perissinotti Et al.
    Elife  2015;8:444
  19. Co-release of glutamate and GABA from single vesicles in GABAergic neurons exogenously expressing VGLUT3.
    Authors: Zimmermann Et al.
    J Neurosci  2015;7:16
  20. Optical control of NMDA receptors with a diffusible photoswitch.
    Authors: Laprell Et al.
    Front Cell Neurosci  2015;6:8076
  21. R-KA: a rapid-onset and sustained antidepressant without psychotomimetic side effects.
    Authors: Yang Et al.
    Transl Psychiatry  2015;5:e632
  22. The Chemokine MIP-1α/CCL3 impairs mouse hippocampal synaptic transmission, plasticity and memory.
    Authors: Marciniak Et al.
    Front Synaptic Neurosci  2015;5:15862
  23. Corelease of acetylcholine and GABA from cholinergic forebrain neurons.
    Authors: Saunders Et al.
    Cereb Cortex  2015;4
  24. A simple retinal mechanism contributes to perceptual interactions between rod- and cone-mediated responses in primates.
    Authors: Grimes Et al.
    Elife  2015;4
  25. Involvement of adrenoceptors, DA receptors and AMPA receptors in antidepressant-like action of 7-O-ethylfangchinoline in mice.
    Authors: Sheng Et al.
    Acta Pharmacol Sin  2015;36:949
  26. BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells.
    Authors: Hirono Et al.
    Brain Res  2015;35:7082
  27. Activation of corticostriatal circuitry relieves chronic neuropathic pain.
    Authors: Lee Et al.
    Physiol Rep  2015;35:5247
  28. Dual-channel circuit mapping reveals sensorimotor convergence in the primary motor cortex.
    Authors: Hooks Et al.
    Front Cell Neurosci  2015;35:4418
  29. Loss of Local Astrocyte Support Disrupts Action Potential Propagation and Glutamate Release Synchrony from Unmyelinated Hippocampal Axon Terminals In Vitro.
    Authors: Sobieski Et al.
    PLoS One  2015;35:11105
  30. Afterhyperpolarization (AHP) regulates the frequency and timing of action potentials in the mitral cells of the olfactory bulb: role of olfactory experience.
    Authors: Duménieu Et al.
    Sci Rep  2015;3
  31. Impact of subanesthetic doses of KA on AMPA-mediated responses in rats: An in vivo electrophysiological study on monoaminergic and glutamatergic neurons.
    Authors: Iskandrani Et al.
    Stroke  2015;29:792
  32. Functional α7 nicotinic receptors are expressed on immature granule cells of the postnatal dentate gyrus.
    Authors: John Et al.
    J Neurosci  2015;1601:15
  33. Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture.
    Authors: Pasca Et al.
    Front Cell Neurosci  2015;12:671
  34. Tectal microcircuit generating visual selection commands on gaze-controlling neurons.
    Authors: Kardamakis Et al.
    J Neurosci  2015;112:E1956
  35. The effect of Dflu. on neuronal communication at a central synapse.
    Authors: Mapelli Et al.
    Nat Commun  2015;10:e0123534
  36. HSF1 transcriptional activity mediates alcohol induction of Vamp2 expression and GABA release.
    Authors: Varodayan and Harrison
    J Neurosci  2014;7:89
  37. Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA.
    Authors: Suzuki Et al.
    Nat Commun  2014;5:4153
  38. Cross-synaptic synchrony and transmission of signal and noise across the mouse retina.
    Authors: Grimes Et al.
    Elife  2014;3:e03892
  39. Fast retrieval and autonomous regulation of single spontaneously recycling synaptic vesicles.
    Authors: Leitz and Kavalali
    Elife  2014;3:e03658
  40. Repeated binge-like ethanol drinking alters ethanol drinking patterns and depresses striatal GABAergic transmission.
    Authors: Wilcox Et al.
    Neuropsychopharmacology  2014;39:579
  41. L-type Ca2+ currents at CA1 synapses, but not CA3 or dentate granule neuron synapses, are increased in 3xTgAD mice in an age-dependent manner.
    Authors: Wang and Mattson
    Neurobiol Aging  2014;35:88
  42. Glycolysis and oxidative phosphorylation in neurons and astrocytes during network activity in hippocampal slices.
    Authors: Ivanov Et al.
    J Cereb Blood Flow Metab  2014;34:397
  43. A novel mechanism for nicotinic potentiation of glutamatergic synapses.
    Authors: Halff Et al.
    J Neurosci  2014;34:2051
  44. Modulation of neuronal microcircuit activities within the medial prefrontal cortex by mGluR5 positive allosteric modulator.
    Authors: Pollard Et al.
    J Psychopharmacol  2014;28:935
  45. Rac1 and rac3 GTPases control synergistically the development of cortical and hippocampal GABAergic interneurons.
    Authors: Vaghi Et al.
    Cereb Cortex  2014;24:1247
  46. CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses.
    Authors: Bemben Et al.
    Nat Neurosci  2014;17:56
  47. hPSC-derived maturing GABAergic interneurons ameliorate seizures and abnormal behavior in epileptic mice.
    Authors: Cunningham Et al.
    Cell Stem Cell  2014;15:559
  48. Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 δ glutamate receptors.
    Authors: Ady Et al.
    Proc Natl Acad Sci U S A  2014;15:103
  49. Depressed GABA and glutamate synaptic signaling by 5-HT1A receptors in the nucleus tractus solitarii and their role in cardiorespiratory function.
    Authors: Ostrowski Et al.
    J Neurophysiol  2014;111:2493
  50. Synaptic NMDA receptor-dependent Ca2+ entry drives membrane potential and Ca2+ oscillations in spinal ventral horn neurons.
    Authors: Alpert and
    PLoS One  2013;8:e63154
  51. Contribution of NMDA receptor hypofunction in prefrontal and cortical excitatory neurons to schizophrenia-like phenotypes.
    Authors: Rompala Et al.
    J Neurosci  2013;8:e61278
  52. Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors.
    Authors: Rojas Et al.
    Mol Pharmacol  2013;83:106
  53. Different transporter systems regulate extracellular GABA from vesicular and non-vesicular sources.
    Authors: Song Et al.
    Front Cell Neurosci  2013;7:23
  54. Intersecting circuits generate precisely patterned retinal waves.
    Authors: Akrouh and Kerschensteiner
    Neuron  2013;79:322
  55. Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS.
    Authors: Koeglsperger Et al.
    Glia  2013;61:985
  56. Protein tyrosine phosphatase α in the dorsomedial striatum promotes excessive ethanol-drinking behaviors.
    Authors: Hamida Et al.
    Nat Neurosci  2013;33:14369
  57. Moderate prenatal alcohol exposure reduces plasticity and alters NMDA receptor subunit composition in the dentate gyrus.
    Authors: Brady Et al.
    Proc Natl Acad Sci U S A  2013;33:1062
  58. Activity-regulated somatostatin expression reduces dendritic spine density and lowers excitatory synaptic transmission via postsynaptic somatostatin receptor 4.
    Authors: Hou and Yu
    J Biol Chem  2013;288:2501
  59. Behavioural and functional characterization of Kv10.1 (Eag1) knockout mice.
    Authors: Ufartes Et al.
    Hum Mol Genet  2013;22:2247
  60. The adhesion protein IgSF9b is coupled to neuroligin 2 via S-SCAM to promote inhibitory synapse development.
    Authors: Woo Et al.
    J Cell Biol  2013;201:929
  61. Genetic markers of a Munc13 protein family member, BAIAP3, are gender specifically associated with anxiety and benzodiazepine abuse in mice and humans.
    Authors: Wojcik Et al.
    Mol Med  2013;19:135
  62. Physiological release of endogenous tau is stimulated by neuronal activity.
    Authors: Pooler Et al.
    J Neuroimmunol  2013;14:389
  63. Neural progenitors organize in small-world networks to promote cell proliferation.
    Authors: Malmersjö Et al.
    J Neurosci  2013;110:E1524
  64. S-nitrosylation of AMPA receptor GluA1 regulates phosphorylation, single-channel conductance, and endocytosis.
    Authors: Selvakumar Et al.
    Proc Natl Acad Sci U S A  2013;110:1077
  65. AMPA/kainate glutamate receptors contribute to inflammation, degeneration and pain related behaviour in inflammatory stages of arthritis.
    Authors: Bonnet Et al.
    Ann Rheum Dis  2013;
  66. Axon-glia synapses are highly vulnerable to white matter injury in the developing brain.
    Authors: Shen Et al.
    J Neurosci Res  2012;90:105
  67. Differential requirement for protein synthesis in presynaptic unmuting and muting in hippocampal glutamate terminals.
    Authors: Crawford Et al.
    PLoS One  2012;7:e51930
  68. Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability.
    Authors: Klug Et al.
    PLoS One  2012;7:e45323
  69. Olfactory bulb glomerular NMDA receptors mediate olfactory nerve potentiation and odor preference learning in the neonate rat.
    Authors: Lethbridge Et al.
    J Neurosci  2012;7:e35024
  70. Consolidation of remote fear memories involves Corticotropin-Releasing Hormone (CRH) receptor type 1-mediated enhancement of AMPA receptor GluR1 signaling in the dentate gyrus.
    Authors: Thoeringer Et al.
    J Neuroimmunol  2012;37:787
  71. β-OE unmasks metabotropic receptor-mediated metaplasticity of NMDA receptor transmission in the female rat dentate gyrus.
    Authors: Nebieridze Et al.
    Psychoneuroendocrinology  2012;37:1845
  72. The role of inhibition in oscillatory wave dynamics in the cortex.
    Authors: Xiao Et al.
    Eur J Neurosci  2012;36:2201
  73. Mixed electrical-chemical transmission between hippocampal mossy fibers and pyramidal cells.
    Authors: Vivar Et al.
    Eur J Neurosci  2012;35:76
  74. Presynaptic Cav3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons.
    Authors: Jacus Et al.
    Proc Natl Acad Sci U S A  2012;32:9374
  75. Alteration of synaptic network dynamics by the intellectual disability protein PAK3.
    Authors: Dubos Et al.
    Eur J Neurosci  2012;32:519
  76. Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals.
    Authors: Cassé Et al.
    J Neurosci  2012;32:5186
  77. Endocannabinoid-mediated long-term depression of afferent excitatory synapses in hippocampal pyramidal cells and GABAergic interneurons.
    Authors: Peterfi Et al.
    J Neurosci  2012;32:14448
  78. Lack of kinase regulation of canonical transient receptor potential 3 (TRPC3) channel-dependent currents in cerebellar Purkinje cells.
    Authors: Nelson and Glitsch
    PLoS One  2012;287:6326
  79. Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala.
    Authors: Daftary Et al.
    Neuroscience  2012;224:125
  80. Heterogeneous reallocation of presynaptic efficacy in recurrent excitatory circuits adapting to inactivity.
    Authors: Mitra Et al.
    Nat Neurosci  2012;15:250
  81. Focal adhesion kinase regulates actin nucleation and neuronal filopodia formation during axonal growth.
    Authors: Chacón Et al.
    Dev Neurobiol  2012;139:3200
  82. Effect of prolonged R.zole exposure on cultured motoneurons in a mouse model of ALS.
    Authors: Schuster Et al.
    J Neurophysiol  2012;107:484
  83. Development of NMDA NR2 subunits and their roles in critical period maturation of neocortical GABAergic interneurons.
    Authors: Zhang and Sun
    Neuropsychopharmacology  2011;71:221
  84. CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton.
    Authors: Roselli Et al.
    PLoS One  2011;6:e23097
  85. Synaptic responses evoked by tactile stimuli in Purkinje cells in mouse cerebellar cortex Crus II in vivo.
    Authors: Chu Et al.
    PLoS One  2011;6:e22752
  86. Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum.
    Authors: Higley Et al.
    PLoS One  2011;6:e19155
  87. Sleep-deprivation regulates α-2 adrenergic responses of rat hypocretin/orexin neurons.
    Authors: Uschakov Et al.
    PLoS One  2011;6:e16672
  88. Cannabinoids attenuate hippocampal γ oscillations by suppressing excitatory synaptic input onto CA3 pyramidal neurons and fast spiking basket cells.
    Authors: Holderith Et al.
    Eur J Neurosci  2011;589:4921
  89. Calcium-independent inhibitory G-protein signaling induces persistent presynaptic muting of hippocampal synapses.
    Authors: Crawford Et al.
    Proc Natl Acad Sci U S A  2011;31:979
  90. NMDA receptor signaling in oligodendrocyte progenitors is not required for oligodendrogenesis and myelination.
    Authors: Biase Et al.
    J Neurophysiol  2011;31:12650
  91. An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus.
    Authors: Etherton Et al.
    EMBO J  2011;30:2908
  92. Quantal amplitude at the cone ribbon synapse can be adjusted by changes in cytosolic glutamate.
    Authors: Bartoletti and Thoreson
    Mol Vis  2011;17:920
  93. Developmental maturation of excitation and inhibition balance in principal neurons across four layers of somatosensory cortex.
    Authors: Zhang Et al.
    J Neurosci  2011;174:45931
  94. Inflammation alters trafficking of extrasynaptic AMPA receptors in tonically firing lamina II neurons of the rat spinal dorsal horn.
    Authors: Kopach Et al.
    Pain  2011;152:912
  95. Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1.
    Authors: Straub Et al.
    Nat Neurosci  2011;14:866
  96. Ca(2+)-dependent enhancement of release by subthreshold somatic depolarization.
    Authors: Christie Et al.
    Nat Neurosci  2011;14:62
  97. The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells.
    Authors: Abe Et al.
    Neuroscience  2011;108:12497
  98. Endogenous N-acetylaspartylglutamate (NAAG) inhibits synaptic plasticity/transmission in the amygdala in a mouse inflammatory pain model.
    Authors: Adedoyin Et al.
    Mol Pain  2010;6:60
  99. Nociceptive stimulation induces expression of Arc/Arg3.1 in the spinal cord with a preference for neurons containing enkephalin.
    Authors: Hossaini Et al.
    Proc Natl Acad Sci U S A  2010;6:43
  100. Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels.
    Authors: Buchanan Et al.
    Neuron  2010;68:948
  101. Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase.
    Authors: Jackson Et al.
    PLoS One  2010;5:e11962
  102. High-Pass Filtering and Dynamic Gain Regulation Enhance Vertical Bursts Transmission along the Mossy Fiber Pathway of Cerebellum.
    Authors: Mapelli Et al.
    Proc Natl Acad Sci U S A  2010;4:14
  103. Selected SALM (synaptic adhesion-like molecule) family proteins regulate synapse formation.
    Authors: Mah Et al.
    J Physiol  2010;30:5559
  104. Different relationship of N- and P/Q-type Ca2+ channels to channel-interacting slots in controlling neurotransmission at cultured hippocampal synapses.
    Authors: Cao and Tsien
    J Neurosci  2010;30:4536
  105. Excitability and synaptic communication within the oligodendrocyte lineage.
    Authors: Biase Et al.
    J Neurosci  2010;30:3600
  106. Calcium binding to PICK1 is essential for the intracellular retention of AMPA receptors underlying long-term depression.
    Authors: Citri Et al.
    J Neurosci  2010;30:16437
  107. Postsynaptic spiking homeostatically induces cell-autonomous regulation of inhibitory inputs via retrograde signaling.
    Authors: Peng Et al.
    J Neurosci  2010;30:16220
  108. Rapid activation of dormant presynaptic terminals by phorbol esters.
    Authors: Chang Et al.
    J Neurosci  2010;30:10048
  109. Contribution of the d-Serine-Dependent Pathway to the Cellular Mechanisms Underlying Cognitive Aging.
    Authors: Potier Et al.
    Front Aging Neurosci  2010;2:1
  110. Activation of native TRPC3 cation channels by phospholipase D.
    Authors: Glitsch
    FASEB J  2010;24:318
  111. Effect of hypoxia on expiratory muscle activity in fetal sheep.
    Authors: Bissonnette Et al.
    Respir Physiol Neurobiol  2010;171:110
  112. Competitive regulation of synaptic Ca2+ influx by D2 DA and A2A adenosine receptors.
    Authors: Higley and Sabatini
    Nat Neurosci  2010;13:958
  113. A dynamic role for GABA receptors on the firing pattern of midbrain DArgic neurons.
    Authors: Lobb Et al.
    J Neurophysiol  2010;104:403
  114. Dynamic modulation of phasic and asynchronous glutamate release in hippocampal synapses.
    Authors: Chang
    J Neurophysiol  2010;103:392
  115. Combinatorial responses controlled by synaptic inhibition in the cerebellum granular layer.
    Authors: Mapelli Et al.
    Neuropharmacology  2010;103:250
  116. Characterization of engineered channelrhodopsin variants with improved properties and kinetics.
    Authors: Lin Et al.
    Biophys J  2009;96:1803
  117. Enhanced excitatory transmission at cortical synapses as the basis for facilitated spreading depression in Ca(v)2.1 knockin migraine mice.
    Authors: Tottene Et al.
    Neuron  2009;61:762
  118. ATP-dependent infra-slow (0.1 Hz) oscillations in thalamic networks.
    Authors: Lörincz Et al.
    PLoS One  2009;4:e4447
  119. Specific synapses develop preferentially among sister excitatory neurons in the neocortex.
    Authors: Yu Et al.
    EMBO Rep  2009;458:501
  120. NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: role of the ventral tegmental area and central nucleus of the amygdala.
    Authors: Kenny Et al.
    Neuropsychopharmacology  2009;34:266
  121. N-MthD.-aspartate receptor- and metabotropic glutamate receptor-dependent long-term depression are differentially regulated by the ubiquitin-proteasome system.
    Authors: Citri Et al.
    J Neurophysiol  2009;30:1443
  122. D1/D5 modulation of synaptic NMDA receptor currents.
    Authors: Varela Et al.
    J Neurosci  2009;29:3109
  123. Millisecond timescale disinhibition mediates fast information transmission through an avian basal ganglia loop.
    Authors: Leblois Et al.
    J Neurosci  2009;29:15420
  124. Chronic CXCL10 alters neuronal properties in rat hippocampal culture.
    Authors: Cho Et al.
    J Neurosci  2009;207:92
  125. AMPA receptor trafficking and synaptic plasticity require SQSTM1/p62.
    Authors: Jiang Et al.
    Hippocampus  2009;19:392
  126. Tamoxifen mediated estrogen receptor activation protects against early impairment of hippocampal neuron excitability in an oxygen/glucose deprivation brain slice ischemia model.
    Authors: Zhang Et al.
    Brain Res  2009;1247:196
  127. Experience-dependent intrinsic plasticity in interneurons of barrel cortex layer IV.
    Authors: Sun
    J Neurosci  2009;102:2955
  128. Co-transmission of DA and GABA in periglomerular cells.
    Authors: Maher and Westbrook
    J Neurophysiol  2008;99:1559
  129. GABA actions in hippocampal area CA3 during postnatal development: differential shift from depolarizing to hyperpolarizing in somatic and dendritic compartments.
    Authors: Romo-Parra Et al.
    J Neurosci  2008;99:1523
  130. Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation.
    Authors: Kim and Tsien
    Neuron  2008;58:925
  131. Involvement of AMPA receptors in the antidepressant-like effects of Li in the mouse tail suspension test and forced swim test.
    Authors: Gould Et al.
    Neuropharmacology  2008;54:577
  132. Cholecystokinin inhibits endocannabinoid-sensitive hippocampal IPSPs and stimulates others.
    Authors: Karson Et al.
    J Biol Chem  2008;54:117
  133. Apoptosis induced by domoic acid in mouse cerebellar granule neurons involves activation of p38 and JNK MAP kinases.
    Authors: Giordano Et al.
    J Physiol  2008;52:1100
  134. Cortical adenylyl cyclase 1 is required for thalamocortical synapse maturation and aspects of layer IV barrel development.
    Authors: Iwasato Et al.
    J Neurosci  2008;28:5931
  135. Competition between calcium-activated K+ channels determines cholinergic action on firing properties of basolateral amygdala projection neurons.
    Authors: Power and Sah
    J Neurosci  2008;28:3209
  136. White matter vulnerability to ischemic injury increases with age because of enhanced excitotoxicity.
    Authors: Baltan Et al.
    J Neurosci  2008;28:1479
  137. Resveratrol attenuates early pyramidal neuron excitability impairment and death in acute rat hippocampal slices caused by oxygen-glucose deprivation.
    Authors: Zhang Et al.
    Exp Neurol  2008;212:44
  138. The chemokine CCL2 activates p38 mitogen-activated protein kinase pathway in cultured rat hippocampal cells.
    Authors: Cho and Gruol
    J Neurosci  2008;199:94
  139. Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells.
    Authors: Shin Et al.
    Nature  2008;105:746
  140. Long-lasting NMDA receptor-mediated EPSCs in mouse striatal medium spiny neurons.
    Authors: Logan Et al.
    J Neurophysiol  2007;98:2693
  141. Increased thalamocortical synaptic response and decreased layer IV innervation in GAP-43 knockout mice.
    Authors: Albright Et al.
    J Neurophysiol  2007;98:1610
  142. Endogenous D-serine contributes to NMDA-receptor-mediated light-evoked responses in the vertebrate retina.
    Authors: Gustafson Et al.
    J Neurophysiol  2007;98:122
  143. Presynaptic plasma membrane Ca2+ ATPase isoform 2a regulates excitatory synaptic transmission in rat hippocampal CA3.
    Authors: Jensen Et al.
    Chem Senses  2007;579:85
  144. Long-term modifications in the strength of excitatory associative inputs in the piriform cortex.
    Authors: Young and Sun
    Proc Natl Acad Sci U S A  2007;32:783
  145. Axon and dendrite geography predict the specificity of synaptic connections in a functioning spinal cord network.
    Authors: Li Et al.
    Neural Dev  2007;2:17
  146. Plasma membrane Ca2+ ATPase 2 contributes to short-term synapse plasticity at the parallel fiber to Purkinje neuron synapse.
    Authors: Empson Et al.
    Proc Natl Acad Sci U S A  2007;27:3753
  147. Disynaptic amplification of metabotropic glutamate receptor 1 responses in the olfactory bulb.
    Authors: Jan and Westbrook
    J Neurosci  2007;27:132
  148. Somatodendritic release of glutamate regulates synaptic inhibition in cerebellar Purkinje cells via autocrine mGluR1 activation.
    Authors: Duguid Et al.
    J Neurosci  2007;27:12464
  149. Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices.
    Authors: Fukunaga Et al.
    Br J Pharmacol  2007;151:870
  150. Vesicular release of glutamate from unmyelinated axons in white matter.
    Authors: Ziskin Et al.
    Front Integr Neurosci  2007;10:321
  151. Properties of GluR3 receptors tagged with GFP at the amino or carboxyl terminus.
    Authors: Limon Et al.
    Proc Natl Acad Sci U S A  2007;104:15526
  152. Glutathione levels modulate domoic acid induced apoptosis in mouse cerebellar granule cells.
    Authors: Giordano Et al.
    Toxicol Sci  2007;100:433
  153. Neurotoxicity of domoic Acid in cerebellar granule neurons in a genetic model of glutathione deficiency.
    Authors: Giordano Et al.
    Mol Pharmacol  2006;70:2116
  154. Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability.
    Authors: Jakubs Et al.
    Neuron  2006;52:1047
  155. Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking.
    Authors: Bäckström and Hyytiä
    Neuropsychopharmacology  2006;31:778
  156. Glial glutamate transporters maintain one-to-one relationship at the climbing fiber-Purkinje cell synapse by preventing glutamate spillover.
    Authors: Takayasu Et al.
    J Neurosci  2006;26:6563
  157. Regulated expression of HCN channels and cAMP levels shape the properties of the h current in developing rat hippocampus.
    Authors: Surges Et al.
    Mol Pain  2006;24:94
  158. Adaptation to synaptic inactivity in hippocampal neurons.
    Authors: Thiagarajan Et al.
    Neuron  2005;47:725
  159. Activation of NR2A-containing NMDA receptors is not obligatory for NMDA receptor-dependent long-term potentiation.
    Authors: Weitlauf Et al.
    Neurochem Int  2005;25:8386
  160. Programmed and induced phenotype of the hippocampal granule cells.
    Authors: Gómez-Lira Et al.
    J Neurosci  2005;25:6939
  161. Calcium increases in retinal glial cells evoked by light-induced neuronal activity.
    Authors: Newman
    Nat Methods  2005;25:5502
  162. Differences in transmission properties and susceptibility to long-term depression reveal functional specialization of ascending axon and parallel fiber synapses to Purkinje cells.
    Authors: Sims and Hartell
    EMBO Rep  2005;25:3246
  163. Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons.
    Authors: Calò Et al.
    J Neurosci  2005;25:2245
  164. Antinociceptive interactions between intrathecal gabap. and MK801 or NBQX in rat formalin test.
    Authors: Yoon Et al.
    J Korean Med Sci  2005;20:307
  165. Augmenting neurotransmitter release by enhancing the apparent Ca2+ affinity of synaptotagmin 1.
    Authors: Rhee Et al.
    J Neurosci  2005;102:18664
  166. Endocannabinoid-mediated metaplasticity in the hippocampus.
    Authors: Chevaleyre and Castillo
    Neuron  2004;43:871
  167. Glucose but not lactate in combination with acidosis aggravates ischemic neuronal death in vitro.
    Authors: Cronberg Et al.
    Proc Natl Acad Sci U S A  2004;35:753
  168. Brain-derived neurotrophic factor mRNA and protein are targeted to discrete dendritic laminas by events that trigger epileptogenesis.
    Authors: Tongiorgi Et al.
    Development  2004;24:6842
  169. Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons.
    Authors: Huang Et al.
    J Neurosci  2004;24:4551
  170. Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors.
    Authors: Fu Et al.
    J Neurophysiol  2003;90:3950
  171. DA controls the firing pattern of DA neurons via a network feedback mechanism.
    Authors: Paladini Et al.
    Proc Natl Acad Sci U S A  2003;100:2866
  172. A GDP/GTP exchange protein for the Rab3 small G protein family up-regulates a postdocking step of synaptic exocytosis in central synapses.
    Authors: Yamaguchi Et al.
    J Neurophysiol  2002;99:14536
  173. The suppression of brain cold-stable microtubules in mice induces synaptic defects associated with neuroleptic-sensitive behavioral disorders.
    Authors: Andrieux Et al.
    Genes Dev  2002;16:2350
  174. Glutamate antagonists limit tumor growth.
    Authors: Rzeski Et al.
    Proc Natl Acad Sci U S A  2001;98:6372
  175. Kainate receptor-mediated synaptic currents in cerebellar Golgi cells are not shaped by diffusion of glutamate.
    Authors: Bureau Et al.
    Proc Natl Acad Sci U S A  2000;97:6838
  176. Presynaptic N-MthD.-aspartate receptors at the parallel fiber-Purkinje cell synapse.
    Authors: Casado Et al.
    J Neurosci  2000;97:11593
  177. Histamine depolarizes cholinergic interneurones in the rat striatum via a H(1)-receptor mediated action.
    Authors: Bell Et al.
    Br J Pharmacol  2000;131:1135
  178. Calcium dynamics in single spines during coincident pre- and postsynaptic activity depend on relative timing of back-propagating action potentials and subthreshold excitatory postsynaptic potentials.
    Authors: Koester and Sakmann
    PLoS One  1998;95:9596
  179. Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N-MthD.-aspartic acid-receptors and phospholipase A2.
    Authors: Miettinen Et al.
    J Psychopharmacol  1997;94:6500
  180. Effect of chronic ethanol treatment in vivo on excitability in mouse cortical neurones in vitro.
    Authors: Ibbotson Et al.
    Br J Pharmacol  1997;122:956

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for NBQX

There are currently no reviews for this product. Be the first to review NBQX and earn rewards!

Have you used NBQX?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.