Home / RIP Kinase Inhibitors / Necrostatin-1

Necrostatin-1

Catalog #: 2324
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2324/50
2324/10
Necrostatin-1 | CAS No. 4311-88-0 | RIP Kinase Inhibitors
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Description: RIP1 kinase inhibitor; inhibits necroptosis

Chemical Name: 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone

Purity: ≥98%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Necrostatin-1 is an ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a specific cellular pathway, necroptosis, which leads to necrosis (EC50 = 494 nM). Reduces ischemic brain injury in a mouse model of stroke.

Technical Data

M.Wt:
259.33
Formula:
C13H13N3OS
Solubility:
Soluble to 30 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
4311-88-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Necrostatin-1

The citations listed below are publications that use Tocris products. Selected citations for Necrostatin-1 include:

4 Citations: Showing 1 - 4

  1. A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells.
    Authors: Chefetz Et al.
    Cell Rep  2019;26:3061
  2. ONC201 kills breast cancer cells in vitro by targeting mitochondria.
    Authors: Greer Et al.
    Oncotarget  2018;9:18454
  3. Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells
    Authors: Kim
    Journal of Translational Medicine  2017;15(1):123
  4. The small molecule NSC676914A is cytotoxic and differentially affects NFκB signaling in ovarian cancer cells and HEK293 cells.
    Authors: Sagher Et al.
    Cancer Cell Int  2014;14:75

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