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Nelfinavir mesylate

Catalog #: 3766
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Nelfinavir mesylate | CAS No. 159989-65-8 | HIV Protease Inhibitors
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Description: Potent HIV-1 protease inhibitor
Alternative Names: AG 1341

Chemical Name: (3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2- hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide methanesulfonate

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Nelfinavir mesylate is an orally active human immunodeficiency virus protease inhibitor. Potently inhibits HIV-1 protease (Ki = 2 nM) in vitro. Also exhibits anti-MERS-CoV activity in Vero cells in vitro (IC50 = 0.08 μM).

Technical Data

M.Wt:
663.89
Formula:
C32H45N3O4S.CH4O3S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
159989-65-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Nelfinavir, a lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy and apoptosis in vitro and in vivo.
    Gills et al.
    Clin.Cancer Res., 2007;13:5183
  2. Preclinical pharmacokinetics and distribution to tissue of AG1343, an inhibitor of human immunodeficiency virus type 1 protease.
    Shetty et al.
    Antimicrob.Agents Chemother., 1996;40:110
  3. Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease.
    Patick et al.
    Antimicrob.Agents Chemother., 1996;40:29
  4. The anti-HIV drug nelfinavir mesylate (Viracept) is a potent inhibitor of cell fusion caused by the SARSCoV-2 spike (S) glycoprotein warranting further evaluation as an antiviral against COVID-19 infections.
    Musarrat et al.
    J.Med.Virol., 2020;

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Citation for Nelfinavir mesylate

The citations listed below are publications that use Tocris products. Selected citations for Nelfinavir mesylate include:

1 Citation: Showing 1 - 1

  1. The anti-HIV drug nelfinavir mesylate (Viracept) is a potent inhibitor of cell fusion caused by the SARSCoV-2 spike (S) glycoprotein warranting further evaluation as an antiviral against COVID-19 infections.
    Authors: Vladimir Et al.
    J Med Virol  2020;92:2087-2095

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