NFAT Inhibitor
Purity: ≥95%
Biological Activity
NFAT Inhibitor is a selective inhibitor of calcineurin-mediated dephosphorylation of nuclear factor of activated T cells (NFAT). Does not disrupt other calcineurin-dependent pathways. Inhibits NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.
Aramburu et al.
Science, 1999;285:2129 -
Microglial phenotype is regulated by activity of the transcription factor, NFAT (Nuclear Factor of Activated T Cells).
Nagamoto-Combs and Combs
J.Neurosci., 2010;30:9641 -
Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules.
Roehrl et al.
Proc.Natl.Acad.Sci.USA, 2004;101:7554
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Citations for NFAT Inhibitor
The citations listed below are publications that use Tocris products. Selected citations for NFAT Inhibitor include:
2 Citations: Showing 1 - 2
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Intracellular Ca2+ Homeostasis and Nuclear Export Mediate Exit from Naive Pluripotency.
Authors: Bradley J Et al.
Cell Stem Cell 2019;25:210-224.e6
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Endothelial cells decode VEGF-mediated Ca2+ signaling patterns to produce distinct functional responses.
Authors: Noren Et al.
Sci Signal 2016;9:ra20
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