NNC 0640
Chemical Name: 4-[[(4-Cyclohexylphenyl)[[[3-(methylsulfonyl)phenyl]amino]carbonyl]amino]methyl]-N-2H-tetrazol-5-ylbenzamide
Purity: ≥98%
Biological Activity
NNC 0640 is a negative allosteric modulator of glucagon receptors (pKi = 7.4). Binds to external surface of the transmembrane domain. Also negative allosteric modulator of glucagon-like peptide 1 (GLP-1) receptor. Inhibits GLP-1-mediated cAMP accumulation in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Structure of the full-length glucagon class B g-protein-coupled receptor.
Zhang et al.
Nature., 2017;546:259 -
Extra-helical binding site of a glucagon receptor antagonist.
Jazayeri et al.
Nature., 2016;533:274 -
Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.
Song et al.
Nature., 2017;546:213
Product Datasheets
Reconstitution Calculator
Molarity Calculator
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for NNC 0640
There are currently no reviews for this product. Be the first to review NNC 0640 and earn rewards!
Have you used NNC 0640?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image