NS 8593 hydrochloride
Chemical Name: N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-1H-benzimidazol-2-amine hydrochloride
Purity: ≥98%
Biological Activity
NS 8593 hydrochloride is a selective KCa2 (SK) channel negative modulator; inhibits SK channel currents (Kd values are 0.42, 0.6 and 0.73 μM for SK1, SK2 and SK3 respectively at 0.5 μM Ca2+). Exhibits selectivity for SK channels over KCa1.1 (BK), KCa3.1 (IK), Kv, Nav and Cav channels. Inhibits afterhyperpolarization in hippocampal slices.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Synthesis and structure-activity relationship studies of 2-(N-substituted)-aminobenzimidazoles as potent negative gating modulators of small conductance Ca2+-activated K+ channels.
Sørensen
J.Med.Chem., 2008;51:7625 -
Negative gating modulation by (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine (NS8593) depends on residues in the inner pore vestibule: pharmacological evidence of deep-pore gating of KCa2 channels.
Jenkins et al.
Mol.Pharmacol., 2011;79:899 -
Inhibitory gating modulation of small conductance Ca2+-activated K+ channels by the synthetic compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reduces afterhyperpolarizing current in hip
Strøbaek et al.
Mol.Pharmacol., 2006;70:1771
Product Datasheets
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Citations for NS 8593 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for NS 8593 hydrochloride include:
3 Citations: Showing 1 - 3
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Structural mechanism of TRPM7 channel regulation by intracellular magnesium
Authors: Schmidt Et al.
Cell Mol Life Sci 2022;79:225
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TRPM7 activation potentiates SOCE in enamel cells but requires ORAI.
Authors: Yi Et al.
Cell Calcium 2020;87:102187
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Prostaglandin E2 increases migration and proliferation of human glioblastoma cells by activating transient receptor potential melastatin 7 channels.
Authors: Tian Et al.
J Cell Mol Med 2018;22:6327
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