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NSC 405020

Catalog #: 4902
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4902/10
4902/50
NSC 405020 | CAS No. 7497-07-6 | Synthetic Metalloprotease Inhibitors
1 Image
Description: Histone deacetylase inhibitor

Chemical Name: 3,4-Dichloro-N-(1-methylbutyl)benzamide

Purity: ≥99%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

NSC 405020 is a membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor (IC50 > 100 μmol/L). Directly interacts with the hemopexin domain (PEX) of MT1-MMP, affecting homodimerization and repressing its pro-tumorigenic activity in vivo. Displays no effect on the catalytic activity of MT1-MMP or MMP-2.

Technical Data

M.Wt:
260.16
Formula:
C12H15Cl2NO
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
7497-07-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Novel MT1-MMP Small-Molecule Inhibitors Based on Insights into Hemopexin Domain Function in Tumor Growth.
    Remacle AG, Golubkov VS, Shiryaev SA, Dahl R, Stebbins JL, Chernov AV, Cheltsov AV, Pellecchia M, Strongin AY.
    Cancer Res;72(9):2339-49.

Product Datasheets

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Citations for NSC 405020

The citations listed below are publications that use Tocris products. Selected citations for NSC 405020 include:

5 Citations: Showing 1 - 5

  1. Megakaryocytes form linear podosomes devoid of digestive properties to remodel medullar matrix.
    Authors: Bernard Et al.
    Sci Rep  2022;12:6255
  2. Basement membrane remodelling regulates mouse embryogenesis.
    Authors: Isabelle Et al.
    Nature  2020;582:253-258
  3. MMP Secretion Rate and Inter-invadopodia Spacing Collectively Govern Cancer Invasiveness.
    Authors: Kumar Et al.
    Biophys J  2018;114:650
  4. Mesenchymal stem cells differentially affect the invasion of distinct glioblastoma cell lines.
    Authors: Helena Et al.
    Oncotarget  2017;8:25482-25499
  5. Regulated delivery of molecular cargo to invasive tumour-derived microvesicles.
    Authors: Clancy Et al.
    Proc Natl Acad Sci U S A  2015;6:6919

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