NU 7026
Chemical Name: 2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one
Purity: ≥98%
Biological Activity
NU 7026 is an ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK). Displays selectivity over other PIKK family enzymes (IC50 values are 0.23, 13.0, > 100 and > 100 μM for DNA-PK, PI3K, ATM and ATR respectively). Radiosensitizes both proliferating and quiescent mouse embryonic fibroblast cells to IR and inhibits DSB repair.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-I.
Veuger et al.
Cancer Res., 2003;63:6008 -
Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2-(morpholin-4-yl)-benzo[h]chomen-4-one (NU7026)-mediated inhibition of DNA double-strand break repair via inhibition of DNA-dependent protein kinase.
Amrein et al.
J.Pharmacol.Exp.Ther., 2007;321:848
Product Datasheets
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Citations for NU 7026
The citations listed below are publications that use Tocris products. Selected citations for NU 7026 include:
14 Citations: Showing 1 - 10
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ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration.
Authors: Jaiswal Et al.
EMBO J 2017;36:2161
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Activation of NF-κB by human papillomavirus 16 E1 limits E1-dependent viral replication through degradation of E1.
Authors: Nakahara Et al.
Chembiochem 2015;89:5040
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DNA Damage Response Proteins and Oxygen Modulate Prostaglandin E2 Growth Factor Release in Response to Low and High LET Ionizing Radiation.
Authors: Allen Et al.
Front Oncol 2015;5:260
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Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema.
Authors: You Et al.
Elife 2015;4
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Spatio-temporal regulation of RAG2 following genotoxic stress.
Authors: Rodgers Et al.
DNA Repair (Amst) 2015;27:19
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DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells.
Authors: Dolman Et al.
PLoS One 2015;10:e0145744
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Mechanism of suppression of chromosomal instability by DNA polymerase POLQ.
Authors: Yousefzadeh Et al.
PLoS Genet 2014;10:e1004654
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Targeting XRCC1 deficiency in breast cancer for personalized therapy.
Authors: Sultana Et al.
Cancer Res 2013;73:1621
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The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway.
Authors: Fard Et al.
Cell Cycle 2013;13:408
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Expression of leukemia-associated fusion proteins increases sensitivity to histone deacetylase inhibitor-induced DNA damage and apoptosis.
Authors: Petruccelli Et al.
Mol Cancer Ther 2013;12:1591
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PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling.
Authors: Ando Et al.
Mol Cell 2012;47:681
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Detection of early Abl kinase activation after ionizing radiation by using a peptide biosensor.
Authors: Tang Et al.
J Neurosci 2012;13:665
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Oncolytic virus-mediated manipulation of DNA damage responses: synergy with chemotherapy in killing glioblastoma stem cells.
Authors: Kanai Et al.
J Natl Cancer Inst 2012;104:42
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Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome.
Authors: Bohgaki Et al.
PLoS Genet 2011;7:e1001381
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