Home / Catechol O-Methyltransferase (COMT) Inhibitors / OR-486

OR-486

Catalog #: 0483
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0483/50
OR-486 | CAS No. 7659-29-2 | Catechol O-Methyltransferase (COMT) Inhibitors
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Description: COMT inhibitor

Chemical Name: 3,5-Dinitrocatechol

Purity: ≥99%

Product Details
Citations (2)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

OR-486 is a potent and selective inhibitor of catechol-O-methyl-transferase.

Technical Data

M.Wt:
200.11
Formula:
C6H4N2O6
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
7659-29-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Rationale for selective COMT inhibitors as adjuncts in the drug treatment of Parkinson's disease.
    Mannisto and Kaakola
    Pharmacol.Toxicol., 1990;66:317
  2. Catechol-O-methyltransferase-inhibiting pyrocatechol derivatives: synthesis and structure-activity studies.
    Borgulya et al.
    Helv.Chim.Acta, 1989;72:952

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Citations for OR-486

The citations listed below are publications that use Tocris products. Selected citations for OR-486 include:

2 Citations: Showing 1 - 2

  1. Persistent catechol-O-methyltransferase-dependent pain is initiated by peripheral β-andrenergic receptors.
    Authors: Ciszek Et al.
    Anesthesiology  2016;124:1122
  2. OE increases cAMP in the oviductal secretory cells through a nongenomic mechanism.
    Authors: Oróstica Et al.
    Reproduction  2014;148:285

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