P 22077
Chemical Name: 1-[5-[(2,4-Difluorophenyl)thio]-4-nitro-2-thienyl]-ethanone
Purity: ≥99%
Biological Activity
P 22077 is an inhibitor of ubiquitin-specific protease (USP) 7 (EC50 = 8.6 μM); also inhibits the closely related deubiquitinase (DUB) USP47. Demonstrates downstream inhibition of HDM2 and claspin in vitro. Inhibits USP7-mediated p53 deubiquitination. Blocks deubiquitination of Tip60 (KAT5) histone lysine acetyltransferase.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Deubiquitination of Tip60 by USP7 determines the activity of the p53-dependent apoptotic pathway.
Dar et al.
Mol.Cell Biol., 2013;33:3309 -
Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.
Altun et al.
Chem.Biol., 2011;18:1401 -
Deubiquitylase, deSUMOylase, and deISGylase activity microarrays for assay of substrate preference and functional modifiers.
Loch et al.
Mol.Cell.Proteomics, 2011;10:M100.002402 -
Characterization of selective ubiquitin and ubiquitin-like protease inhibitors using a fluorescence-based multiplex assay format.
Tian et al.
Assay Drug Dev.Technol., 2011;9:165
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Citations for P 22077
The citations listed below are publications that use Tocris products. Selected citations for P 22077 include:
5 Citations: Showing 1 - 5
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USP7 and VCPFAF1 define the SUMO/Ubiquitin landscape at the DNA replication fork.
Authors: Oscar Et al.
Cell Rep 2021;37:109819
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Global feather orientations changed by electric current.
Authors: Ting-Xin Et al.
iScience 2021;24:102671
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USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin.
Authors: Ji Et al.
Nat Commun 2019;10:4184
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USP7 is a SUMO deubiquitinase essential for DNA replication.
Authors: Lecona Et al.
Nat Struct Mol Biol 2016;23:270
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USP7 cooperates with SCML2 to regulate the activity of PRC1.
Authors: Lecona Et al.
Pharmacol Res Perspect 2015;35:1157
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