PAC 1
Chemical Name: 4-(Phenylmethyl)-1-piperazineacetic acid [[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide
Purity: ≥98%
Biological Activity
PAC 1 is a procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC50 = 0.22 μM). Also activates procaspase-7 in a less efficient manner (EC50 = 4.5 μM). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC50 values are 0.003 - 1.41 and 5.02 - 9.98 μM respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy.
Putt et al.
Nat.Chem.Biol., 2006;2:543 -
Procaspase-3 activation as an anti-cancer strategy: structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3.
Peterson et al.
J.Med.Chem., 2009;52:5721
Product Datasheets
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Citations for PAC 1
The citations listed below are publications that use Tocris products. Selected citations for PAC 1 include:
2 Citations: Showing 1 - 2
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NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content.
Authors: Chiu Et al.
Cell Rep 2019;28:332
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Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size.
Authors: Yosefzon Et al.
Mol Cell 2018;70:573
FAQs
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