PACMA 31
Chemical Name: N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycylglycine ethyl ester
Purity: ≥99%
Biological Activity
PACMA 31 is an irreversible protein disulfide isomerase (PDI) inhibitor; inhibits growth of ovarian cancer cells. Suppresses tumor growth in a mouse xenograph model of human ovarian cancer.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment.
Xu et al.
Proc.Natl.Acad.Sci.U.S.A., 2012;109:16348 -
Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase.
Ge et al.
ACS.Chem.Biol., 2013;8:2577
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