Paliperidone
Chemical Name: 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
Purity: ≥98%
Biological Activity
Paliperidone is an atypical antipsychotic; metabolite of risperidone (Cat. No. 2865). Exhibits high affinity for 5-HT2A receptors (Ki = 0.4 nM for cloned human 5-HT2A receptors). Also displays nanomolar affinity for human D2 receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding.
Schotte et al.
Psychopharmacology, 1996;124:57 -
Risperidone: a novel antipsychotic with balanced serotonin-DA antagonism, receptor occupancy profile, and pharmacologic activity.
Leysen et al.
J.Clin.Psychiatry, 1994;55:5 -
Distinct electrophysiological effects of paliper. and risper. on the firing activity of rat serotonin and NE neurons.
Dremencov et al.
Psychopharmacology, 2007;194:63
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