Pam3CSK4

Catalog # Availability Size / Price Qty
4633/1
Pam3CSK4
1 Image
Description: TLR1/2 agonist; induces cytokine production

Purity: ≥95%

Product Details
Citations (3)
Supplemental Products
Reviews (1)

Biological Activity

Pam3CSK4 is a toll-like receptor 1/2 (TLR1/2) agonist; induces production of TNF-α and IL-6 in macrophages. Stimulates phosphorylation of p100/p110 and p60 in granulocytic-differentiated HL-60 cells. Promotes differentiation of naive CD4+ T cells into Th17 cells.

Technical Data

M.Wt:
1510.24
Formula:
C81H156N10O13S
Sequence:
CSKKKK

(Modifications: Cys-1 = S-[2,3-Bis(palmitoyloxy)-(2-R/S)-propyl]-N-palmitoyl]-Cys

Solubility:
Soluble to 1 mg/ml in 50% Ethanol / water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
112208-00-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Suppression of ?v?6 Integrin Expression by Polymicrobial Oral Biofilms in Gingival Epithelial Cells
    J Bi, L Koivisto, A Pang, M Li, G Jiang, S Aurora, Z Wang, GR Owen, J Dai, Y Shen, D Grenier, M Haapasalo, L Häkkinen, H Larjava
    Sci Rep, 2017;7(1):4411.
  2. Multifactorial Experimental Design to Optimize the Anti-Inflammatory and Proangiogenic Potential of Mesenchymal Stem Cell Spheroids
    KC Murphy, J Whitehead, PC Falahee, D Zhou, SI Simon, JK Leach
    Stem Cells, 2017;0(0):.
  3. High-density lipoprotein suppresses tumor necrosis factor alpha production by mycobacteria-infected human macrophages
    M Inoue, M Niki, Y Ozeki, S Nagi, EA Chadeka, T Yamaguchi, M Osada-Oka, K Ono, T Oda, F Mwende, Y Kaneko, M Matsumoto, S Kaneko, Y Ichinose, SM Njenga, S Hamano, S Matsumoto
    Sci Rep, 2018;8(1):6736.
  4. Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells.
    Offermanns et al.
    Biochem.J., 1992;282:551
  5. MF59 and Pam3CSK4 boost adaptive responses to influenza subunit vaccine through an IFN type I-independent mechanism of action.
    Caproni et al.
    J.Immunol., 2012;188:3088
  6. Toll-like receptor ligands induce the expression of IF.-gamma and interleukin-17 in chicken CD4+ T cells.
    St Paul et al.
    BMC Res.Notes, 2012;1:616

Product Datasheets

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Citations for Pam3CSK4

The citations listed below are publications that use Tocris products. Selected citations for Pam3CSK4 include:

3 Citations: Showing 1 - 3

FAQs

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Reviews for Pam3CSK4

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Good product!
By KANG LE on 04/24/2018

I use this product to activate TLR2


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