PAMP-12 (human, porcine)
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Description: Potent MRGPRX2 agonist
Purity: ≥95%
Biological Activity
PAMP-12 (human, porcine) is a potent endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 57.2 nM). Corresponds to amino acids 9 to 20 of proadrenomedullin.Technical Data
M.Wt:
1618.95
Formula:
C77H119N25O14
Sequence:
FRKKWNKWALSR
(Modification: Arg-12 = C-terminal amide)
Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
196305-05-2
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
In silico design of novel probes for the atypical opioid receptor MRGPRX2.
Lansu et al.
Nat.Chem.Biol., 2017;13:529 -
Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides.
Kamohara et al.
Biochem.Biophys.Res.Commun,, 2005;330:1146
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