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Pan Caspase Inhibitor Z-VAD-FMK

Catalog #: FMK001
204 Citations 2 Reviews Datasheet / COA / SDS
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FMK001
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Citations (204)
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Reviews (2)
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Pan Caspase Inhibitor Z-VAD-FMK Summary

 

Key Benefits

Cell permeable fluoromethyl ketone (FMK)-derivatized peptides act as effective irreversible Caspase inhibitors with no cytotoxic effects and, therefore, are useful tools for studying Caspase activity.

Specifications

Shipping Conditions
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Multi-Species

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Citations for Pan Caspase Inhibitor Z-VAD-FMK

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

204 Citations: Showing 1 - 10
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  1. Rotundifuran Induces Ferroptotic Cell Death and Mitochondria Permeability Transition in Lung Cancer Cells
    Authors: Kang, MJ;Moon, DO;Park, JY;Kim, N;Lee, SH;Ryu, HW;Huh, YH;Lee, HS;Kim, MO;
    Biomedicines  2024-03-05
  2. Blockade of isoprenoids biosynthesis by simvastatin induces autophagy-mediated cell death via downstream c-Jun N-terminal kinase activation and cell cycle dysregulation in canine T-cell lymphoma cells
    Authors: Kobayashi, K;Baba, K;Kambayashi, S;Okuda, M;
    Research in veterinary science  2024-02-06
  3. Promotion of ROS-mediated apoptosis, G2/M arrest, and autophagy by naringenin in non-small cell lung cancer
    Authors: Chang, TM;Chi, MC;Chiang, YC;Lin, CM;Fang, ML;Lee, CW;Liu, JF;Kou, YR;
    International journal of biological sciences  2024-01-21
  4. SIRT1 Regulates Hepatocyte Programmed Cell Death via GSDME - IL18 Axis in Human and Mouse Liver Transplantation
    Authors: Kadono, K;Kojima, H;Yao, S;Kageyama, S;Nakamura, K;Hirao, H;Ito, T;Dery, K;Farmer, D;Kaldas, F;Li, X;Kupiec-Weglinski, J;
    Research square  2023-06-27
  5. Necroptosis Induced by Delta-Tocotrienol Overcomes Docetaxel Chemoresistance in Prostate Cancer Cells
    Authors: M Montagnani, G Beretta, RM Moretti
    International Journal of Molecular Sciences, 2023-03-03;24(5):.  2023-03-03
  6. Mechanism of cis-Nerolidol-Induced Bladder Carcinoma Cell Death
    Authors: M Glumac, V ?ikeš ?uli, I Marinovi?-, M Radan
    Cancers, 2023-02-03;15(3):.  2023-02-03
  7. Dual inhibition of thioredoxin reductase and proteasome is required for auranofin-induced paraptosis in breast cancer cells
    Authors: MJ Seo, IY Kim, DM Lee, YJ Park, MY Cho, HJ Jin, KS Choi
    Cell Death & Disease, 2023-01-19;14(1):42.  2023-01-19
  8. Libertellenone T, a Novel Compound Isolated from Endolichenic Fungus, Induces G2/M Phase Arrest, Apoptosis, and Autophagy by Activating the ROS/JNK Pathway in Colorectal Cancer Cells
    Authors: CDB Gamage, JH Kim, Y Yang, ? Ta?, SY Park, R Zhou, S Pulat, M Varl?, JS Hur, SJ Nam, H Kim
    Cancers, 2023-01-12;15(2):.  2023-01-12
  9. JC2-11, a benzylideneacetophenone derivative, attenuates inflammasome activation
    Authors: G Lee, H Ahn, JH Yun, J Park, E Lee, S Oh, GS Lee
    Scientific Reports, 2022-12-28;12(1):22484.  2022-12-28
  10. AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology
    Authors: L Tilokani, FM Russell, S Hamilton, DM Virga, M Segawa, V Paupe, AV Gruszczyk, M Protasoni, LC Tabara, M Johnson, H Anand, MP Murphy, DG Hardie, F Polleux, J Prudent
    Science Advances, 2022-11-11;8(45):eabo7956.  2022-11-11
  11. TRAF3/p38-JNK Signalling Crosstalk with Intracellular-TRAIL/Caspase-10-Induced Apoptosis Accelerates ROS-Driven Cancer Cell-Specific Death by CD40
    Authors: K Ibraheem, AMA Yhmed, MM Nasef, NT Georgopoul
    Cells, 2022-10-18;11(20):.  2022-10-18
  12. Vitamin C Suppresses Pancreatic Carcinogenesis through the Inhibition of Both Glucose Metabolism and Wnt Signaling
    Authors: JH Kim, S Hwang, JH Lee, SS Im, J Son
    International Journal of Molecular Sciences, 2022-10-14;23(20):.  2022-10-14
  13. Inhibition of USP1 enhances anticancer drugs-induced cancer cell death through downregulation of survivin and miR-216a-5p-mediated upregulation of DR5
    Authors: SM Woo, S Kim, SU Seo, S Kim, JW Park, G Kim, YR Choi, K Hur, TK Kwon
    Cell Death & Disease, 2022-09-24;13(9):821.  2022-09-24
  14. DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells
    Authors: YS Michaels, JM Edgar, MC Major, EL Castle, C Zimmerman, T Yin, A Hagner, C Lau, HH Hsu, MI Ibañez-Rio, LJ Durland, DJHF Knapp, PW Zandstra
    Science Advances, 2022-08-24;8(34):eabn5522.  2022-08-24
  15. Isolation, Characterization and Biological Action of Type-1 Ribosome-Inactivating Proteins from Tissues of Salsola soda L
    Authors: N Landi, S Ragucci, L Citores, A Clemente, HZF Hussain, R Iglesias, JM Ferreras, A Di Maro
    Toxins, 2022-08-19;14(8):.  2022-08-19
  16. Magmas Inhibition in Prostate Cancer: A Novel Target for Treatment-Resistant Disease
    Authors: J Yang, BC Das, O Aljitawi, A Kumar, S Das, P Van Veldhu
    Cancers, 2022-05-31;14(11):.  2022-05-31
  17. Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations
    Authors: CR Bell, VS Pelly, A Moeini, SC Chiang, E Flanagan, CP Bromley, C Clark, CH Earnshaw, MA Koufaki, E Bonavita, S Zelenay
    Nature Communications, 2022-04-19;13(1):2063.  2022-04-19
  18. Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes
    Authors: D Beillevair, F Migneault, J Turgeon, D Gingras, AK Rimbaud, G Marcoux, C Spino, N Thibodeau, E Bonneil, P Thibault, É Boilard, M Dieudé, MJ Hébert
    Cell Death & Disease, 2022-02-11;13(2):145.  2022-02-11
  19. Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis
    Authors: W Deng, Y Bai, F Deng, Y Pan, S Mei, Z Zheng, R Min, Z Wu, W Li, R Miao, Z Zhang, TS Kupper, J Lieberman, X Liu
    Nature, 2022-02-02;0(0):.  2022-02-02
  20. FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury
    Authors: B Lee, Y Oh, E Cho, A DiAntonio, V Cavalli, JE Shin, HW Choi, Y Cho
    The Journal of Biological Chemistry, 2022-01-29;0(0):101647.  2022-01-29
  21. Galectin-9 Triggers Neutrophil-Mediated Anticancer Immunity
    Authors: N Ustyanovsk, G Choukrani, E Ammatuna, T Niki, E Cendrowicz, HJ Lourens, G Huls, VR Wiersma, E Bremer
    Biomedicines, 2021-12-29;10(1):.  2021-12-29
  22. Lucanthone, Autophagy Inhibitor, Enhances the Apoptotic Effects of TRAIL through miR-216a-5p-Mediated DR5 Upregulation and DUB3-Mediated Mcl-1 Downregulation
    Authors: JY Yoon, SM Woo, SU Seo, SR Song, SG Lee, TK Kwon
    International Journal of Molecular Sciences, 2021-12-21;23(1):.  2021-12-21
  23. Apigenin Induces Autophagy and Cell Death by Targeting EZH2 under Hypoxia Conditions in Gastric Cancer Cells
    Authors: TW Kim, HG Lee
    International Journal of Molecular Sciences, 2021-12-15;22(24):.  2021-12-15
  24. AKF-D52, a Synthetic Phenoxypyrimidine-Urea Derivative, Triggers Extrinsic/Intrinsic Apoptosis and Cytoprotective Autophagy in Human Non-Small Cell Lung Cancer Cells
    Authors: HS Gil, JH Lee, AK Farag, AHE Hassan, KS Chung, JH Choi, EJ Roh, KT Lee
    Oncogene, 2021-11-22;13(22):.  2021-11-22
  25. LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy
    Authors: P Li, Q Li, N Biswas, H Xin, T Diemer, L Liu, L Perez Guti, G Paternostr, C Piermarocc, S Domanskyi, RK Wang, N Ferrara
    Embo Molecular Medicine, 2021-11-15;0(0):e14511.  2021-11-15
  26. Apoptosis Enhances the Replication of Human Coronavirus OC43
    Authors: S Maharjan, M Kang, J Kim, D Kim, S Park, M Kim, K Baek, Y Lee, HJ Kwon
    Viruses, 2021-11-01;13(11):.  2021-11-01
  27. Species-Specific Inhibition of Necroptosis by HCMV UL36
    Authors: E Muscolino, C Castiglion, R Brixel, G Frascaroli, W Brune
    Viruses, 2021-10-22;13(11):.  2021-10-22
  28. PI3Kdelta coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T�cells at the expense of central memory
    Authors: JL Cannons, AV Villarino, SM Kapnick, S Preite, HY Shih, J Gomez-Rodr, Z Kaul, H Shibata, JM Reilley, B Huang, R Handon, IT McBain, S Gossa, T Wu, HC Su, DB McGavern, JJ O'Shea, PJ McGuire, G Uzel, PL Schwartzbe
    Cell Reports, 2021-10-12;37(2):109804.  2021-10-12
  29. Charting the N-Terminal Acetylome: A Comprehensive Map of Human NatA Substrates
    Authors: P Van Damme
    International Journal of Molecular Sciences, 2021-10-02;22(19):.  2021-10-02
  30. Parabens disrupt non-canonical inflammasome activation
    Authors: H Ahn, H Lee, G Lee, J Park, HW Sung, E Lee, GS Lee
    International immunopharmacology, 2021-09-30;101(0):108196.  2021-09-30
  31. Caspase-Dependent HMGB1 Release from Macrophages Participates in Peripheral Neuropathy Caused by Bortezomib, a Proteasome-Inhibiting Chemotherapeutic Agent, in Mice
    Authors: M Tsubota, T Miyazaki, Y Ikeda, Y Hayashi, Y Aokiba, S Tomita, F Sekiguchi, D Wang, M Nishibori, A Kawabata
    Cells, 2021-09-27;10(10):.  2021-09-27
  32. Inhibition of BMI-1 Induces Apoptosis through Downregulation of DUB3-Mediated Mcl-1 Stabilization
    Authors: K Wu, SM Woo, SU Seo, TK Kwon
    International Journal of Molecular Sciences, 2021-09-18;22(18):.  2021-09-18
  33. Selenium-GPX4 axis protects follicular helper T cells from ferroptosis
    Authors: Y Yao, Z Chen, H Zhang, C Chen, M Zeng, J Yunis, Y Wei, Y Wan, N Wang, M Zhou, C Qiu, Q Zeng, HS Ong, H Wang, FV Makota, Y Yang, Z Yang, N Wang, J Deng, C Shen, Y Xia, L Yuan, Z Lian, Y Deng, C Guo, A Huang, P Zhou, H Shi, W Zhang, H Yi, D Li, M Xia, J Fu, N Wu, JB de Haan, N Shen, W Zhang, Z Liu, D Yu
    Nature Immunology, 2021-08-19;22(9):1127-1139.  2021-08-19
  34. Synergistic Antitumor Activity of SH003 and Docetaxel via EGFR Signaling Inhibition in Non-Small Cell Lung Cancer
    Authors: MS Jeong, KW Lee, YJ Choi, YG Kim, HH Hwang, SY Lee, SE Jung, SA Park, JH Lee, YJ Joo, SG Cho, SG Ko
    International Journal of Molecular Sciences, 2021-08-05;22(16):.  2021-08-05
  35. The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output
    Authors: DC Kanellis, JA Espinoza, A Zisi, E Sakkas, J Bartkova, AM Katsori, J Boström, L Dyrskjøt, H Broholm, M Altun, SJ Elsässer, MS Lindström, J Bartek
    Science Advances, 2021-08-04;7(32):.  2021-08-04
  36. N-3-Hydroxy Dodecanoyl-DL-homoserine Lactone (OH-dDHL) Triggers Apoptosis of Bone Marrow-Derived Macrophages through the ER- and Mitochondria-Mediated Pathways
    Authors: K Woo, DH Kim, MH Oh, HS Park, CH Choi
    International Journal of Molecular Sciences, 2021-07-15;22(14):.  2021-07-15
  37. 3-Methyladenine prevents energy stress-induced necrotic death of melanoma cells through autophagy-independent mechanisms
    Authors: M Kosic, V Paunovic, B Ristic, A Mircic, M Bosnjak, D Stevanovic, T Kravic-Ste, V Trajkovic, L Harhaji-Tr
    Journal of pharmacological sciences, 2021-06-11;147(1):156-167.  2021-06-11
  38. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer
    Authors: C Mao, X Liu, Y Zhang, G Lei, Y Yan, H Lee, P Koppula, S Wu, L Zhuang, B Fang, MV Poyurovsky, K Olszewski, B Gan
    Nature, 2021-05-12;0(0):.  2021-05-12
  39. Characterization of HIV-induced remodeling reveals differences in infection susceptibility of memory CD4+ T�cell subsets in�vivo
    Authors: G Xie, X Luo, T Ma, J Frouard, J Neidleman, R Hoh, SG Deeks, WC Greene, NR Roan
    Cell Reports, 2021-04-27;35(4):109038.  2021-04-27
  40. Netrin-1 receptor UNC5C cleavage by active &delta-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies
    Authors: G Chen, SS Kang, Z Wang, EH Ahn, Y Xia, X Liu, IM Sandoval, FP Manfredsso, Z Zhang, K Ye
    Science Advances, 2021-04-16;7(16):.  2021-04-16
  41. Selective Anti-Cancer Effects of Plasma-Activated Medium and Its High Efficacy with Cisplatin on Hepatocellular Carcinoma with Cancer Stem Cell Characteristics
    Authors: Y Li, T Tang, HJ Lee, K Song
    International Journal of Molecular Sciences, 2021-04-12;22(8):.  2021-04-12
  42. ABT?737, a Bcl?2 family inhibitor, has a synergistic effect with apoptosis by inducing urothelial carcinoma cell necroptosis
    Authors: R Cheng, X Liu, Z Wang, K Tang
    Molecular Medicine Reports, 2021-03-31;23(6):.  2021-03-31
  43. Clustering of Tir during enteropathogenic E. coli infection triggers calcium influx-dependent pyroptosis in intestinal epithelial cells
    Authors: Q Zhong, TI Roumelioti, Z Kozik, M Cepeda-Mol, LÁ Fernández, AR Shenoy, C Bakal, G Frankel, JS Choudhary
    PloS Biology, 2020-12-30;18(12):e3000986.  2020-12-30
  44. Novel Small Molecular Compound AE-848 Potently Induces Human Multiple Myeloma Cell Apoptosis by Modulating the NF-&kappaB and PI3K/Akt/mTOR Signaling Pathways
    Authors: Y Xu, X Feng, Q Zhou, W Jiang, Y Dai, Y Jiang, X Liu, S Li, Y Wang, F Wang, A Li, C Zheng
    OncoTargets and Therapy, 2020-12-22;13(0):13063-13075.  2020-12-22
  45. Combined the SMAC mimetic and BCL2 inhibitor sensitizes neoadjuvant chemotherapy by targeting necrosome complexes in tyrosine aminoacyl-tRNA synthase-positive breast cancer
    Authors: KM Lee, H Lee, D Han, WK Moon, K Kim, HJ Oh, J Choi, EH Hwang, SE Kang, SA Im, KH Lee, HS Ryu
    Breast Cancer Res, 2020-11-25;22(1):130.  2020-11-25
  46. Induction of Lysosomal Membrane Permeabilization Is a Major Event of FTY720-Mediated Non-Apoptotic Cell Death in Human Glioma Cells
    Authors: KJ Min, TK Kwon
    Cancers (Basel), 2020-11-16;12(11):.  2020-11-16
  47. Synergistic apoptotic effects in cancer cells by the combination of CLK and Bcl-2 family inhibitors
    Authors: A Murai, S Ebara, S Sasaki, T Ohashi, T Miyazaki, T Nomura, S Araki
    PLoS ONE, 2020-10-16;15(10):e0240718.  2020-10-16
  48. Pharmacological Inhibition of WEE1 Potentiates the Antitumoral Effect of the dl922-947 Oncolytic Virus in Malignant Mesothelioma Cell Lines
    Authors: CA Iannuzzi, P Indovina, IM Forte, S Di Somma, AM Malfitano, M Bruno, G Portella, F Pentimalli, A Giordano
    Int J Mol Sci, 2020-10-04;21(19):.  2020-10-04
  49. The Pseudomonas aeruginosa protease LasB directly activates IL-1&beta
    Authors: J Sun, DL LaRock, EA Skowronski, JM Kimmey, J Olson, Z Jiang, AJ O'Donoghue, V Nizet, CN LaRock
    EBioMedicine, 2020-09-23;60(0):102984.  2020-09-23
  50. Reduction in MLKL-mediated endosomal trafficking enhances the TRAIL-DR4/5 signal to increase cancer cell death
    Authors: SY Park, HH Park, SY Park, SM Hong, S Yoon, MJ Morgan, YS Kim
    Cell Death Dis, 2020-09-11;11(9):744.  2020-09-11
  51. Cryptotanshinone chemosensitivity potentiation by TW-37 in human oral cancer cell lines by targeting STAT3-Mcl-1 signaling
    Authors: IH Yang, SH Hong, M Jung, CH Ahn, HJ Yoon, SD Hong, SD Cho, JA Shin
    Cancer Cell Int., 2020-08-26;20(0):405.  2020-08-26
  52. Upregulation of DR5 and Downregulation of Survivin by IITZ-01, Lysosomotropic Autophagy Inhibitor, Potentiates TRAIL-Mediated Apoptosis in Renal Cancer Cells via Ubiquitin-Proteasome Pathway
    Authors: SA Shahriyar, SU Seo, KJ Min, P Kubatka, DS Min, JS Chang, DE Kim, SM Woo, TK Kwon
    Cancers (Basel), 2020-08-21;12(9):.  2020-08-21
  53. Involvement of the NF-&kappaB signaling pathway in proliferation and invasion inhibited by Zwint-1 deficiency in Pancreatic Cancer Cells
    Authors: JH Kim, Y Youn, JC Lee, J Kim, JH Hwang
    Journal of Cancer, 2020-07-25;11(19):5601-5611.  2020-07-25
  54. Skp2 depletion reduces tumor-initiating properties and promotes apoptosis in synovial sarcoma
    Authors: J Wang, K Sato, E O'Donnell, A Singla, S Yaguare, O Aldahamshe, B Batko, H Borjihan, J Tingling, J Zhang, DA Weiser, DM Loeb, R Gorlick, EL Schwartz, R Yang, X Zi, H Zhao, DS Geller, BH Hoang
    Transl Oncol, 2020-07-02;13(10):100809.  2020-07-02
  55. Dual role of phosphatidylserine and its receptors in osteoclastogenesis
    Authors: JH Kang, HM Ko, GD Han, SY Lee, JS Moon, MS Kim, JT Koh, SH Kim
    Cell Death Dis, 2020-07-01;11(7):497.  2020-07-01
  56. Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid beta-Protein-Induced Synapse Loss in Alzheimer's Disease
    Authors: G Park, HS Nhan, SH Tyan, Y Kawakatsu, C Zhang, M Navarro, EH Koo
    Cell Rep, 2020-06-30;31(13):107839.  2020-06-30
  57. Asbestos conceives Fe(II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and beta-catenin induction in mesothelium
    Authors: F Ito, I Yanatori, Y Maeda, K Nimura, S Ito, T Hirayama, H Nagasawa, N Kohyama, Y Okazaki, S Akatsuka, S Toyokuni
    Redox Biol, 2020-06-24;36(0):101616.  2020-06-24
  58. Chrysophanol Regulates Cell Death, Metastasis, and Reactive Oxygen Species Production in Oral Cancer Cell Lines
    Authors: PC Hsu, CF Cheng, PC Hsieh, YH Chen, CY Kuo, HK Sytwu
    Evid Based Complement Alternat Med, 2020-05-26;2020(0):5867064.  2020-05-26
  59. Monoglyceride lipase mediates tumor-suppressive effects by promoting degradation of X-linked inhibitor of apoptosis protein
    Authors: R Liu, X Wang, C Curtiss, MS Sheikh, Y Huang
    Cell Death Differ., 2020-05-06;0(0):.  2020-05-06
  60. Osteogenic impact of pro-apoptotic caspase inhibitors in MC3T3-E1 cells
    Authors: A Kratochvíl, B Veselá, V Ledvina, E Švandová, K Klepárník, K Dadáková, P Beneš, E Matalová
    Sci Rep, 2020-05-04;10(1):7489.  2020-05-04
  61. PERK/NRF2 and autophagy form a resistance mechanism against G9a inhibition in leukemia stem cells
    Authors: JE Jang, JI Eom, HK Jeung, H Chung, YR Kim, JS Kim, JW Cheong, YH Min
    J. Exp. Clin. Cancer Res., 2020-04-15;39(1):66.  2020-04-15
  62. Combination of Arsenic Trioxide and Valproic Acid Efficiently Inhibits Growth of Lung Cancer Cells via G2/M-Phase Arrest and Apoptotic Cell Death
    Authors: HK Park, BR Han, WH Park
    Int J Mol Sci, 2020-04-10;21(7):.  2020-04-10
  63. Activation of JNK signaling promotes all-trans retinal-induced photoreceptor apoptosis in mice
    Authors: C Liao, B Cai, Y Feng, J Chen, Y Wu, J Zhuang, Z Liu, Y Wu
    J. Biol. Chem., 2020-04-07;0(0):.  2020-04-07
  64. Energy-stress-mediated AMPK activation inhibits ferroptosis
    Authors: H Lee, F Zandkarimi, Y Zhang, JK Meena, J Kim, L Zhuang, S Tyagi, L Ma, TF Westbrook, GR Steinberg, D Nakada, BR Stockwell, B Gan
    Nat. Cell Biol., 2020-02-06;22(2):225-234.  2020-02-06
  65. BAD sensitizes breast cancer cells to docetaxel with increased mitotic arrest and necroptosis
    Authors: J Mann, N Yang, R Montpetit, R Kirschenma, H Lemieux, IS Goping
    Sci Rep, 2020-01-15;10(1):355.  2020-01-15
  66. Regulation of Eosinophil Recruitment and Allergic Airway Inflammation by Tropomyosin Receptor Kinase A
    Authors: M Dileepan, XN Ge, I Bastan, YG Greenberg, Y Liang, P Sriramarao, SP Rao
    J. Immunol., 2019-12-23;0(0):.  2019-12-23
  67. Lercanidipine Synergistically Enhances Bortezomib Cytotoxicity in Cancer Cells via Enhanced Endoplasmic Reticulum Stress and Mitochondrial Ca2+ Overload
    Authors: AR Lee, MJ Seo, J Kim, DM Lee, IY Kim, MJ Yoon, H Hoon, KS Choi
    Int J Mol Sci, 2019-12-04;20(24):.  2019-12-04
  68. Non-SMC condensin I complex subunit H mediates mature chromosome condensation and DNA damage in pancreatic cancer cells
    Authors: JH Kim, Y Youn, KT Kim, G Jang, JH Hwang
    Sci Rep, 2019-11-29;9(1):17889.  2019-11-29
  69. Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin
    Authors: DE Kim, MET Dollé, WP Vermeij, A Gyenis, K Vogel, JHJ Hoeijmaker, CD Wiley, AR Davalos, P Hasty, PY Desprez, J Campisi
    Aging Cell, 2019-11-18;0(0):e13072.  2019-11-18
  70. PFKFB3 Inhibition Attenuates Oxaliplatin-Induced Autophagy and Enhances Its Cytotoxicity in Colon Cancer Cells
    Authors: S Yan, N Zhou, D Zhang, K Zhang, W Zheng, Y Bao, W Yang
    Int J Mol Sci, 2019-10-30;20(21):.  2019-10-30
  71. The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1
    Authors: SP O'Hara, PL Splinter, CE Trussoni, E Guicciardi, NP Splinter, MS Al Suraih, N Nasser-Gho, D Stollenwer, GJ Gores, NF LaRusso
    J. Biol. Chem., 2019-10-28;0(0):.  2019-10-28
  72. Pseudolaric Acid B Induces Growth Inhibition and Caspase-Dependent Apoptosis on Head and Neck Cancer Cell lines through Death Receptor 5
    Authors: SJ Choi, CH Ahn, IH Yang, B Jin, WW Lee, JH Kim, MH Ahn, N Swarup, KO Hong, JA Shin, NT Woo, SD Hong, JI Lee, SD Cho
    Molecules, 2019-10-16;24(20):.  2019-10-16
  73. Platelet IP6K1 regulates neutrophil extracellular trap-microparticle complex formation in acute pancreatitis
    Authors: R Madhi, M Rahman, D Taha, J Linders, M Merza, Y Wang, M Mörgelin, H Thorlacius
    JCI Insight, 2019-10-07;0(0):.  2019-10-07
  74. Evidence of necroptosis in osteoarthritic disease: investigation of blunt mechanical impact as possible trigger in regulated necrosis
    Authors: J Riegger, RE Brenner
    Cell Death Dis, 2019-09-17;10(10):683.  2019-09-17
  75. Glucocorticoids Oppose Thymocyte Negative Selection by Inhibiting Helios and Nur77
    Authors: PR Mittelstad, MD Taves, JD Ashwell
    J. Immunol., 2019-09-16;0(0):.  2019-09-16
  76. Solid state fermentation process with Aspergillus kawachii enhances the cancer-suppressive potential of silkworm larva in hepatocellular carcinoma cells
    Authors: HD Cho, HJ Min, YS Won, HY Ahn, YS Cho, KI Seo
    BMC Complement Altern Med, 2019-09-05;19(1):241.  2019-09-05
  77. Axl Inhibitor R428 Enhances TRAIL-Mediated Apoptosis Through Downregulation of c-FLIP and Survivin Expression in Renal Carcinoma
    Authors: SM Woo, KJ Min, SU Seo, S Kim, P Kubatka, JW Park, TK Kwon
    Int J Mol Sci, 2019-07-02;20(13):.  2019-07-02
  78. N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation
    Authors: D Yamasoba, K Sato, T Ichinose, T Imamura, L Koepke, S Joas, E Reith, D Hotter, N Misawa, K Akaki, T Uehata, T Mino, S Miyamoto, T Noda, A Yamashita, DM Standley, F Kirchhoff, D Sauter, Y Koyanagi, O Takeuchi
    Nat Microbiol, 2019-05-27;0(0):.  2019-05-27
  79. Caspase-1 initiates apoptosis in the absence of gasdermin D
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FAQs

  1. Does R&D Systems offer a negative control for Caspase Inihibitors with benzyloxycarbonyl group (Z-) at the N-terminus and the FMK functional group at the C-terminus?

    • Yes, R&D Systems offers Caspase Inhibitor Control Z-FA-FMK, Catalog # FMKC01, which is an inhibitor of cathepsins B and L but not caspases, and has been used in several systems as a negative control for peptide inhibitors of caspases.

  2. Are R&D Systems Caspase Inhibitors irreversible?

    • Yes, the majority of R&D Systems Caspase Inhibitors have a Fluoromethyl ketone (FMK) functional group on the C-terminus of the peptide, and act as effective irreversible inhibitors with no added cytotoxic effects. Inhibitors synthesized with a benzyloxycarbonyl group (also known as BOC or Z) at the N-terminus and O-methyl side chains exhibit enhanced cellular permeability.

      R&D Systems also offers a General Caspase Inhibitor, Q-VD-OPh, Catalog # OPH001, as well as a FITC-conjugated pan-caspase inhibitor (ApoStat), Catalog # FMK012, which are both cell-permeable, irreversible inhibitors of caspase activity.

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