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Pan Caspase OPH Inhibitor Q-VD, Non-omethylated

Catalog #: OPH001
36 Citations Datasheet / COA / SDS
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OPH001-01M
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Citations (36)
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Pan Caspase OPH Inhibitor Q-VD, Non-omethylated Summary

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Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
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Multi-Species

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Citations for Pan Caspase OPH Inhibitor Q-VD, Non-omethylated

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

36 Citations: Showing 1 - 10
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  1. Wogonin attenuates neutrophilic inflammation and airway smooth muscle proliferation through inducing caspase-dependent apoptosis and inhibiting MAPK/Akt signaling in allergic airways
    Authors: F Bai, Z Chen, S Xu, L Han, X Zeng, S Huang, Z Zhu, L Zhou
    International immunopharmacology, 2022-11-11;113(0):109410.  2022-11-11
  2. Phosphatidylserine externalization by apoptotic cells is dispensable for specific recognition leading to innate apoptotic immune responses
    Authors: MT Gomes, K Palasiewic, V Gadiyar, K Lahey, D Calianese, RB Birge, DS Ucker
    The Journal of Biological Chemistry, 2022-05-16;0(0):102034.  2022-05-16
  3. Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound
    Authors: TA Giovannucc, FA Salomons, M Haraldsson, LHM Elfman, M Wickström, P Young, T Lundbäck, J Eirich, M Altun, R Jafari, AL Gustavsson, JI Johnsen, NP Dantuma
    Cell Death & Disease, 2021-10-06;12(10):914.  2021-10-06
  4. The prohibitin-binding compound fluorizoline inhibits mitophagy in cancer cells
    Authors: S Núñez-Vázq, J Saura-Este, I Sánchez-Ve, E Guilbaud, AM Cosialls, G Pons, JE Ricci, D Iglesias-S, S Marchetti, J Gil
    Oncogenesis, 2021-09-27;10(9):64.  2021-09-27
  5. Impact of FasL Stimulation on Sclerostin Expression and Osteogenic Profile in IDG-SW3 Osteocytes
    Authors: A Kratochvil, A Ramesova, B Vesela, E Svandova, H Lesot, R Gruber, E Matalova
    Biology, 2021-08-07;10(8):.  2021-08-07
  6. Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis
    Authors: M Samuel, P Fonseka, R Sanwlani, L Gangoda, SH Chee, S Keerthikum, A Spurling, SV Chitti, D Zanker, CS Ang, I Atukorala, T Kang, S Shahi, AL Marzan, C Nedeva, C Vennin, MC Lucas, L Cheng, D Herrmann, M Pathan, D Chisanga, SC Warren, K Zhao, N Abraham, S Anand, S Boukouris, CG Adda, L Jiang, TM Shekhar, N Baschuk, CJ Hawkins, AJ Johnston, JM Orian, NJ Hoogenraad, IK Poon, AF Hill, M Jois, P Timpson, BS Parker, S Mathivanan
    Nature Communications, 2021-06-24;12(1):3950.  2021-06-24
  7. The Fragile X Mental Retardation Protein regulates RIP1K and colorectal cancer resistance to necroptosis
    Authors: A Di Grazia, I Marafini, G Pedini, D Di Fusco, F Laudisi, V Dinallo, E Rosina, C Stolfi, E Franzè, P Sileri, G Sica, G Monteleone, C Bagni, I Monteleone
    Cell Mol Gastroenterol Hepatol, 2020-10-19;0(0):.  2020-10-19
  8. In vitro analysis reveals necroptotic signaling does not provoke DNA damage or HPRT mutations
    Authors: MA Miles, CJ Hawkins
    Cell Death Dis, 2020-08-13;11(8):680.  2020-08-13
  9. Inhibiting Multiple Deubiquitinases to Reduce Androgen Receptor Expression in Prostate Cancer Cells
    Authors: A de Las Poz, T Reiner, V De Cesare, M Trost, C Perez-Stab
    Sci Rep, 2018-09-03;8(1):13146.  2018-09-03
  10. Cutting Edge: Blockade of Inhibitor of Apoptosis Proteins Sensitizes Neutrophils to TNF- but Not Lipopolysaccharide-Mediated Cell Death and IL-1? Secretion
    Authors: KW Chen, KE Lawlor, JB von Pein, D Boucher, M Gerlic, BA Croker, JS Bezbradica, JE Vince, K Schroder
    J. Immunol., 2018-04-16;0(0):.  2018-04-16
  11. Executioner caspases and CAD are essential for mutagenesis induced by TRAIL or vincristine
    Authors: MA Miles, CJ Hawkins
    Cell Death Dis, 2017-10-05;8(10):e3062.  2017-10-05
  12. Onset of microglial entry into developing quail retina coincides with increased expression of active caspase-3 and is mediated by extracellular ATP and UDP
    Authors: M Martín-Est, J Navascués, A Sierra-Mar, SM Martín-Gue, MA Cuadros, MC Carrasco, JL Marín-Teva
    PLoS ONE, 2017-08-01;12(8):e0182450.  2017-08-01
  13. Continuous treatment with FTS confers resistance to apoptosis and affects autophagy
    Authors: E Schmukler, E Wolfson, Z Elazar, Y Kloog, R Pinkas-Kra
    PLoS ONE, 2017-02-02;12(2):e0171351.  2017-02-02
  14. Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner
    Authors: SA Conos, KW Chen, D De Nardo, H Hara, L Whitehead, G N£¤ez, SL Masters, JM Murphy, K Schroder, DL Vaux, KE Lawlor, LM Lindqvist, JE Vince
    Proc. Natl. Acad. Sci. U.S.A, 2017-01-17;0(0):.  2017-01-17
  15. Effect of low doses of actinomycin D on neuroblastoma cell lines.
    Authors: Cortes C, Veiga S, Almacellas E, Hernandez-Losa J, Ferreres J, Kozma S, Ambrosio S, Thomas G, Tauler A
    Mol Cancer, 2016-01-04;15(1):1.  2016-01-04
  16. Foxo1 Is a T Cell-Intrinsic Inhibitor of the RORgammat-Th17 Program.
    Authors: Laine A, Martin B, Luka M, Mir L, Auffray C, Lucas B, Bismuth G, Charvet C
    J Immunol, 2015-07-13;195(4):1791-803.  2015-07-13
  17. Caspase-dependent Proteolysis of Human Ribonucleotide Reductase Small Subunits R2 and p53R2 during Apoptosis.
    Authors: Tebbi A, Guittet O, Tuphile K, Cabrie A, Lepoivre M
    J Biol Chem, 2015-04-15;290(22):14077-90.  2015-04-15
  18. RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.
    Authors: Lawlor K, Khan N, Mildenhall A, Gerlic M, Croker B, D'Cruz A, Hall C, Kaur Spall S, Anderton H, Masters S, Rashidi M, Wicks I, Alexander W, Mitsuuchi Y, Benetatos C, Condon S, Wong W, Silke J, Vaux D, Vince J
    Nat Commun, 2015-02-18;6(0):6282.  2015-02-18
  19. Neuronal exosomes facilitate synaptic pruning by up-regulating complement factors in microglia.
    Authors: Bahrini, Insaf, Song, Ji-hoon, Diez, Diego, Hanayama, Rikinari
    Sci Rep, 2015-01-23;5(0):7989.  2015-01-23
  20. CHCHD2 inhibits apoptosis by interacting with Bcl-x L to regulate Bax activation.
    Authors: Liu Y, Clegg H, Leslie P, Di J, Tollini L, He Y, Kim T, Jin A, Graves L, Zheng J, Zhang Y
    Cell Death Differ, 2014-12-05;22(6):1035-46.  2014-12-05
  21. Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells.
    Authors: Valenzuela M, Glorieux C, Stockis J, Sid B, Sandoval J, Felipe K, Kviecinski M, Verrax J, Buc Calderon P
    Br J Cancer, 2014-07-08;111(5):874-82.  2014-07-08
  22. PDK1 regulates B cell differentiation and homeostasis.
    Authors: Baracho G, Cato M, Zhu Z, Jaren O, Hobeika E, Reth M, Rickert R
    Proc Natl Acad Sci U S A, 2014-06-16;111(26):9573-8.  2014-06-16
  23. Phagocytosis of Staphylococcus aureus by human neutrophils prevents macrophage efferocytosis and induces programmed necrosis.
    Authors: Greenlee-Wacker M, Rigby K, Kobayashi S, Porter A, DeLeo F, Nauseef W
    J Immunol, 2014-04-11;192(10):4709-17.  2014-04-11
  24. Endothelial secreted factors suppress mitogen deprivation-induced autophagy and apoptosis in glioblastoma stem-like cells.
    Authors: Galan-Moya E, Treps L, Oliver L, Chneiweiss H, Vallette F, Bidere N, Gavard J
    PLoS ONE, 2014-03-28;9(3):e93505.  2014-03-28
  25. Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells.
    Authors: Yamaguchi, Hiroshi, Maruyama, Toshihik, Urade, Yoshihir, Nagata, Shigekaz
    Elife, 2014-03-25;3(0):e02172.  2014-03-25
  26. Disruption of autophagy by the histone deacetylase inhibitor MGCD0103 and its therapeutic implication in B-cell chronic lymphocytic leukemia.
    Authors: El-Khoury V, Pierson S, Szwarcbart E, Brons N, Roland O, Cherrier-De Wilde S, Plawny L, Van Dyck E, Berchem G
    Leukemia, 2014-01-14;28(8):1636-46.  2014-01-14
  27. Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung.
    Authors: Lucas, C D, Dorward, D A, Tait, M A, Fox, S, Marwick, J A, Allen, K C, Robb, C T, Hirani, N, Haslett, C, Duffin, R, Rossi, A G
    Mucosal Immunol, 2013-11-27;7(4):857-68.  2013-11-27
  28. Inhibition of Bim enhances replication of varicella-zoster virus and delays plaque formation in virus-infected cells.
    Authors: Liu, Xueqiao, Cohen, Jeffrey
    J Virol, 2013-11-13;88(2):1381-8.  2013-11-13
  29. Calpain-mediated degradation of MDMx/MDM4 contributes to HIV-induced neuronal damage.
    Authors: Colacurcio D, Yeager A, Kolson D, Jordan-Sciutto K, Akay C
    Mol Cell Neurosci, 2013-10-12;57(0):54-62.  2013-10-12
  30. The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.
    Authors: Murphy J, Czabotar P, Hildebrand J, Lucet I, Zhang J, Alvarez-Diaz S, Lewis R, Lalaoui N, Metcalf D, Webb A, Young S, Varghese L, Tannahill G, Hatchell E, Majewski I, Okamoto T, Dobson R, Hilton D, Babon J, Nicola N, Strasser A, Silke J, Alexander W
    Immunity, 2013-09-05;39(3):443-53.  2013-09-05
  31. Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members.
    Authors: Suzuki, Jun, Fujii, Toshihir, Imao, Takeshi, Ishihara, Kenji, Kuba, Hiroshi, Nagata, Shigekaz
    J Biol Chem, 2013-03-26;288(19):13305-16.  2013-03-26
  32. pRb/E2F-1-mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2/Bcl-xL inhibitor ABT-737.
    Authors: Bertin-Ciftci J, Barre B, Le Pen J, Maillet L, Couriaud C, Juin P, Braun F
    Cell Death Differ, 2013-02-22;20(5):755-64.  2013-02-22
  33. CD40 stimulation sensitizes CLL cells to lysosomal cell death induction by type II anti-CD20 mAb GA101.
    Authors: Jak M, van Bochove GG, Reits EA
    Blood, 2011-09-26;118(19):5178-88.  2011-09-26
  34. IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H).
    Authors: Jones JL, Phuah CL, Cox AL, Thompson SA, Ban M, Shawcross J, Walton A, Sawcer SJ, Compston A, Coles AJ
    J. Clin. Invest., 2009-06-22;119(7):2052-61.  2009-06-22
  35. Theiler's virus-induced intrinsic apoptosis in M1-D macrophages is Bax mediated and restricts virus infectivity: a mechanism for persistence of a cytolytic virus.
    Authors: Son KN, Becker RP, Kallio P, Lipton HL
    J. Virol., 2008-02-20;82(9):4502-10.  2008-02-20
  36. The microtubule-targeting agent CA4P regresses leukemic xenografts by disrupting interaction with vascular cells and mitochondrial-dependent cell death.
    Authors: Petit I, Karajannis MA, Vincent L, Young L, Butler J, Hooper AT, Shido K, Steller H, Chaplin DJ, Feldman E, Rafii S
    Blood, 2007-11-16;111(4):1951-61.  2007-11-16

FAQs

  1. Are R&D Systems Caspase Inhibitors irreversible?

    • Yes, the majority of R&D Systems Caspase Inhibitors have a Fluoromethyl ketone (FMK) functional group on the C-terminus of the peptide, and act as effective irreversible inhibitors with no added cytotoxic effects. Inhibitors synthesized with a benzyloxycarbonyl group (also known as BOC or Z) at the N-terminus and O-methyl side chains exhibit enhanced cellular permeability.

      R&D Systems also offers a General Caspase Inhibitor, Q-VD-OPh, Catalog # OPH001, as well as a FITC-conjugated pan-caspase inhibitor (ApoStat), Catalog # FMK012, which are both cell-permeable, irreversible inhibitors of caspase activity.

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