Home / Additional GABA Compounds / Pentylenetetrazole

Pentylenetetrazole

Catalog #: 2687
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2687/1G
Pentylenetetrazole | CAS No. 54-95-5 | Additional GABA Compounds
1 Image
Description: CNS stimulant
Alternative Names: PTZ

Chemical Name: 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine

Purity: ≥99%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Pentylenetetrazole is a cNS stimulant that induces kindling in vivo. Causes alterations in excitatory and inhibitory neurotransmitter systems.

Technical Data

M.Wt:
138.17
Formula:
C6H10N4
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
54-95-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The mTOR inhibitor rapamycin has limited acute anticonvulsant effects in mice.
    Hartman A, Santos P, Dolce A, Hardwick J
    PLoS ONE, 2012;7(9):e45156.
  2. Pentylenetetrazol-induced kindling: early involvement of excitatory and inhibitory systems.
    Rocha et al.
    Epilepsy Res., 1996;26:105
  3. Acute pentylenetetrazol injection reduces rat GABAA receptor mRNA levels and GABA stimulation of benzodiazepine binding with no effect on benzodiazepine binding site density.
    Walsh et al.
    J.Pharmacol.Exp.Ther., 1999;289:1626
  4. Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: possible mechanism of action.
    Dhir et al.
    Prog.Neuro-Psychopharm.Biol.Psychiat., 2006;30:1478

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for Pentylenetetrazole

The citations listed below are publications that use Tocris products. Selected citations for Pentylenetetrazole include:

1 Citation: Showing 1 - 1

  1. 2'-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors.
    Authors: Karim Et al.
    Br J Pharmacol  2012;165:880

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Pentylenetetrazole

There are currently no reviews for this product. Be the first to review Pentylenetetrazole and earn rewards!

Have you used Pentylenetetrazole?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.