Home / Phosphodiesterase Inhibitors / PF 05180999

PF 05180999

Catalog #: 6405 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6405/5
6405/25
PF 05180999 | CAS No. 1394033-54-5 | Phosphodiesterase Inhibitors
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Description: Potent and selective PDE2A inhibitor

Chemical Name: 4-(1-Azetidinyl)-7-methyl-5-[1-methyl-5-[5-(trifluoromethyl)-2-pyridinyl]-1H-pyrazol-4-yl]-imidazo[5,1-f][1,2,4]triazine

Purity: ≥98%

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Biological Activity

PF 05180999 is a potent and selective PDE2A inhibitor (IC50 = 1 nM). Exhibits 2000-fold selectivity for PDE2A over PDE10A. Brain penetrant.

Technical Data

M.Wt:
414.39
Formula:
C19H17F3N8
Solubility:
Soluble to 50 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1394033-54-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

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