PF 06273340

Catalog # Availability Size / Price Qty
6115/10
PF 06273340 | CAS No. 1402438-74-7 | Trk Receptor Inhibitors
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Description: Potent and selective pan-Trk inhibitor; peripherally restricted

Chemical Name: N-[5-[[2-Amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl]-3-pyridinyl]-5-chloro-2-pyridineacetamide

Purity: ≥98%

Product Details
Citations (1)
Supplemental Products
Reviews (1)

Biological Activity

PF 06273340 is a potent and selective pan-Trk inhibitor (IC50 values are 1, 2 and 6 nM for Trk C, B and A, respectively). Selective for Trk over a panel of ion channels, receptors and other enzymes. Peripherally restricted. Exhibits efficacy in a rodent model of inflammatory pain. Orally bioavailable.

Technical Data

M.Wt:
479.93
Formula:
C23H22ClN7O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
1402438-74-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

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Citation for PF 06273340

The citations listed below are publications that use Tocris products. Selected citations for PF 06273340 include:

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Assessing the efficacy on cancer cells
By Anonymous on 09/08/2017

Measured cancer cell viability upon treatment with this drug at various concentrations including 5 and 10 uM. In addition, compared it to a specific siRNA.


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