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PF 5006739

Catalog #: 6346 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6346/25
6346/5
PF 5006739 | CAS No. 1293395-67-1 | Casein Kinase 1 Inhibitors
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Description: Potent CK1δ/ε inhibitor

Chemical Name: 4-[4-(4-Fluorophenyl)-1-[1-(3-isoxazolylmethyl)-4-piperidinyl]-1H-imidazol-5-yl]-2-pyrimidinamine

Purity: ≥98%

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Biological Activity

PF 5006739 is a potent casein kinase 1δ/ε inhibitor (IC50 values are 3.9 and 17 nM, respectively). Mediates circadian rhythm phase-delaying effects in vivo. Attenuates opioid drug seeking behavior in addiction in vivo models.

Technical Data

M.Wt:
419.46
Formula:
C22H22FN7O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1293395-67-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Casein kinase 1δ/ε inhibitor PF-5006739 attenuates opioid drug-seeking behavior.
    Wager et al.
    ACS Chem.Neurosci., 2014;5:1253

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