Piceatannol
Chemical Name: 4-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,2-benzenediol
Purity: ≥98%
Biological Activity
Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. Inhibits p56lck and syk protein tyrosine kinases and inhibits TNF-induced NF-κB activation and gene expression. Synthesis results from conversion of resveratrol (Cat. No. 1418) by cytochrome P450 1B1.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Piceatannol inhibits TNF-induced NF-kB activation and NF-kB-mediated gene expression through suppression of IkBa kinase and p65 phosphorylation.
Ashikawa et al.
J.Immunol., 2002;169:6490 -
Piceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor.
Geahlen and McLaughlin
Biochem.Biophys.Res.Commun., 1989;165:241 -
The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1.
Potter et al.
Br.J.Cancer, 2002;86:774 -
Inhibition of mast cell FceR1-mediated signalling and effector function by the syk-selective inhibitor, piceatannol.
Oliver et al.
J.Biol.Chem., 1994;269:29697
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Citations for Piceatannol
The citations listed below are publications that use Tocris products. Selected citations for Piceatannol include:
8 Citations: Showing 1 - 8
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Type II cytokines impair host defense against an intracellular fungal pathogen by amplifying macrophage generation of IL-33.
Authors: Verma Et al.
J Neurosci 2015;8:380
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TH2 cells and their cytokines regulate formation and function of lymphatic vessels.
Authors: Shin Et al.
Nat Commun 2015;6:6196
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Antibody-opsonized bacteria evoke an inflammatory dendritic cell phenotype and polyfunctional Th cells by cross-talk between TLRs and FcRs.
Authors: Bakema Et al.
J Immunol 2015;194:1856
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A novel and essential role for FcγRIIa in cancer cell-induced platelet activation.
Authors: Mitrugno Et al.
Blood 2014;123:249
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An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling.
Authors: Siddoway Et al.
J Neurosci 2013;33:11206
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Piceatannol enhances cisp. sensitivity in ovarian cancer via modulation of p53, X-linked inhibitor of apoptosis protein (XIAP), and mitochondrial fission.
Authors: Farrand Et al.
J Biol Chem 2013;288:23740
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A "genome-to-lead" approach for insecticide discovery: pharmacological characterization and screening of Aedes aegypti D(1)-like DA receptors.
Authors: Meyer Et al.
PLoS Negl Trop Dis 2012;6:e1478
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The ITK-SYK fusion oncogene induces a T-cell lymphoproliferative disease in mice mimicking human disease.
Authors: Dierks Et al.
Cancer Res 2010;70:6193
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