Piclamilast
Chemical Name: 3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide
Purity: ≥99%
Biological Activity
Piclamilast is a potent and selective inhibitor of phosphodiesterase (PDE) 4 (IC50 = 1 nM at PDE4 from human neutrophils). Displays >19,000-fold selectivity over other PDE isoenzymes. Exhibits anti-inflammatory effects in models of allergic inflammation. Also inhibits LTB4 synthesis in human neutrophils (IC50 = 2 nM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Anti-inflammatory and bronchodilator properties of RP 73401, a novel and selective phosphodiesterase type IV inhibitor.
Raeburn et al.
Br.J.Pharmacol., 1994;113:1423 -
Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipram.
Zhao et al.
J.Pharmacol.Exp.Ther., 2003;305:565 -
Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflum. in vitro.
Hatzelmann and Schudt
J.Pharmacol.Exp.Ther., 2001;297:267
Product Datasheets
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Citation for Piclamilast
The citations listed below are publications that use Tocris products. Selected citations for Piclamilast include:
1 Citation: Showing 1 - 1
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PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy.
Authors: Zhang Et al.
Sci Adv 2019;5:eaaw5870
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