Picropodophyllotoxin
Chemical Name: (5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Purity: ≥97%
Biological Activity
Picropodophyllotoxin is an orally active insulin-like growth factor 1 receptor (IGF1R) inhibitor that exhibits no activity at the insulin receptor, FGFR, PDGFR or EGFR. Inhibits IGF1R autophosphorylation (IC50 ~ 1 nM), increases the fraction of cells in the G2/M phase and upregulates apoptosis. Exhibits antiproliferative effects in multiple cancer cell lines (IC50 = 0.05 - 15 μM), and has anticancer and antineovascularization activity in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Cyclolignans as inhibitors of the Ins-like growth factor-1 receptor and malignant cell growth.
Girnita et al.
Cancer Res., 2004;64:236 -
IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells.
Stromberg et al.
Blood, 2006;107:669 -
Inhibition of VEGF secretion and experimental choroidal neovascularization by picropodophyllin (PPP), an inhibitor of the Ins-like growth factor-1 receptor.
Economou et al.
Invest.Ophthalmol.Vis.Sci., 2008;49:2620
Product Datasheets
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Citations for Picropodophyllotoxin
The citations listed below are publications that use Tocris products. Selected citations for Picropodophyllotoxin include:
3 Citations: Showing 1 - 3
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Macrophage-derived Ins.-like growth factor-1 is a key neurotrophic and nerve-sensitizing factor in pain associated with endometriosis.
Authors: Forster Et al.
FASEB J 2019;:fj201900797R
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Picropodophyllin (PPP) is a potent rhabdomyosarcoma growth inhibitor both in vitro and in vivo.
Authors: Tarnowski
BMC Cancer 2017;17(1):532
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Ins enhances striatal DA release by activating cholinergic interneurons and thereby signals reward.
Authors: Stouffer Et al.
Nat Commun 2015;6:8543
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