PMX 205

Catalog #: 5196
2 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
5196/1

1 Image

Description: Potent C5a receptor peptide antagonist

Purity: ≥95%

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Product Details

Citations (2)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

PMX 205 is a potent C5a receptor peptide antagonist (IC₅₀ = 31 nM). Ameliorates experimentally-induced colon inflammation in mice. Reduces fibrillar amyloid deposits, decreases hyperphosphorylated tau levels and rescues cognitive function in a mouse model of Alzheimer's disease. Also improves hindlimb grip strength and slows disease progression in the hSOD1^G93A mouse model of amyotrophic lateral sclerosis. Orally active and brain penetrant.

Technical Data

M.Wt:

839.05

Formula:

C₄₅H₆₂N₁₀O₆

Sequence:

XPXWR

(Modifications: X-1 = N²-(1-Oxo-3-phenylpropyl)-Orn, X-3 = D-Cha, Lactam bridge: Orn-1 to Arg-5)

Solubility:

Soluble to 1 mg/ml in water with sonication

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

514814-49-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Pharmacological inhibition of complement C5a-C5a₁ receptor signalling ameliorates disease pathology in the hSOD1^G93A mouse model of amyotrophic lateral sclerosis.
Lee et al.
Br.J.Pharmacol., 2017;174:689
Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in mice.
Kumar et al.
Sci.Rep., 2018;8:8101
Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity.
March et al.
Mol.Pharmacol., 2004;65:868
Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease.
Fonseca et al.
J.Immunol., 2009;183:1375
The C5a receptor antagonist PMX205 ameliorates experimentally induced colitis associated with increased IL-4 and IL-10.
Jain et al.
Br.J.Pharmacol., 2013;168:488

Product Datasheets

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for PMX 205

The citations listed below are publications that use Tocris products. Selected citations for PMX 205 include:

2 Citations: Showing 1 - 2

Zebrafish fin regeneration involves generic and regeneration-specific osteoblast injury responses.
Authors: Markus Et al.
Elife 2022;11
Complement Receptor C5aR1 Plays an Evolutionarily Conserved Role in Successful Cardiac Regeneration.
Authors: Natarajan Et al.
Circulation 2018;137:2152

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