PNU 74654
Chemical Name: 2-Phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydrazide
Purity: ≥99%
Biological Activity
Binds to β-catenin (KD = 450 nM). Inhibits the interaction between β-catenin and T cell factor 4 (Tcf4) and disrupts the Wnt signaling pathway. Promotes neural differentiation of hPSCs as part of a chemical cocktail.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening.
Trosset et al.
Proteins, 2006;64:60 -
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.
Wells and McClendon
Nature, 2007;450:1001 -
Chemically defined neural conversion of human pluripotent stem cells.
Chen et al.
Methods Mol.Biol., 2019;1919:59
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Citations for PNU 74654
The citations listed below are publications that use Tocris products. Selected citations for PNU 74654 include:
9 Citations: Showing 1 - 9
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FSCN1 as a new druggable target in adrenocortical carcinoma.
Authors: Margaret E Et al.
Int J Cancer 2023;153:210-223
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α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss.
Authors: Juan C Et al.
J Neurosci 2021;41:2264-2273
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Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior.
Authors: Stephen J Et al.
Genes Dev 2021;35:1527-1547
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Chemically defined neural conversion of human pluripotent stem cells.
Authors: Chen Et al.
Methods Mol.Biol. 2019;1919:59
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Transcription factor binding dynamics during human ES cell differentiation.
Authors: Tsankov Et al.
Stem Cells Int 2015;518:344
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Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells.
Authors: Liao Et al.
Nature 2015;47:469
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Inhibition of G9a Histone Methyltransferase Converts Bone Marrow Mesenchymal Stem Cells to Cardiac Competent Progenitors.
Authors: Yang Et al.
Cell Reprogram 2015;2015:270428
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β-Cell differentiation of human pancreatic duct-derived cells after in vitro expansion.
Authors: Corritore Et al.
Ann Neurol 2014;16:456
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Genome-wide RNAi screen reveals a new role of a WNT/CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses.
Authors: Baril Et al.
PLoS Pathog 2013;9:e1003416
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