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Polygodial

Catalog #: 3197
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3197/10
3197/50
Polygodial | CAS No. 6754-20-7 | TRPA1 Activators
1 Image
Description: TRPA1 channel activator; analgesic and antifungal

Chemical Name: (1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde

Purity: ≥97%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Polygodial is a TRPA1 channel activator (EC50 = 400 nM) that is selective against TRPV1, TRPV2, TRPV3, TRPV4 and TRPM8 channels. Acts as an analgesic via desensitization of sensory neurons. Also exhibits antifungal activity via inhibition of mitochondrial ATPase.

Technical Data

M.Wt:
234.33
Formula:
C15H22O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
6754-20-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Effect of polygodial on the mitochondrial ATPase of Saccharomyces cerevisiae.
    Lunde and Kubo
    Antimicrob.Agents Chemother., 2000;44:1943
  2. TRPA1 mediates the noxious effects of natural sesquiterpene deterrents.
    Escalera et al.
    J.Biol.Chem., 2008;283:24136

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Citations for Polygodial

The citations listed below are publications that use Tocris products. Selected citations for Polygodial include:

2 Citations: Showing 1 - 2

  1. Transient Receptor Potential Ankyrin-1-expressing vagus nerve fibers mediate IL-1� induced hypothermia and reflex anti-inflammatory responses.
    Authors: Silverman Et al.
    Mol Med  2023;29:4
  2. Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction.
    Authors: Shi Et al.
    Mol Cancer  2015;21:4852

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