PQ 401
Chemical Name: N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)urea
Purity: ≥99%
Biological Activity
PQ 401 is an insulin-like growth factor receptor (IGF1R) inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC50 value of 12 μM. Inhibits growth of MCF-7 breast cancer cells in vitro and in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Parallel synthesis of diarylureas and their evaluation as inhibitors of Ins-like growth factor receptor.
Anderson et al.
J.Comb.Chem., 2006;8:784
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Citations for PQ 401
The citations listed below are publications that use Tocris products. Selected citations for PQ 401 include:
5 Citations: Showing 1 - 5
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Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli.
Authors: Ilatovskaya Et al.
Am J Physiol Cell Physiol 2013;305:C1050
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Ins-like growth factor (IGF) binding protein 2 functions coordinately with receptor protein tyrosine phosphatase β and the IGF-I receptor to regulate IGF-I-stimulated signaling.
Authors: Shen Et al.
Mol Cell Biol 2012;32:4116
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Ins-like growth factor 1-mediated hyperthermia involves anterior hypothalamic Ins receptors.
Authors: Sanchez-Alavez Et al.
J Biol Chem 2011;286:14983
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Activation of the Ins-like growth factor-1 receptor induces resistance to epidermal growth factor receptor antagonism in head and neck squamous carcinoma cells.
Authors: Jameson Et al.
Mol Cancer Ther 2011;10:2124
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Ins-like growth factor-I-stimulated Ins receptor substrate-1 negatively regulates Src homology 2 domain-containing protein-tyrosine phosphatase substrate-1 function in vascular smooth muscle cells.
Authors: Radhakrishnan Et al.
J Biol Chem 2010;285:15682
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