Pregnanolone

Catalog #: 3652 Datasheet / COA / SDS

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3652/50

Pregnanolone | CAS No. 128-20-1 | GABA-A Receptor Modulators

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Description: Postitive allosteric modulator of GABAA receptors

Chemical Name: (3α,5β)-3-Hydroxy-pregnan-20-one

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Biological Activity

Pregnanolone is a GABA_A receptor positive allosteric modulator. Neuroactive steroid.

Technical Data

M.Wt:

318.49

Formula:

C₂₁H₃₄O₂

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Storage:

Store at RT

CAS No:

128-20-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Structure-activity relationships for steroid interaction with the γ-aminobutyric acid_A receptor complex.
Harrison et al.
J.Pharmacol.Exp.Ther., 1987;241:346
Differential modulation of the γ-aminobutyric acid type C receptor by neuroactive steroids.
Morris et al.
Mol.Pharmacol., 1999;56:752

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