Propranolol hydrochloride
Chemical Name: (RS)-1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol hydrochloride
Biological Activity
Propranolol hydrochloride is an β-adrenergic antagonist.R-enantiomer, S-enantiomer and Glycol Metabolite also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Effects of propra. treatment on left ventricular function and intracellular calcium regulation in rats with postinfarction heart failure.
Litwin et al.
Br.J.Pharmacol., 1999;127:1671 -
The inhibitory effect of propra. on ATP-sensitive potassium channels in neonatal rat heart.
Xie et al.
Br.J.Pharmacol., 1998;123:599
Product Datasheets
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Citations for Propranolol hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Propranolol hydrochloride include:
13 Citations: Showing 1 - 10
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A ventrolateral medulla-midline thalamic circuit for hypoglycemic feeding
Authors: Beas Et al.
Nat Commun 2020;11:6218
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Complex Formation between VEGFR2 and the β2-Adrenoceptor.
Authors: Kilpatrick Et al.
Cell Chem Biol 2019;26:830
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An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes.
Authors: McKeithan Et al.
Front Physiol 2017;8:766
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Negative cooperativity across β1-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 β1-adrenoceptor binding conformation.
Authors: Gherbi Et al.
FASEB J 2015;29:2859
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Locus Coeruleus Stimulation Facilitates Long-Term Depression in the Dentate Gyrus That Requires Activation of β-Adrenergic Receptors.
Authors: Hansen and Manahan-Vaughan
Mol Cancer 2015;25:1889
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Burn Induces Browning of the Subcutaneous White Adipose Tissue in Mice and Humans.
Authors: Patsouris Et al.
Cereb Cortex 2015;13:1538
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Application of BRET to monitor ligand binding to GPCRs.
Authors: Stoddart Et al.
Nat Methods 2015;12:661
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Chronic treatment with pra. or dulox. lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use.
Authors: Skelly and Weiner
Brain Behav 2014;4:468
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Medullary NE neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis.
Authors: Bucher Et al.
J Cereb Blood Flow Metab 2014;34:1128
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Detection of the secondary, low-affinity β1 -adrenoceptor site in living cells using the fluorescent CGP 12177 derivative BODIPY-TMR-CGP.
Authors: Gherbi Et al.
Br J Pharmacol 2014;171:5431
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Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons.
Authors: Rankovic Et al.
PLoS One 2011;6:e27474
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β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
Authors: Meitzen Et al.
J Neurochem 2011;116:984
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Catecholamine up-regulates MMP-7 expression by activating AP-1 and STAT3 in gastric cancer.
Authors: Shi Et al.
Purinergic Signal 2010;9:269
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