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Prostaglandin E2

Catalog #: 2296
20 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2296/10
Prostaglandin E2 | CAS No. 363-24-6 | Prostanoid Receptor Agonists
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Description: Promotes HSCs expansion; increases HSCs engraftment; also endogenous prostaglandin
Alternative Names: PGE2

Chemical Name: (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1oic acid

Purity: ≥98%

Product Details
Citations (20)
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Biological Activity

Prostaglandin E2 is an endogenous prostaglandin and primary product of arachidonic acid/cyclooxygenase pathway. Prostaglandin E2 binds with high affinity to EP1, EP2, EP3 and EP4 receptors (Kd values range between ~ 1 - 10 nM). Prostaglandin E2 influences a wide range of processes including inflammation, vasodilation, smooth muscle relaxation, fertility, gastric mucosal integrity and platelet aggregation. Prostaglandin E2 regulates vertebrate hematopoietic stem cell (HSC) homeostasis, acts as viral transduction enhancer and is tumorigenic in some cancers.

Technical Data

M.Wt:
352.47
Formula:
C20H32O5
Solubility:
Soluble to 100 mM in DMSO and to 45 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
363-24-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.
    Coleman et al.
    Pharmacol.Rev., 1994;46:205
  2. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis.
    North et al.
    Nature., 2007;447:1007
  3. Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation.
    Hata and Breyer
    Pharm.Ther., 2004;103:147
  4. Identification of multipotent luminal progenitor cells in human prostate organoid cultures.
    Karthaus et al.
    Cell, 2014;159:163
  5. SnapShot: Growing Organoids from Stem Cells.
    Sato et al.
    Cell, 2015;161:1700
  6. Prostaglandin E2 increases lentiviral vector transduction efficiency of adult human hematopoietic stem and progenitor cells.
    Heffner et al.
    Mol.Ther, 2018;26:320

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Citations for Prostaglandin E2

The citations listed below are publications that use Tocris products. Selected citations for Prostaglandin E2 include:

20 Citations: Showing 1 - 10

  1. Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation.
    Authors: He Et al.
    Cell Stem Cell  2022;29:1333
  2. Snake venom gland organoids.
    Authors: Post Et al.
    Cell  2020;180:233
  3. IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer.
    Authors: Colomer Et al.
    Mol Cell  2019;75:669
  4. A Novel Three-Dimensional Immune Oncology Model for High-Throughput Testing of Tumoricidal Activity.
    Authors: Sherman Et al.
    Front Immunol  2018;9:857
  5. Prostaglandin receptor EP3 regulates cell proliferation and migration with impact on survival of endometrial cancer patients.
    Authors: Zhu
    Oncotarget  2018;9(1):982
  6. Directed Differentiation of Human Induced Pluripotent Stem Cells into Dendritic Cells Displaying Tolerogenic Properties and Resembling the CD141+ Subset.
    Authors: Sachamitr Et al.
    Front Immunol  2018;8:1935
  7. Prostaglandin E2 receptor 3 signaling is induced in placentas with unexplained recurrent pregnancy losses.
    Authors: Ye Et al.
    Endocr Connect  2018;7:749
  8. Human Fetal-Derived Enterospheres Provide Insights on Intestinal Development and a Novel Model to Study Necrotizing Enterocolitis (NEC).
    Authors: Senger Et al.
    Cell Mol Gastroenterol Hepatol  2018;5:549
  9. TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma.
    Authors: Somerville Et al.
    Cell Rep  2018;25:1741
  10. Prostaglandin E2-mediated adenosinergic effects on CD14+ cells: Self-amplifying immunosuppression in cancer.
    Authors: Al-Taei Et al.
    Oncoimmunology  2017;6:e1268308

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