PSB CB5
Chemical Name: (2Z)-2[[3-[(4-Chlorophenyl)methoxy]phenyl]methylene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3(2H)-one
Purity: ≥98%
Biological Activity
PSB CB5 is a selective GPR18 antagonist (IC50 = 0.279 μM). Exhibits >36-fold selectivity versus CB1 and GPR55 and 14-fold selectivity versus CB2 receptors. Inhibits N-Arachidonylglycine (Cat. No. 1445) induced acrosomal exocytosis in human spermatozoa.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55.
Rempel et al.
Med.Chem.Comm., 2014;5:632 -
Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18.
Flegel et al.
Sci.Rep., 2016;6:32255
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Citation for PSB CB5
The citations listed below are publications that use Tocris products. Selected citations for PSB CB5 include:
1 Citation: Showing 1 - 1
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N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+T cell responsiveness.
Authors: Michael N Et al.
iScience 2023;26:106578
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