(R)-(+)-Bay K 8644

Biological Activity

(R)-(+)-Bay K 8644 is a L-type Ca²⁺-channel blocker with negative inotropic and vasodilatatory effects in vivo. Enantiomer showing opposite effects to the racemate (±)-Bay K 8644 (Cat. No. 1544) and (S)-(-)- enantiomer (Cat. No. 1546). Also TMEM176B inhibitor. Induces IL-1β secretion and caspase-1 activation in bone marrow-derived dendritic cells in vitro and increases survival of tumor-bearing mice, both alone and in combination with immune checkpoint blockers.

Racemate and (S)-(-)-Enantiomer also available.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds.
   Shi et al.
   Cell Stem Cell., 2008;3:568
2. The optical isomers of the 1,4-dihydropyridine BAY K 8644 show opposite effects on Ca channels.
   Franckowiak et al.
   Eur.J.Pharmacol., 1985;114:223
3. Enantiomer selectivity and the development of tolerance to the behavioral effects of the calcium channel activator BAY K 8644.
   O'Neill and Bolger
   Brain Res.Bull., 1988;21:865
4. Opposite cardiac actions of the enantiomers of Bay K 8644 at different membrane potentials in guinea-pig papillary muscles.
   Ravens and Schopper
   Naunyn Schmiedebergs Arch.Pharmacol., 1990;341:232
5. Targeting TMEM176B enhances antitumor immunity and augments the efficacy of immune checkpoint blockers by unleashing inflammasome activation.
   Segovia et al.
   Cancer Cell., 2019;35:767

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