(R)-(-)-Phenylephrine hydrochloride
Chemical Name: (R)-(-)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride
Purity: ≥99%
Biological Activity
(R)-(-)-Phenylephrine hydrochloride is a α1-adrenoceptor agonist; pKi values are 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Selectivity of agonists for cloned α1-adrenergic receptor subtypes.
Minneman et al.
Mol.Pharmacol., 1994;46:929 -
Pharmacological pleiotropism of the human recombinant α1A-adrenoceptor: implications for α1-adrenoceptor classification.
Ford et al.
Br.J.Pharmacol., 1997;121:1127 -
α1A-adrenoceptors mediate contractions to phenylephrine in rabbit penile arteries.
Morton et al.
Br.J.Pharmacol., 2007;150:112
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Citations for (R)-(-)-Phenylephrine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for (R)-(-)-Phenylephrine hydrochloride include:
4 Citations: Showing 1 - 4
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Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.
Authors: Chai Et al.
Neuron 2017;95:531
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Selumetinib, an Oral Anti-Neoplastic Drug, May Attenuate Cardiac Hypertrophy via Targeting the ERK Pathway.
Authors: Li Et al.
PLoS One 2016;11:e0159079
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Sodium salicylate suppresses GABAergic inhibitory activity in neurons of rodent dorsal raphe nucleus.
Authors: Jin Et al.
J Neurosci 2015;10:e0126956
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Leptin does not directly affect CNS serotonin neurons to influence appetite.
Authors: Lam Et al.
PLoS One 2011;13:584
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